Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ToxCast"”.
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Developmental Malformations in Zebrafish Caused by Exposure to Environmental Pollutants
… screening of 292 unique chemicals from the ToxCast Phase I library identified 38 skeletal disruptor compounds (SDCs) producing bone and craniofacial cartilage malformations in zebrafish. We used ToxCast in vitro data and RT-qPCR to predict that these compounds affect vitamin D metabolism and …
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Development of Nontargeted Screening Algorithms for Indoor Contaminants
… the COVID-19 pandemic and screened against the ToxCast and Tox21 databases. Among 1037 ToxCast compounds, 43 were detected with high frequency plus 8 additional dyes and OPCs. Several plasticizers and disinfectants also showed an increase in concentration during periods of public lockdown …
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Structure-based Predictions for Molecular Initiating Events
… from human in vitro¬ assays in the ChEMBL and ToxCast databases. The new models significantly improve on previous models, with performance metrics comparable to random forest models. Methods for further improving structural alert models are presented, including a method for generalising …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… chemicals. Third, high throughput screening of ToxCastTM Phase I pesticides library and NIH Clinical Collection drug library was performed using Tg(5xERE:GFP) reporter fish. A total of 26 environmental estrogens and 62 clinical drugs with estrogenic activities were identified from these two …
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UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
It is estimated that 115 million animals are used in experimental testing each year. Hence, shifting efforts toward alternative methods for toxicity assessment is essential. However, slow regulatory acceptance of new approaches is governed by knowledge gaps in toxicity modes of action. In this …