Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Toxicity data"”.
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Analysis of Virtual Control Groups and Inter-species Concordance using Preclinical Toxicity Data
… 1 (Introduction). In line with the US EPA’s “Toxicity Testing in the 21st Century: A Vision and Strategy” and the Replacement, Refinement, and Reduction (3Rs) goals for animals in toxicity testing, the current two species preclinical testing paradigm for small molecules outlined in ICH M3 (R2) …
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Integration of Toxicity Data from Experiments and Non-Testing Methods within a Weight of Evidence Procedure
… a conclusion. There is an increasing need for data to fill the gaps and new methods for the data integration. From a regulatory point of view, risk assessors take advantage of all the available data by means of weight of evidence (WOE) and expert judgement approaches to develop conclusions …
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Comparative Toxicity of Eight Model Substances to the Sediment Dwelling Invertebrates Lumbriculus variegatus and Chironomus riparius
Existing ecotoxicity data for chemicals vary to a high extent between the environmental compartments water and sediment, since the evaluation of contaminants has historically focused on water exposition. Many anthropogenic chemicals and waste materials, including toxic organic and inorganic …
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Identifying Context-Specific Synthetic Lethal miRNA Inhibition in Non-Small Cell Lung Cancer
… to identify miRNA inhibitors with selective toxicity in the NSCLC cell lines that were also benign in an HBEC cell line. Two inhibitors, the miR-92a and miR-1226* inhibitors, met these criteria. I then collected toxicity data in an expanded panel of 29 total cell lines. This expanded toxicity …
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Improving the risk assessment of short-term stormwater and effluent discharges to aquatic environments
… in short-term exposures of organisms. Current ecotoxicity methods may be unsuitable to assess the risk of short-term contaminant exposures. This is because there is evidence to suggest that aquatic organisms can tolerate higher concentrations of some contaminants when exposed for a shorter …
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Evaluation of the environmental viability of direct injection schemes for ocean carbon sequestration
… earlier studies, incorporates recent acute CO2 toxicity data on marine organisms, and considers three revised discharge approaches: a point release of negatively buoyant CO2 hydrate particles from a moving ship; a long, bottom-mounted diffuser discharging buoyant liquid CO2 droplets; and a …
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Utilization of mitochondrial and microsomal metabolism for the assessment of toxicity
Short-term toxicity tests utilizing mitochondrial and microsomal metabolism were developed and applied to a series of eight quinones. In the mitochondrial assay, the degree to which test compounds inhibited mitochondrial respiration varied from an EC50 of 9 μM to l25 μM. In the microsomal assay, …
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The toxicity of ammonia to the marine organisms, sheepshead minnow (Cyprinodon variegatus), mysid (Mysidopsis bahia), and grass shrimp (Palaemonetes pugio)
… calculated using both freshwater and saltwater toxicity data. Therefore, additional bioassays needed to be performed with marine organisms in order to refine this limit based solely on saltwater organisms. Acute bioassays were conducted with one marine fish, the sheepshead minnow (Cyprinodon …
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Quantifying the U.S. Coast Guard Ecological Risk Assessment on Diluted Bitumen
… (CERA) on diluted bitumen (DB) and compare the toxicity of DB to conventional crude (CC) oils. At the height of the domestic energy renaissance, 103,000 barrels of DB were transported via railcar each day to five refineries throughout the Delaware Bay tri-state region. To assess the emerging …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific discussion on all aspects of drug formulation and …
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A Knowledge Based Approach of Toxicity Prediction for Drug Formulation. Modelling Drug Vehicle Relationships Using Soft Computing Techniques
… of drug formulations for the reduction of drug toxicity. Both scientific and computational approaches are utilised to make original contributions to the field of predictive toxicology. The first part of this thesis provides a detailed scientific discussion on all aspects of drug formulation and …
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Toxic Effects of an Anionic Detergent on the Gills of Trout
The literature on the toxicity of synthetic detergents to fish and aquatic invertebrates is reviewed. The pathological effects of an anionic detergent, sodium lauryl sulphate, on the gills of rainbow trout have been studied by light and electron microscopy. At lethal concentrations up to about 120 …
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Toward improved in vitro models for human health risk assessment : mechanisms of short-chain per- and polyfluoroalkyl substances (PFAS) toxicity.
… these alternatives still lack sufficient toxicity data, emphasizing the need for robust chemical safety assessments. Initiatives to develop rapid and cost-effective solutions that utilize exposure-based strategies, hypothesis-driven tiered systems, and animal-free toxicological testing …
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In Silico Classification of Industrial Chemicals Associated with Acute Aquatic Toxic Action Utilising Molecular Initiating Events
… as an important part of understanding toxicity to aquatic organisms. However, current MOA classification approaches for acute aquatic toxicity endpoints are limited by their chemical and mechanistic domains. This thesis developed an in silico classification scheme for aquatic toxicology …
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Integration of Data Quality, Kinetics and Mechanistic Modelling into Toxicological Assessment of Cosmetic Ingredients
… to potential pharmaceuticals only, most toxicity data relevant for regulatory decision-making are based on in vivo data. Due to the ban on animal testing of cosmetic ingredients in the European Union, alternative approaches, such as in vitro and in silico tests, have become more …
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River Sediment Sampling and Environment Quality Standards: A Case Study of the Ravensbourne River
… standards. This is partly due to insufficient toxicity data but also due to problems with identification of appropriate sediment monitoring and analytical techniques. The aim of this research was to examine the sampling different river sediment compartments in order to monitor compliance with …
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The Toxicity of Ammonia to Atlantic Silverside (Menidia menidia) and Ghost Shrimp (Palaemonetes pugio)
… to protect aquatic organisms from the toxicity of ammonia. Discharge into Chesapeake Bay has not yet been regulated under this criteria. Ammonia limits of 1-2 mg/L total ammonia have been proposed for the marine waters in Virginia based on the national criteria of 0.035 mg/L of …
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Ecotoxicological Risk Assessment: Developments in PNEC Estimation
… summary statistic of observed laboratory derived toxicity data, or as a percentile of a distribution over the ecological community sensitivity. Often it is the situation that a hazard assessment will be based on substantially small samples of data. In this thesis we evaluate proposals for …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation.
… endpoints for a wide range of chemicals. Data plays an important role in modelling QSARs and also in result analysis for toxicity testing processes. This research addresses number of issues in predictive toxicology. One issue is the problem of data quality. Although large amount of …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation
… endpoints for a wide range of chemicals. Data plays an important role in modelling QSARs and also in result analysis for toxicity testing processes. This research addresses number of issues in predictive toxicology. One issue is the problem of data quality. Although large amount of …
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