Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Toxicity screening"”.
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DEVELOPMENT OF MICROBIAL ELECTROCHEMICAL SENSOR FOR TOXICITY SCREENING OF INFLUENT WASTEWATER
… that is capable to detect influent wastewater toxicity was presented, having the characteristics of being quick, preventative, simple, inexpensive, on-line, and relevant to the activated sludge process. The MES was firstly optimized in terms of both sensing material (biofilm) and the transistor …
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IMPLEMENTATION OF 3D CELLULAR MODELS FOR DRUG AND TOXIN TESTING IN HEALTHY AND CANCEROUS TISSUE
… these shortcomings in the form of a potential screening tool, we employed bioengineered 3D liv er and cardiac organoids biofabricated from multiple physiologically relevant human cell groups to represent healthy tissue , and tumor organoids derived from colorectal cancer cells from established …
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Development of a rapid Hormosira banksii bioassay using chlorophyll a fluorescence
… macroalgal communities, and as an effective toxicity screening tool.
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Systems Engineering of Stem Cell Fate
… in vitro models for liver diseases and drug toxicity screening. A differentiation protocol mimicking key signaling cues of embryonic development was developed to direct stem cells (ES) towards the hepatic fate and express key hepatic markers and functions. While these results are encouraging, …
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Engineered microtissue platforms for modeling human pathophysiology and drug metabolism
… testing. Liver metabolites that cause toxicity or other side effects cannot always be predicted in animals, in part because of human-specific drug metabolism. Furthermore, while the clinical need for cancer drugs is increasing, anti-tumor activity in animals often leads to a …
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Prädiktive Wertigkeit dreier onkogeriatrischer Screenings
… patients are vulnerable to chemotherapy-related toxicity (CRT). Therefore we evaluated screening tools in their power to predict CRT. Methods: Patients with cancer aged ≥65 years completed three screening questionnaires (G8, optimised G8 and Cancer and Ageing Research Group (CARG). Additionally, …
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An informatics approach to prioritizing risk assessment for chemicals and chemical combinations based on near-field exposure from consumer products
… only a few hundred have been screened for human toxicity. Not even those used in everyday consumer products, and known to have widespread exposure in the general population, have been screened. Toxicity screening is time-consuming, expensive, and complex because simultaneous or sequential …
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Responses of an Environmental Gram-negative Bacterium to Pollutant Stress
… providing a potentially sensitive tool for toxicity screening for terrestrial and fresh water samples. To show the use of bioluminescence in the indigenous (naturally non-bioluminescent) organism, research was performed on stable marking and optimisation of light output including marking of …
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Discovery of small-molecule natural products that target cellular bioenergetics
… the development of a bioenergetics-based screening method to screen crude extracts for glycolysis inhibitors. Crude extracts (10,648) were screened and seven hits (hit rate 0.72%) were identified. Bioassay-guided isolation of Moronobea coccinea crude extract resulted in isolation of a …