Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Toxicity assessment"”.
-
Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… sensitive and high throughput astrocyte toxicity assay that is more relevant to the human response than existing animal cell based models, the U251-MG, U373-MG and CCF-STTG 1 human astrocytoma cell lines were investigated for their ability to exhibit reactive-like changes following …
-
Toxicity assessment of pesticides and biopesticides on wild and managed bees (Hymenoptera, Apoidea), and richness evaluation in mediterranean and tropical agroecosystems
… During this PhD project, we studied the toxicity of synthetic pesticides and biopesticides on wild and managed bees, using different products marketed in Mediterranean and tropical areas, and some nanoformulations of essential oils (EOs) tested on pests but not yet commercialized. Lethal …
-
Assessing toxicity of carbon based nanoparticles in cells and zebrafish by using biospectroscopy
… post-exposure biochemical alterations in toxicity assessment due to the induced changes of chemical composition and structure reflected by their spectral properties. Over the past few decades, Raman and IR spectroscopies with the development of more sophisticated instruments can provide …
-
AMPHOTERIC POLYAMIDOAMINES AS FUNCTIONAL SPECIALTY POLYMERS
… during or after their useful life. The ecotoxicity of PAAs was evaluated on the early stages of plant development using Lepidium sativum (watercress) seeds. In this study, the effectiveness and robustness of the seed germination test for assessing the phytotoxicity of water-soluble polymers …
-
UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
… shifting efforts toward alternative methods for toxicity assessment is essential. However, slow regulatory acceptance of new approaches is governed by knowledge gaps in toxicity modes of action. In this thesis, I describe these challenges and the use of in vitro screening as an alternative of …
-
Environmental Risks, the Leverage of Scientific Information and Data, and Mediated Communication
… Environmental Protection Agency (US EPA)'s Draft Toxicity Assessment for GenX, one of the PFAS chemicals, on news topics. Results indicate that the influence of new risk knowledge on news topics varies depending on community context, with significant impacts observed when communities are ready for …
-
Group IV element-based luminescent nanoparticles: synthesis, environmental impact evaluation and bio-imaging applications
… polymeric carbon dots as well as the bacterial toxicity assessment of CDs as well as Si and Ge nanocrystals using an environment-related bacterium, Shewanella oneidensis MR-1. Specifically, Chapter 1 summarizes recent progress in the syntheses and applications of multicolor CDs. Chapter 2 …
-
Bench-scale fire toxicity measurements of polymers and cables
… techniques and their limitations for fire toxicity assessment including closed box test (NBS Smoke Density Chamber) and flow-through tests such as the steady state tube furnace (ISO TS 19700). Toxicity results for several different polymers under different fire scenarios have been compared …
-
Analysis of Virtual Control Groups and Inter-species Concordance using Preclinical Toxicity Data
… 1 (Introduction). In line with the US EPA’s “Toxicity Testing in the 21st Century: A Vision and Strategy” and the Replacement, Refinement, and Reduction (3Rs) goals for animals in toxicity testing, the current two species preclinical testing paradigm for small molecules outlined in ICH M3 (R2) …
-
Microfluidic Devices for Neural and Behavioral Screening of C.Elegans using Electric Field
… disease pathology to screening for chemicals toxicity and therapeutic effects. However, technological deficiencies in achieving automated, fast, simple, and low-cost C. elegans-based screening assays have hindered the widespread use of this organism in the gene screening, toxicology and …
-
The destruction of the cyanobacterial toxin microcystin-LR by semiconductor photocatalysis.
… determined the fate of the compound, or if the toxicity related to microcystin-LR has been removed. This study was carried out to determine if photocatalytic oxidation of microcystin-LR was suitable as a treatment method for potable water supplies. Analysis of treated toxin samples by high …
-
Development of a holistic risk assessment methodology and a corresponding computer model for landfill leachate
… reports on the development of a holistic risk assessment methodology and a corresponding computer model for landfill leachate. Lack of a quantitative risk assessment methodology in a holistic format has prompted this research.<br/><br/>The two main aims of the study are:<br/><br/>• To …
-
Leveraging cell micropatterning technology for rapid cell-based assessment of chemical toxicity and population variation in toxicity susceptibility
… presents a unique and costly challenge to toxicity testing in the 21 st century. In recent years, the United States has seen large coordinated efforts across governmental agencies to shift from expensive and slow traditional in vivo tests to more affordable and higher throughput in vitro …
-
Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds
… of A549 cells (Chapter 4). Initially, the cell toxicity has been assessed in order to ensure that most of the concentrations used in the following proteomic approach were not cytotoxic. Significant changes in abundance and phosphorylation in the total soluble protein fraction of A549 cells have …
-
Surface functionalized iron oxide nanoparticles for applications in biomedical sciences
… imaging quality and thus provide more detail for assessment. However, previous studies using nanoparticles for MR and CT were prepared with surface coating stabilizers, which in turn can compromise the use in clinical studies. In this chapter, gold-iron oxide nanoparticles (Au*MNP) are presented …
-
THE SHORT- AND LONG- TERM EFFECT OF ZINC AND COPPER CONTAMINATION ON SOIL MICROBIAL FUNCTIONS
… to then assess contaminated sites and determine toxicity. This experiment aimed to reduce the overall quantity of soil required by an order of magnitude. The assessment of soil nutrient cycling forms a part of all site investigations carried out by Canadian risk assessors. One of the key factors …
-
Synthesis and potential application of Fe3+/Mn2+ bimetal and hexadecyltrimethylammonium bromide (HDTMA-Br) modified clayey soils for arsenic removal in groundwater
… to establish the population at risk, 3) The toxicity assessment for HDTMA-Br modified kaolin clay should be carried out, 4) Materials developed in the present study should be modeled and tested at the point of use for arsenic removal, and lastly, 5) this study further encourage the …
-
Responses of an Environmental Gram-negative Bacterium to Pollutant Stress
… providing a potentially sensitive tool for toxicity screening for terrestrial and fresh water samples. To show the use of bioluminescence in the indigenous (naturally non-bioluminescent) organism, research was performed on stable marking and optimisation of light output including marking of …