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Showing 1 to 6 of 6 for “"Topoisomerase inhibitors"”.

  1. Fragments of microcin B17 as a source of new topoisomerase inhibitors

    Collin, FredericUniversity of East Anglia2010

    east-anglia Repository record

  2. DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS

    Lehman, Christine LehmanWake Forest University2016

    … in the generation of RET/PTC rearrangements. DNA topoisomerases I and II maintain structural integrity by recognizing and cleaving DNA secondary structures such as those at fragile sites. Co-treatment of human thyroid cells with APH and topoisomerase inhibitors significantly altered APH-induced …

    wfu Repository record

  3. Anticancer Potential of Soy Peptides

    Wang, WenyiUniversity of Illinois at Urbana-Champaign2015

    … most common type of cancer in children. Various topoisomerase inhibitors are currently used in the treatment of leukemia. Epidemiological studies have associated soy consumption with lowering cancer risk. However, the anticancer potential and mechanism of soy peptides have not been fully …

    uiuc Repository record

  4. Functional Characterisation of a RECQL4 Mutation in Rothmund-Thomson Syndrome

    Wu, TianyiUniversity of Cambridge2020

    … increased sensitivities to DNA alkylators and topoisomerase inhibitors, and mild sensitivities to DNA crosslinkers and PARP inhibitors, a sensitivity profile suggestive of defects in DNA double-strand break (DSB) repair. When further assayed using flow cytometric GFP reporters, the Mut-2 clones …

    cambridge Repository record

  5. Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer

    Singhal, MitaliUniversity of Bradford2025

    … for treatment. Mitoxantrone (MTX), a topoisomerase II inhibitor belonging to the anthracenedione class, is used in BCa therapy. This thesis investigates the potential and mechanism of action of the MTX analogue KP71 and two metal organic frameworks (MOFs), UiO-66 and UiO-66-NH2, loaded …

    bradford Repository record

  6. Patterns of post-translational histone modifications, chromatin condensation and DNA fragmentation during apoptosis

    Beisel, Nadine2012

    … Zellen analysiert, nachdem diese mit Topoisomerase Hemmern behandelt wurden. Die Ergebnisse zeigen eine Hyperphosphorylierung am Histon H2AX Serin 139 zehn Minuten nach Induktion und eine starke Ubiquitylierung am Histon H2A sechs Stunden nach Induktion. Untersuchungen zur Freisetzung …

    goettingen Repository record