Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Topoisomerase 1"”.
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Identification and Characterization of Modulators of Chemotherapeutic Response in Mouse Models of Cancer
… in vitro screening experiments identified topoisomerase 2A levels as critical determinants of doxorubicin response. Subsequent follow-up experiments - including one demonstrating doxorubicin sensitization in the presence of topoisomerase 1 shRNAs - revealed important insights into …
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A Mutated Peptide Database for the Analysis of Proteomic Mass Spectrometry Data
… others. Mutations in the oncogene KRAS, DNA Topoisomerase 1 (TOP1), and TGF-beta receptor type 2 (TGFBR2) represent only a small sample of the mutations that were detected. Overall, the XMAn v3 database proved to be very useful in enabling the identification and characterization of missense …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… and a lack of drug substance. <br/><br/>The topoisomerase 1 inhibitor camptothecin was chosen as the payload of choice in the nanoparticle candidate going forward. Camptothecin had a number of advantages 1) it showed favourable entrapment using the single emulsion method given its hydrophobic …
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Investigation of Genomic Instability Induced By G-Quadruplexes In The Absence of Functional to poisomerase 1 In Yeast
<p>Topoisomerase 1 (Top1) is an enzyme that removes transcriptionally generated negative supercoils by binding and nicking DNA. Since transcription of guanine-rich DNA leads to the formation of G-quadruplex (G4) structures, Top1’s function likely suppresses G4-formation. In support of this, Top1 …