Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 577 for “"Topical"”.
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Topical pharmacokinetics for a rational and effective topical drug development process
Topical drugs are not developed by the same process as oral drugs. The process is more uncertain and contains gaps. This leads to a poor discharge of risks before going to the clinical phases. The topical drug development process is reviewed in the introduction of the thesis. In particular, past …
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Myocardial Topical Negative Pressure
… myocardial microvasular blood flow by applying a topical negative pressure source directly onto the myocardium. Topical negative pressure is a relatively new wound healing technique. When used in wound therapy, topical negative pressure has been shown to increase microvascular blood flow, to …
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Phonophoresis and topical drug delivery
In this study, investigations into phonophoresis were conducted by employing 3 distinct in vitro models. The aim of the first model was to evaluate the effect of ultrasound on the migration rate of different classes of molecules through agar gel. The derived data suggested that small, relatively …
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Treatment of prepubertal labial adhesions: a randomized, double-blinded trial comparing topical emollient versus topical estrogen
… labial fusion, urinary retention. Although topical estrogen had traditionally been considered first-line therapy, this method of treatment can be associated with alarming side effects in prepubertal girls including breast budding and vaginal bleeding. This clinical study aimed to assess the …
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Topical outline of highway traffic control
Thesis--Michigan Agricultural College, 1924
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A Topical History of Elementary Mathematics
The problem in this thesis is to present a brief history of topics in elementary mathematics written in language that is within the comprehension of, and fitted to the interest of the average high school pupil. Much mathematical subject matter that has been considered too difficult to be grasped by …
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Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses
… the effects of three medical treatments, topical oxytetracycline, topical prednisolone acetate, and systemic flunixin meglumine, on the activity of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of …
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Studies on the Formulation of Topical Corticosteroids
The stabilities of betamethasone-17-valerate and hydrocortisone-17-butyrate have been investigated. It has been shown that the 17-esters undergo acyl migration to the 21-isomers. These 21-isomers hydrolyse to the free alcohols which further degrade to other products. In order to elucidate the …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… suspended in a biocompatible gel for topical delivery of therapeutic agents commonly employed in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of dipeptide monoester prodrugs of ganciclovir (GCV) including …
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Investigation of novel topical therapeutics for chronic rhinosinusitis
… treatments are saline nasal irrigation and topical corticosteroids, with the addition of courses of systemic antibiotics and corticosteroids when indicated. If these therapies do not yield a satisfactory improvement in symptoms, functional endoscopic sinus surgery (FESS) may be performed, …
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Development of a topical epigallocatechin gallate (EGCG) formulation
… it is a promising candidate for use in topical formulations for skin cancer prevention. The overall objective of this dissertation was to develop a formulation suitable for the topical delivery of (EGCG). A high-performance liquid chromatography (HPLC) assay was developed to evaluate the …
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Topical Therapies for the Management of Recalcitrant Chronic Rhinosinusitis
This thesis encompasses research investigating topical therapies to improve the management of recalcitrant chronic rhinosinusitis (CRS). Chapter one of this thesis reviews the current literature pertaining to CRS including its aetiopathogenesis and the role of the sinonasal microbiome. It also …
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Topical content in sexuality education and sexual health outcomes.
… relationship between sexual health outcomes and topical content in sexuality education, controlling for race, biological sex, low socioeconomic status, and religiosity. Results indicated increasing topical content in sexuality education had a positive effect on knowledge acquisition and …
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Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of …
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Soft [beta]-adrenoceptor agonists for topical use in psoriasis
… a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictable and controllable In vivo destruction (metabolism) to non-toxic …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… formulation will be administered in the form of topical eye drops.
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Investigation of drug ionic liquid salts for topical delivery systems
… salts, particularly in the field of transdermal/topical drug delivery. Due to the multifunctional nature of these salts they could allow generation of new pathway to manipulate the transport and deposition behaviour of the drug molecule. It is this modular approach of IL that forms the basis of …
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The Effect of Topical Tranexamic Acid Application on Melasma Treatment
… investigate the effects and action mechanism of topical TA in the treatment of melasma. Material and methods: Twenty three healthy Korean females with melasma were enrolled, and applied 2% TA formulation on the whole face for 12 weeks. Pigmentation and erythema were objectively assessed using …
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Treatment of Ischemic Equine Jejunum with Topical and Intraluminal Carolina Rinse
… of this study was to show that CRS applied topically and intraluminally could prevent immediate reperfusion injury after low flow ischemia or distention in the equine jejunum. Materials & Methods: Two groups of 5 horses were used to evaluate CRS treatment after low-flow ischemia (Group 1) …
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