Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 221 for “"Toxic effects"”.
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Toxic Effects of an Anionic Detergent on the Gills of Trout
The literature on the toxicity of synthetic detergents to fish and aquatic invertebrates is reviewed. The pathological effects of an anionic detergent, sodium lauryl sulphate, on the gills of rainbow trout have been studied by light and electron microscopy. At lethal concentrations up to about 120 …
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Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells
… the IFNp (interferon-beta) level and cellular toxicity of ssRNAs in SKOV3 cells. In this work, we confirmed that 5'-ppp-ssRNA (~ 60nt) was immunostimulatory and toxic in SKOV3 cells. 5'-ppp-ssRNA (~ 60nt) led to IFN-P induction and apoptosis in SKOV3 cells. Longer 5' ppp- ssRNA tended to have a …
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Disposition and Toxic Effects of Polychlorinated Biphenyls Following Different Routes of Exposure
The differences in disposition and toxic effects of PCBs caused by different exposure routes were demonstrated. Therefore, to better estimate human health effects following exposure to PCBs, it is crucial to identify PCB congener profiles in the exposure sources.
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Evaluation of the potential environmental toxic effects of a nylon fibers additive
… required by law to be evaluated for potential toxic effects upon disposal to the environment. A thorough evaluation, however, is complex, time-consuming, expensive, and impossible to perform on each new substance. In this study the potential toxic effects of a new carpet additive with …
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Toxic effects on model mammalian cells by monohalogenated disinfection byproducts: haloacetic acids and haloacetonitriles
… DBPs have been found to be mutagenic, cytotoxic, genotoxic, carcinogenic, teratogenic and developmentally toxic, the precise mechanisms of toxic action by DBPs is largely unknown. With the recent findings of toxicity pattern associated with halogen and nitrogenous functional groups, …
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Toxic effects of aromatic hydrocarbon mixtures isolated from crude oils to blue mussels (Mytilus edulis)
This thesis studies the narcotic toxicity of complex fractions of total aromatic and monoaromatic hydrocarbons isolated from four different crude oils. The blue mussel (Mytilus edulis) biotest used shows a reduction of mussel feeding activity after 24 h exposure with increasing aqueous and tissue …
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The toxic effects of the pesticide lindane on the early developmental stages of the fathead minnow
Toxic effects of the pesticide Lindane on the eggs, yolksac fry and larvae of the fathead minnow (Pimephales promelas) were investigated over 14 days at 25 and 18°C. The general objective was to understand the effects of the pesticide on the early life stages of the fish, and to evaluate the …
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Toxic effects of dietary methylmercury on immune system structure, function, and development in the American kestrel (Falco sparverius)
… three investigations in which immunosuppressive effects of environmentally relevant concentrations of dietary methylmercury (MeHg) were assessed in adult non-breeding male kestrels, female kestrels during egg laying, and nestling kestrels. Immunological endpoints included cell-mediated immunity …
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Studies of the excretion of aluminium by the kidney and the toxic effects of the element on DNA
… has been shown to be the cause of considerable toxicity, particularly in the setting of chronic renal failure. Diseases that have been shown to be associated with aluminium, or in which it has been implicated, include dialysis dementia, renal osteodystrophy and Alzheimer's disease. This thesis …
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Evaluation of the toxic effects of eltenac (4-((2,6-dichlorophenyl) amino)-3-thiophene acetic acid), a nonsteroidal anti-inflammatory drug, in horses
… study was performed to determine the potential toxic effects of the new nonsteroidal anti-inflammatory drug, eltenac (4-[(2,6-dichlorophenyl) amino]-3-thiopheneacetic acid), in horses. Four treatment groups were formed, each composed of 6 horses. The drug was injected intravenously, once daily, …
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Examination of Direct and Indirect Effects of Legacy Industrial Pollution On Organ Growth in Wild Yellow Perch (Perca flavescens)
… in aquatic ecosystems, I investigated the effects of chronic pollution on organ growth in fish. Specifically, I examined which organs are most sensitive to pollution and whether these changes were prompted by the indirect effects of impoverished food webs resulting from chronic pollution or …
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Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
… to lessen the dose-limiting myelosuppressive effects of several anti-cancer drugs. Its mechanism is unknown, but several possible sites of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow against the toxic effects of myelosuppressive drugs.
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Do Elevated Levels of Glutathione Decrease the Toxicity of Plasticizers in Mouse Liver Cells?
… caused public health concerns because of their toxic effects on reproductive and developmental processes. This study aims to investigate the response of two mouse hepatoma cell lines to the effects of DEHP and its bioactive metabolite mono (2-ethylhexyl) phthalate (MEHP). Cells were exposed to …
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Evaluation of modified montmorillonites in poultry diets
… protection of broiler chicks against the adverse effects of AF, and to determine if the modified MONTs would be bioavailable mineral sources. Cu-MONT ameliorated the growth depressing effects of AF, and the deleterious effects of AF on relative organ weights. Results suggest that Cu-MONT was …
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Arsenic Toxicity and Altered Mitochondrial Bioenergetics in Response to Oxidative Stress
… the mechanism by which arsenic exerts its toxic effects is crucial to developing preventative strategies and more effective treatments for individuals with long term exposure to arsenic compounds. This thesis outlines the epidemiological evidence for arsenic-linked diseases as well as the …
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Behavioral assessment of the time course and relative intensity of acute lithium chloride toxicosis in adult and weanling rats
… course of and developmental differences in the toxic effects of a single i.p. injection of LiCl. The studies examined LiCl' s effect on food reinforced bar pressing, open-field behavior, water intake, and taste aversion learning. Both experiments used a 2 x 3 x 21 mixed design which provided for …
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
Contamnant exposure has been associated with toxic effects in marine mammals. Studies on early biochemical and molecular responses prior to, but associated with, contaminant-induced toxicity will aid in understanding the susceptibility of cetaceans to such exposures. Cytochrome P450 1A1 (CYP1A1) …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… a cell model and an animal model to evaluate the effects of NACA. Our data suggest that pretreatment with NACA reduces the sub-lethal (but not lethal) effects of TBHP in primary cultures of human retinal pigment epithelial cells. NACA significantly improves cell survival when administered prior to …
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Toxicological studies of the combined effects of aluminium, copper and manganese on a freshwater amphipod in acidic waters
This thesis describes the combined toxicity in aqueous solutions of three common metals (Al, Cu and Mn) on the endemic freshwater amphipod Paramelita nigroculos (Barnard) from the south-western Cape region of South Africa. The aims of the work were three-fold: to examine the toxic effects of …
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