Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Topotecan"”.
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Factors Influencing Topotecan CNS Penetration in Mouse Models
Camptothecin analogs such as topotecan are currently tested in clinical trials for brain tumors. However the clinical outcome is far below the expectations, which are derived from the promising preclinical studies. This discrepancy could be partially attributed to the presence of two barrier …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
<p>Increasing evidence suggests that inhibition of vascular endothelial growth factor (VEGF) can transiently normalize tumor vasculature, thereby improving delivery of systemic chemotherapy. Bevacizumab (BEV), an anti-VEGF antibody, has been shown to transiently normalize tumor vasculature by …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… are under development. The camptothecin analogs topotecan and irinotecan have been identified as successful cytotoxic agents. For topotecan, pharmacokinetically guided dosing to achieve a systemic exposure associated with preclinical anti-tumor activity in neuroblastoma xenograft models is …
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Untersuchungen zur Interaktion zwischen einer adenoviral-vermittelten Gentherapie und einer Chemotherapie mit Topotecan in etablierten humanen Ovarialkarzinom-Zelllinien
… adenoviralvermittelten Gentherapie und einer Topotecan-Behandlung in-vitro untersucht. Es wurde ein adenoviraler Vektor verwendet, der anstelle eines therapeutischen Gens das Reportergen lacZ (beta-Galaktosidase) unter der Kontrolle des konstitutiv aktiven Promotors RSV exprimierte. Der …
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Interrogating DNA replication stress and DNA damage responses via phenotypic and functional CRISPR/Cas9 screens
… cells treated with the topoisomerase I poison topotecan. This dissertation describes two distinct resistance mechanisms in Atm-/- cells towards TOP1 inhibitors, resulting from the inactivation of the non-homologous end-joining (NHEJ) machinery or alternatively the absence of the BRCA1-A …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… found form these studies that the combination of topotecan and carboplatin was effective. However both drugs cause myelosuppression and therefore administrating both of these drugs systemically is not possible. An alternative effective therapy in the clinic was the use of a subconjunctival …
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Problematika lokálních a celkových vedlejších účinků cytostatik při jejich experimentálním intraokulárním a periokulárním podání
… zhodnotit lokální ocní toxicitu karboplatiny a topotecanu na modelu králicího oka po její periokulární a intravitreální aplikaci. 2. Zhodnotit klinickou použitelnost nového zpusobu intravitreální aplikace chemoterapeutik transkorneální cestou. Materiál a metodika: In vivo experiment probíhal na …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… the synergistic effect of the nutlin-3a and topotecan combination on neuroblastoma cell growth, to assess the effect of nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the disposition of nutlin-3a in the mouse plasma and multiple tissues.</p> <p>Activating the p53 …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
… uptakes of three anticancer drugs (etoposide, topotecan and vinblastine) were observed in the presence of moxifloxacin across model cell lines suggesting moxifloxacin mediated evasion of efflux pumps. Significant reductions in efflux ratio of these anticancer agents were also observed in the …
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Nanoparticle based chemotherapy for pulmonary drug delivery in treating lung cancer
… to evaluate the effectiveness of cisplatin and topotecan (TPT) as a double therapy or as triple therapy with radiation. This include using a variety of molecular biology techniques to establish the cell kill potential of cisplatin in combination with TPT and radiation therapy on human lung …
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The Role Of Ubc9 In Drug Resistance And Its Expression Regulation In Cancer Cells
… sensitized cells to DNA damaging agents such as topotecan and doxorubicin as well as non-DNA-damaging agents such as paclitaxel and vincristine. Furthermore, we elucidated that Gam1-mediated cell growth inhibition was associated with induction of apoptosis. In particular, Gam1 induced caspase-3 …