Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Topical drug delivery"”.
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Phonophoresis and topical drug delivery
… gel. The application of heat alone increased drug migration by a similar magnitude as the ultrasound, indicating that ultrasonic heating directly increases the thermodynamic potential for diffusion. In the second experimental system, whole rat skin was pre-sonicated and then examined for …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that affect the posterior segment. Etoposide (ET) is used for treatment of retinoblastoma and fluocinolone acetonide (FA) is used for treatment of uveitis. …
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Investigation of drug ionic liquid salts for topical delivery systems
Pharmaceutical companies and FDA (Federal Drug Administration) rules rely heavily on crystalline active pharmaceutical ingredients delivered as tablets and powders in the form of neutral compounds, salts and solvates of neutral compounds and salts. About half of all drugs sold in the market are in …
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Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment
… to its side effects, its use is highly limited. Topical delivery of acitretin may decrease the systemic toxicity and increase the drug’s bioavailability at the pathological site. However, this approach has some limitations. The decrease in skin integrity due to psoriasis could lead to escape of …
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The rational design of dermatological formulations
… the role of the formulation components in topical drug delivery it is necessary to separate the various contributing factors, these include thermodynamic activity effects, changes in the ionisation state of the permeant and alteration of the membrane properties. Three model permeants, …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… on the development of a new way to commence drug therapy to reduce the side effects of the treatment. Our work is based on the studies of the genotoxicity of the drug Secukinumab in its bulk and liposome form using comet and micronucleus assays on lymphocytes. The results from both assays …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… on the development of a new way to commence drug therapy to reduce the side effects of the treatment. Our work is based on the studies of the genotoxicity of the drug Secukinumab in its bulk and liposome form using comet and micronucleus assays on lymphocytes. The results from both assays …
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Nanostructures for protection and vehiculation of bioactive molecules
… applications. For example, the most promising drug delivery systems belong to the colloidal domain and, particularly, to the soft matter. Indeed, a growing effort in the discovery of innovative therapies has led to an increasing demand for drug delivery vehicles whose capability should go far …
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Development and Evaluation of a Niosome Carrier for Topical Use of Antioxidant
… potential antioxidant properties. However, topical application of this antioxidant encounters several challenges. Firstly, the skin barrier which mostly lays in the stratum corneum (SC) prevents the transporting of external substance into the skin and thus limits the reservoir of the …