Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Tousled-like Kinase"”.
-
Characterization of A Novel Role For The to usled- Like Kinase In Kinetochore Assembly and Function In Caenorhabditis Elegans
… previous work identified the<em> C. elegans </em>Tousled-like kinase (TLK-1) as a mitotic kinase and depletion of TLK-1 results in embryonic lethality, characterized by nuclei displaying poor mitotic chromosome alignment, lagging chromosome, and chromosome bridges during anaphase. Additionally, …
-
Validation of The Activation of Aurora B Kinase By Caenorhabditis Elegans to usled-Like Kinase and The Identification of Cyclin B3 As A Phospho-Specific Tlk-1 Interactor
… have confirmed that the conserved Aurora B/AIR-2 kinase is required for multiple mitotic events including the proper attachment of microtubules to kinetochores, activation of a checkpoint that monitors kinetochore-microtubule attachment, and separation of daughter cells during cytokinesis. Our …
-
Identification and Analysis of A Novel Role For The to usled-Like Kinase In Regulating Mitotic Spindle Dynamics
<p>Deregulation of kinase activity is one example of how cells become cancerous by evading evolutionary constraints. The Tousled kinase (Tsl) was initially identified in <em>Arabidopsis thaliana </em>as a developmentally important kinase. There are two mammalian orthologues of Tsl and one …