Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Totipotency"”.
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Free radical mediated oxidative stress in plant cancers
… metabolism, oxidative stress and loss of totipotency.<br/><br/><i>In vitro</i> aged callus cultures of <i>G. max</i> maintained in tissue culture for approximately fifteen years had lost their embryogenic capacity and one of the cell lines has lost the ability to produce pigments. …
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DNA methylation in early mammalian development
… dynamics of global demethylation that lead to totipotency and the subsequent changes to embryonic specification. In Chapter 1, I validate and refine the decades old model for DNA methylation in mouse embryogenesis, identify many retrotransposons with active DNA methylation signatures at …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
… mouse embryonic stem cells (mESCs) by activating totipotency and extra-embryonic pathways. However, the underlying epigenetic mechanisms remain unclear. Preliminary data indicated that polycomb repressive complex 2 (PRC2)-targeted genes are aberrantly activated upon replication stress in mESCs. …
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The role of transcription factors in somatic cell nuclear reprogramming by eggs and oocytes
… somatic cells to an embryonic state and gain totipotency (Gurdon et al., 1958). Additionally, induced pluripotency is applied to transform identities of somatic cells to induced pluripotent stem cells by overexpression of combinatorial Yamanaka factors (iPS, Takahashi et al., 2006). Although …
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
… imprints during the acquisition of germline totipotency. However, we find that the remaining crosslink repair-deficient PGCs undergo the major hallmarks of epigenetic reprogramming. Furthermore, we demonstrate the both XPF-ERCC1 and Fanconi-mediated DNA crosslink repair are dispensable for …
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Characterization of germ cell development in free-living and parasitic flatworms
… a deeper understanding of mechanisms underlying totipotency, infertility, tumorigenesis, evolutionary development, and even pathogenesis. Here we study germ cells in the context of both free-living and parasitic flatworms. We use the freshwater planarian Schmidtea mediterranea to understand the …
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Genesis of the human germline
… eventually develop into sperm and ova, generate totipotency at fertilisation, and transmit genetic and epigenetic information for development. Since direct studies on early human embryos are not feasible, I used an established human pluripotent stem cell-based in vitro model for early human …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
… the co-option of its LTR as a promoter for totipotency genes. In the present work, we describe the analysis and reconstruction of an infectious ancestral MuERV-L (ancML) sequence through paleovirological analyses of MuERV-L elements in the mouse genome. The resulting ancML sequence was …
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ESTABLISHMENT IN CULTURE OF MOUSE AND HUMAN STEM CELLS WITH EXPANDED FATE POTENTIAL
The zygote and blastomeres of cleavage stage mouse embryos have the capacity to differentiate to the embryonic and both extra-embryonic lineages and are considered functionally totipotent. Until now, it has not been possible to establish stable cell lines that resemble these totipotent-like cells. …