Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Topical delivery"”.
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Investigation of drug ionic liquid salts for topical delivery systems
… salts, particularly in the field of transdermal/topical drug delivery. Due to the multifunctional nature of these salts they could allow generation of new pathway to manipulate the transport and deposition behaviour of the drug molecule. It is this modular approach of IL that forms the basis of …
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New lipid nanovesicles as topical delivery sistems for ant-inflammatory drugs
… formulate new vesicular carriers to optimize the topical delivery of anti-inflammatory drugs: diclofenac, quercetin and curcumin. In the first work concentrated and interconnected penetration enhancer containing vesicles (PEVs) are proposed as carriers for dermal delivery of diclofenac. PEVs were …
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Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment
… to its side effects, its use is highly limited. Topical delivery of acitretin may decrease the systemic toxicity and increase the drug’s bioavailability at the pathological site. However, this approach has some limitations. The decrease in skin integrity due to psoriasis could lead to escape of …
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Granular Hydrogels for Localized Nanoparticle Delivery
… clinical and socioeconomic burden, yet effective topical delivery of advanced therapeutics remains a major challenge. Nucleic acid–based therapies hold enormous promise for locally modulating gene expression and restoring skin homeostasis, but their translation is limited, among others, by the …
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Topical Therapies for the Management of Recalcitrant Chronic Rhinosinusitis
This thesis encompasses research investigating topical therapies to improve the management of recalcitrant chronic rhinosinusitis (CRS). Chapter one of this thesis reviews the current literature pertaining to CRS including its aetiopathogenesis and the role of the sinonasal microbiome. It also …
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Soft [beta]-adrenoceptor agonists for topical use in psoriasis
… a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictable and controllable In vivo destruction (metabolism) to non-toxic …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
Like many topically applied formulations, diclofenac (DF) preparations face delivery challenges due to the highly effective skin barrier. This research explored a novel amino acid-based ion pairing strategy to enhance percutaneous DF delivery through rational counterion selection and solvent …
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Development of a topical epigallocatechin gallate (EGCG) formulation
… it is a promising candidate for use in topical formulations for skin cancer prevention. The overall objective of this dissertation was to develop a formulation suitable for the topical delivery of (EGCG). A high-performance liquid chromatography (HPLC) assay was developed to evaluate the …
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Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
… in improving prednisolone absorption post oral delivery. LDP and DLP demonstrated higher aqueous solubility relative to prednisolone. Moreover, LDP and DLP prodrugs demonstrated higher potential to overcome P-gp mediated cellular efflux relative to prednisolone. Transepithelial permeability of …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… test the behaviour of polymersomes, a novel drug delivery system, in three dimensional tissues. Polymersome distribution and penetration in the tissue engineered models was examined over time, to investigate the potential of polymersomes to deliver therapeutic agents into and/or across the oral …
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Formulation, characterisation and topical application of oil powders from whey protein stabilised emulsions
… research has been performed on oil powders for topical delivery. The aim of this project was to investigate the release characteristics of oil powder formulations, as well as their dermal and transdermal delivery properties. Whey protein-stabilised emulsions were used to develop oil powders. …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… suspended in a biocompatible gel for topical delivery of therapeutic agents commonly employed in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of dipeptide monoester prodrugs of ganciclovir (GCV) including …
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Antimicrobial wafers as a novel technology for infection control in chronic wounds.
… and production of exudate. The application of topical, broad spectrum antimicrobial compounds embedded in absorbent dressings has been shown to control bioburden and improve healing. Lyophilised, biopolymeric antimicrobial wafers can offer a contemporary, user-friendly, self-adhesive and …
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The use of nanotechnology in enhancing the efficacy of cosmetic actives of natural origin
… certifications, as well as the merits of skin delivery systems in topical delivery. In this study, an ester form of Vitamin E, d-a-tocopheryl acetate (TA) , was chosen as a model natural active. Obtained from natural sources, vitamin E alcohol (tocopherol) has undergone esterification process …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… promise for further investigation as potential topical treatments for cutaneous diseases. Moreover, this is the first study to report the activity of these cationic compounds against L. mexicana. Guanidino, amidoamine, and quaternary ammonium compounds show potential for use in topical …
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Nanocarriers for drug targeting and improved bioavailability
… debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor …