Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Toxicogenomics"”.
-
Toxicogenomics of Apis Mellifera
Collectively, the studies reported in this dissertation demonstrate that honey bee P450s associated with detoxification are few in number, that these P450s appear to have evolved to respond specifically to natural compounds encountered in the hive environment, and that honey bees have a limited …
-
Probabilistic Graphical Modeling on Big Data
… to modern statistical analysis and modeling. In toxicogenomics, the advancement of high-throughput screening technologies facilitates the generation of massive amount of biological data, a big data phenomena in biomedical science. Yet, researchers still heavily rely on key word search and/or …
-
Discovery of multi-omics biomarkers for toxicity using meta-analysis
… preparation & class assignment 23 1. Building of toxicogenomics database using gene expression from integrated studies 23 2. Toxicity class assignments 24 3. Correlations and levels of compound toxicity in multiple organs 26 4. Distribution of sample toxicity levels across compounds 28 B. …
-
Understanding compound-induced histopathology in rat liver using gene expression network methods
… biology, and so falls within the field of toxicogenomics. As such, the databases in the public domain are crucial to progress. DrugMatrix and Open TG-GATEs were identified as containing large, in vivo transcriptomics data with histopathological observations as endpoints, a proxy for …
-
Regulation of cytochrome P450 genes in drosophila melanogaster by the chemical environment
Cytochrome P450 monooxygenases (P450s) play an important role in the adaptive response of insects and other animals to chemicals in the environment. P450s are heme-dependent enzymes that catalyze the addition of oxygen to a substrate in the presence of an electron donor, such as NADPH. In insects, …
-
Development of advanced methods for large-scale transcriptomic profiling and application to screening of metabolism disrupting compounds
High-throughput transcriptomic profiling has become a ubiquitous tool to assay an organism transcriptome and to characterize gene expression patterns in different cellular states or disease conditions, as well as in response to molecular and pharmacologic perturbations. Refinements to data …
-
Mechanisms of monohalogenated acetic acid induced genomic DNA damage
Disinfection of drinking water stands among the greatest public health achievements in human history. Killing or inactivation of pathogenic microbes by chemical oxidants such as chlorine, chloramine, or ozone have greatly reduced incidence of waterborne diseases. However, the disinfectant also …
-
Using transcriptomic data to detect, understand, and treat injury in the context of drug toxicity and fibrotic disease
In drug discovery, it is crucial to understand how drugs relate to complex phenotypes. This includes understanding how a drug can help to treat a condition, but also how it can result in adverse effects so that safety risks can be mitigated earlier. How effects propagate from the molecular to the …