Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"TopBP1"”.
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Investigating the mitotic roles of Topoisomerase 2 Alpha and Topoisomerase 2 Beta-Binding Protein 1 in the maintenance of chromosome structure and genome stability
… Topoisomerase 2 beta-binding protein 1 (TOPBP1) is conserved throughout eukaryotes and has nine BRCT (BRCA1 C-terminus) domains which allow it to interact dynamically with various phospho-proteins. It was originally identified, through a yeast two-hybrid screen, as a factor interacting …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… p53 stability, and binding and recruitment of TopBP1 to sites of replication stress to maintain ATR signaling.</p> <p>The stability of p53 is largely dependent on its negative regulator, the MDM2 ubiquitin E3 ligase. Here, we provide evidence that in addition to its role as an upstream …
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Identification of TICRR, a novel checkpoint and replication regulator
… in a novel gene that we have named ticrr (for TopBP1 interacting, checkpoint and replication regulator). The loss of ticrr impairs DNA replication and disrupts the S/M checkpoint, leading to premature mitotic entry of cells with partially replicated genomes and mitotic catastrophe. Therefore, …
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The interaction of CtIP with DNA damage response proteins
… proteins containing BRCT domains: 53BP1, MDC1, TopBP1 and NBS1. The binding sites on all of these proteins have been mapped establishing which regions of CtlP interact directly with 53BP1, MDC1, TopBP1 and NBS1 and vice versa. This implies that CtlP is involved in the DNA damage response on many …
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Characterisation of non-essential genes required for survival under conditions of DNA stress
… that fits the multifunctional description, is TopBP1. Rad4 is the Schizsaccharomyces pombe (S. pombe) TopBP1 homologue that is essential for the initiation of DNA replication, DNA repair as well as the activation of DNA damage checkpoint signalling. We have modelled conditions of replication …
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The Role of the Protein MTBP in DNA Replication
… of these proteins have been identified: TopBP1, for Dpb11, is essential for replication; Treslin, the Sld3 ortholog, is an essential S-CDK substrate that interacts with TopBP1 and is required for the CMG assembly; in human cells MTBP has been found associated with Treslin, and is involved …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… foci assembly of adaptor proteins such as TopBP1, Brca1, activation of Chk2 and Chk1, phosphorylation of p53 at Ser15 and induction of p53 target genes, cell cycle checkpoints and DNA repair of ssDNA breaks. These findings were confirmed by c-Abl reconstitution. Further studies indicate …
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53BP1 and double-strand break repair pathway choice in cancer
… We propose that the functional sequestration of TOPBP1 may be responsible for these chromosomal mis-segregation defects. The mechanism by which 53BP1 (together with RIF1 and MAD2L2) promote NHEJ remains elusive. Genome instability in HR-defective cancers, principally those harbouring a mutation …