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Showing 1 to 4 of 4 for “"Topoisomerase 2"”.
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Investigating the mitotic roles of Topoisomerase 2 Alpha and Topoisomerase 2 Beta-Binding Protein 1 in the maintenance of chromosome structure and genome stability
Type II Topoisomerases are essential, evolutionarily conserved proteins, important throughout the cell cycle. They act by generating a transient double-stranded DNA break in one molecule and manoeuvring a second DNA segment through the resultant gap. This ability to catenate and decatenate DNA …
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Stabilization of Topoisomerase 2 Mutants Initiates the Formation of Duplications in DNA
<p>Topoisomerase 2 (Top2) is an enzyme that helps maintain genome integrity by resolving topological structures that arise during cellular processes such as replication and transcription. To resolve these structures, a Top2 dimer creates a transient double-strand break (DSB) in the DNA. Each …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
… compound, CX-5461, was discovered to inhibit Topoisomerase 2 as its primary mechanism of action, instead of the previously assumed RNA polymerase I inhibition. Finally, new functional genetic tools were developed for examining tumor progression and therapeutic response both in vitro and in …
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Identification and Characterization of Factors Involved in Sodium Selenite Toxicity
… Hmo1. As Hmo1 has been shown to interact with Topoisomerase 2 (Top2) to organize chromatin organization, I further elaborated the role of Top2 in SeL mediated DNA damage formation. Notably, my results suggest that SeL-dependent chromosome fragmentation is enhanced in cells lacking Top2 …