Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tom1"”.
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Binding properties of adaptor proteins Tollip and Tom1
Adaptor proteins, like Tollip and Tom1, facilitate cellular cargo sorting through their ubiquitin-binding domains. Tollip and Tom1 bind to each other through their TBD and GAT domains, respectively, whereas Tollip interacts with phosphatidylinositol-3-phosphate (PtdIns(3)P)-containing endosomal …
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Molecular mechanisms of TOM1-mediated protein trafficking in health and disease
TOM1 is an adaptor protein involved in the alternative ESCRT-0 pathway. TOM1 functions by recognizing the ubiquitin moieties on internalized receptors and sorting them towards the degradative arm of the lysosomal system. Two mechanisms of TOM1 aberrant function were uncovered: one mechanism due to …
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Structural and Functional Basis for the Autoregulation of the Adaptor Protein TOM1
Target of Myb 1 (TOM1) is an endosomal adaptor protein that plays a role in cargo membrane trafficking for degradation by serving as an alternative endosomal sorting complex required for transport component. TOM1 has also been shown to serve as a novel phosphatidylinositol 5-phosphate (PtdIns5P) …
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Proteomic Identification of Histone Post-Translational Modifications Induced By Dna Double-Strand Breaks and Novel Proteins Involved In The Dna Damage Response
… mRNA export protein Yra1 and the HECT E3 ligase Tom1. Each of these proteins was required for resistance to radiomimetics. Yra1 and Def1 were required for DSB repair per se, while Sit4 was required for rapid inactivation of the DNA damage checkpoint after DSB repair. Thus, our unbiased proteomics …
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ELUCIDATION OF REGULATORY MECHANISMS OF TRANSCRIPTION AND COUPLED mRNA EXPORT
… via HECT domain-containing E3 ligases like Tom1 and Rsp5. My work has revealed the role of an F-box protein (Mdm30) component of RING domain-containing SCF (Skp-Cullin-F-box) family of E3 ligases in mRNA export, thereby implicating the role of ubiquitylation in export via non-HECT E3 ligase …
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Scanning Probe Microscopy Study of Molecular Nanostructures on 2D Materials
… mechanism relies on complex forming between Tom1 and the cargo sorting protein, Toll interacting protein (Tollip). The induced conformational change in Tollip triggers its dissociation from the lipid membrane and commitment to cargo trafficking. This collaborative study aims at characterizing …
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The role of abscisic acid in the defence response of tomato (Solanum lycopersicum) to the necrotrophic pathogens Botrytis cinerea and Erwinia chrysanthemi
… expression in sitiens and wild-type tomato with TOM1 microarrays revealed that defence-related transcript accumulation prior to infection is higher in sitiens than in wild type. Moreover, further elevation of defence gene expression after pathogen attack is also stronger in sitiens, both in …