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Showing 1 to 20 of 138 for “"Toxoplasma Gondii"”.
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RNAi-related genes in Toxoplasma gondii.
… specific gene silencing is functional in Toxoplasma gondii, an intracellular parasite of humans and other mammals. In the present study, we describe the characterization of the first Argonaute protein (TgAgo) in T. gondii. The cDNA clone has an open reading frame (ORF) of 1575 bp which …
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Immunological control of toxoplasma gondii infection
Prevalent worldwide, the protozoan parasite, Toxoplasma gondii, is an important cause of spontaneous abortion, ocular disease, mental retardation and encephalitis. Currently there are no human vaccines available. The first major aim of this study was to test potential HLA restricted peptide …
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Rodent inflammasome activation by Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular pathogen capable of chronically infecting nearly all warm-blooded animals, including humans. The chronic stage is characterized by the presence of semi-dormant cysts in brain and muscle tissues. These cysts are crucial in the success of Toxoplasma as …
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Funktionelle Charakterisierung antioxidativer Enzyme aus Toxoplasma gondii
… zu dem der obligat intrazelluläre Parasit Toxoplasma gondii gehört, waren bis zum Beginn dieser Doktorarbeit noch keine Peroxisomen beschrieben, ein in fast allen eukaryontischen Zellen vorkommendes Organell. Das Markerprotein von Peroxisomen ist das Enzym Katalase, welches …
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Kompartementalisierung des Kohlenhydrat-Stoffwechsels in Toxoplasma gondii
Toxoplasma gondii ist ein obligat intrazellulärer Parasit der nahezu jede eukaryotische, kernhaltige Zelle invadieren und in ihr replizieren kann. Im Zwischenwirt kommt T. gondii in zwei unterschiedlichen Stadien vor, während der akuten Infektion als schnell replizierender Tachyzoite sowie nach dem …
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Sphingolipids in Toxoplasma gondii; synthesis and scavenging
Toxoplasma gondii is a globally endemic parasite which can cause severe illness in animal livestock and humans. Currently there are no effective drug treatments which do not have severe side effects and therefore the search for new drugs is of significant importance. Sphingolipids have been shown …
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Multidimensional profiling of the Toxoplasma gondii proteome
… malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii), making the understanding of these parasite signaling pathways of global importance. Although components of secondary messenger signaling pathways are conserved among apicomplexans and higher eukaryotes, 800 million years of …
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Sphingolipid synthases of Toxoplasma gondii and other organisms
Toxoplasma gondii is an obligate intracellular protozoan parasite of the phylum Apicomplexa, and toxoplasmosis is an important disease in immuno-compromised individuals - especially AIDS patients, organ transplant recipients and patients receiving anti-cancer chemotherapy. Toxoplasmosis also has …
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Development and characterization of novel toxoplasma gondii inhibitors
Toxoplasma gondii</italic> is an obligate intracellular, protozoan parasite of the phylum Apicomplexa. While the parasite relies on the feline to complete its life-cycle, many mammals can contract the infection. In humans, infection can cause serious illness or death. Treatments currently available …
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Genetic diversity of African isolates of Toxoplasma gondii
Toxoplasma gondii is an intracellular protozoan parasite and has the ability to infect allwarm-blooded animals, including humans. While the three clonal lineages of T. gondii (I, IIand III) predominate in North America and Europe, strains from other regions in the worldappear to have more diverse …
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
… the obligate intracellular protozoan parasite Toxoplasma gondii, a ubiquitous pathogen of humans and other vertebrates. We produced and sequenced 24 strand-specific RNA libraries from several parasite strains and developmental stages, and examined these in conjunction with 45 additional …
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Utilizing Toxoplasma gondii To Understand Neuron-Specific Neuroinflammation
Toxoplasma gondii infects up to one third of the world’s population. The parasite can persist for the life of the host by hiding in neurons in the Central Nervous System (CNS). It was thought that neurons permitted this chronic infection due to a lack of innate immune capabilities including …
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Investigations Into the Function of Elp3 in Toxoplasma Gondii
The parasite Toxoplasma gondii causes life-threatening infection in immunocompromised individuals. Our lab has determined that Toxoplasma Elongator protein-3 (TgElp3) is required for parasite viability. While catalytic domains are conserved, TgElp3 is the only component of the six-subunit Elongator …
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Production of Monoclonal Antibodies for Toxoplasma gondii Lactate Dehydrogenase
"Background/Purpose: Toxoplasma gondii is one of the most common parasitic infections of human and other warm blooded animals. Because of the geographical distribution of toxoplasmosis, there is a need to develop a sensitive, rapid, simple and an inexpensive test for the early screening of patiens. …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… long-term infection. The apicomplexan parasite, Toxoplasma gondii, is one such pathogen with the ability to infect the CNS in virtually all warm-blooded animals, including humans. Across the globe, an estimated 30% of the human population is infected with Toxoplasma, an infection for which …
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Mechanisms underlying Toxoplasma gondii-mediated behavioral changes of its host
Toxoplasma gondii is a parasite that can infiltrate different hosts and alter behavior. It can create an attraction to cat urine in rats or influence a culture. Different mechanisms have been proposed in the pursuit of understanding the control T. gondii has on its host, including the modulation of …
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Charakterisierung und Lokalisation der Toxoplasma gondii Katalase: Peroxisomen in Apicomplexa?
Toxoplasma gondii ist ein obligat intrazellulärer, einzelliger Parasit aus dem Phylum der Apicomplexa. Infektionen des Menschen mit T. gondii verlaufen meist subklinisch. Nach einer Infektion persistiert der Erreger für viele Jahre in Hirn- und Muskelgewebe. Durch Reaktivierung des Erregers, z. B. …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
Toxoplasma gondii ist ein obligat intrazellulärer Parasit des Phylums Apikomplexa, der durch sein breites Wirtsspektrum und die lebenslange Persistenz in seinem Wirt zu einem der erfolgreichsten Parasiten gehört. Eine Infektion verläuft bei immunkompetenten Personen meist symptomlos, bei Föten oder …
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Deciphering host-parasite molecular networks mediating resistance to toxoplasma gondii
Toxoplasma gondii (T. gondii) is an obligate intracellular apicomplexan protozoan parasite that infects about one-third of the world population, with estimated medical costs and loss of productivity in the USA alone amounting to about US$3.1 billion annually. Additionally, in the USA, T. gondii is …
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