Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Toxicant exposure"”.
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity. </p> <p>Previous studies suggested that …
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… to exhibit reactive-like changes following exposure to ethanol, chloroquine diphosphate, trimethyltin chloride and acrylamide. Cytotoxicity analysis showed that the astrocytic cells were generally more resistant to the cytotoxic effects of the agents than the SH-SY5Y neuroblastoma cells. …
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Delivery of Smoke Toxicants from Cigarettes Made in Developed and Developing Countries: a comparison of U.S. full flavor and ultra light brands with Syrian cigarettes
… research is needed to understand how cigarette toxicant yield affects smoker toxicant exposure. While there is much clinical research on yield and exposure in developed countries, there is little in developing countries. Forty smokers completed one, 4-hour session to compare yield and exposure …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… from internal metabolism and environmental toxicant exposure, which have been linked to the initiation and progression of many neuronal diseases such as Alzheimer’s and Parkinson’s diseases. Exposure to reactive oxygen species are counterbalanced by antioxidant defense systems such as the …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… from internal metabolism and environmental toxicant exposure, which have been linked to the initiation and progression of many neuronal diseases such as Alzheimer’s and Parkinson’s diseases. Exposure to reactive oxygen species are counterbalanced by antioxidant defense systems such as the …
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Novel approaches to toxicity testing in Daphnia magna
… to use this approach to discriminate between toxicant modes of action (MOA) and to link toxicant induced metabolic effects to reduced reproductive output in D. magna. FT-ICR MS metabolomics was determined to be a feasible approach for toxicity testing of both whole-organism homogenates and …
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Circulating sex hormone levels in rats: a systematic analysis of the literature and perinatal BPA study
… role in elucidating the mechanisms by which a toxicant exerts its deleterious effects, as well as serving as a translational system for comparison to human biology. The anatomy, physiology, and molecular mechanisms of the reproductive system of these models should first be well characterized …
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Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… (HBM) is an ideal tool for evaluating toxicant exposure in health risk assessment. Chemical substances or their metabolites related to environmental pollutants can be detected as biomarkers of exposure using a wide variety of biological fluids. Individual exposure to aromatic …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
In utero exposure to benzene, a known environmental contaminant, is associated with increased risk of childhood leukemia. We have previously shown that in utero benzene exposure can alter the redox sensitive transcription factor NF-κB, which is up-regulated in leukemia. We hypothesize that this is …
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The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
… lung disease by environmental tobacco exposure are unclear. Therefore, we investigated the effect of co-exposure of airway epithelial cells to cigarette smoke condensate (CSC) and RSV on inflammatory chemokine gene expression. We demonstrated that CSC and RSV synergistically increased …
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Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
… context of AD. We hypothesized that postnatal toxicant exposure in a mouse model of AD (Tg) would disrupt neuroimmune development preferentially in females, in parallel with human AD sex bias, incurring altered regulation of microglial response phenotypes early in life that then functionally …
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Applying a Systems Approach to the Legacy of Lead in Soil
… soil and continue calling for efforts to limit toxicant exposure. Why, then, does this issue persist? What can be done about it? What role can biogeochemical research play in not only describing the issue, but also in conducting experiments and gathering data on alternative life-affirming …
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A multidisciplinary study of the Asiatic clam, Corbicula fluminea, from the New River, Virginia
… to brief (24 hr) and extended (30 d) periods of exposure to toxicants were investigated. These studies addressed the valve closure behavioral response by adults exposed to chlorine, cadmium, and zinc; the effects of these pollutants and temperature on the levels of metal binding protein in …
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A role for environmental epigenetics in the rapid diversification of East African cichlid fishes
… inputs, including nutrition, temperature, and toxicant exposure. However, studies in environmental epigenetics have focused primarily on DNA methylation, leaving the role of other epigenetic mechanisms largely unexplored. This is particularly true regarding vertebrate models. Moreover, very few …
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Investigating mechanisms of ovotoxicity of Perfluorooctanoic acid and Zearalenone exposure and the influence of altered metabolic status on ovarian function
Exposure to xenobiotics termed ovotoxicants can alter the quality and maintenance of oocytes and synthesis and secretion of hormones, which are the major roles of the ovary, leading to premature ovarian failure and infertility. Obesity has several negative reproductive effects in women, and in …
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The transgenerational effects of Di(2-ethylhexyl) phthalate on female reproduction in mice
… blood, breast milk, and human follicular fluid. Exposure to DEHP is a public health concern because DEHP is a known endocrine disrupting chemical and reproductive toxicant in females. The presence of DEHP in tissues vital for reproduction and development suggests that DEHP exposure occurs at …