Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Tollip"”.
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Binding properties of adaptor proteins Tollip and Tom1
Adaptor proteins, like Tollip and Tom1, facilitate cellular cargo sorting through their ubiquitin-binding domains. Tollip and Tom1 bind to each other through their TBD and GAT domains, respectively, whereas Tollip interacts with phosphatidylinositol-3-phosphate (PtdIns(3)P)-containing endosomal …
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Ubiquitin Modulates Tollip's PtdIns(3)P Binding and Dissociates the Dimeric State of C-Terminal Cue Domain
… the function of the Toll-interacting protein (Tollip), which is an effector protein in the innate immune signaling pathway and an adaptor protein for endosomal trafficking. We have demonstrated that the central C2 domain of Tollip preferentially interacts with phosphoinositides with moderate …
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… pathogen clearance. Toll-interacting protein (Tollip) is an intracellular mediator of several immune mechanisms. Tollip negatively regulates TLR activation, and acts as a mediator of autophagy and endosomal transport. These mechanisms are involved in processes such cytokines expression, antigen …
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Molecular mechanisms of TOM1-mediated protein trafficking in health and disease
… these signaling endosomes also attracts TOM1 and TOLLIP by their affinities for PtdIns(5)P. At physiological conditions, TOM1 and TOLLIP show a low affinity for PtdIns(5)P, allowing the complex to perform cargo trafficking functions at the surface of early endosomes through their ability to bind …
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Modulation of Neutrophil Functions and Anti-Tumor Immune Responses by Innate Suppressors
… of my thesis is to identify the role of Tollip, a novel TLR signaling adaptor molecule, in modulating neutrophil functions by suppressing the inflammatory signaling pathway. Preliminary data from our lab suggest Tollip deficient neutrophils may be programed to exhibit enhanced anti-tumor …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… cascade called toll-interacting protein (tollip) has been demonstrated to induce hyporesponsiveness in the gastrointestinal tract in the presence of bacteria. So far, tollip has not been demonstrated in the respiratory tract. AIMS: To compare the responses of the upper and lower …
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. While Tollip may serve …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
… ZO-1 and the endogenous TLR signal regulator, Tollip, were suppressed upon co-culture with pro-inflammatory M1 macrophages paralleled by a suppression of IL-10 and up-regulation of TNF-α and IL-8. In the presence of LPS, HK-LF enhanced TEER, ZO-1 and partially rescued Tollip expression, whereas …
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Scanning Probe Microscopy Study of Molecular Nanostructures on 2D Materials
… cargo sorting protein, Toll interacting protein (Tollip). The induced conformational change in Tollip triggers its dissociation from the lipid membrane and commitment to cargo trafficking. This collaborative study aims at characterizing the dynamic interaction between Tollip and the lipid …
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… at low doses, mice deficient in IRAK1 and tollip, key mediators or proinflammatory LPS signaling, were used to study IL-4, ATRA, and LPS crosstalk. LPS suppression of arginase 1 was found to be dependent on IRAK1 and tollip, but only at low doses of LPS.
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Die Hemmung der Bildung des Interleukin-1-Rezeptorkomplexes als redoxregulierter antiinflammatorischer Mechanismus
… auf mRNA- und Proteinebene die Expression von Tollip, welches durch PCR bzw. Western Blot nachgewiesen wurde. Tollip, ein negativer Regulator in TLR/IL-1RI-Signalkaskaden, könnte somit nach Induktion die IRAK-Aktivierung unterdrücken. Die Sulforaphan-abhängige Induktion der Tollip-Expression …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… by ELISA and RT-PCR, whereas TLR-2, TLR-4, Tollip, SOCS3, STAT3 and TRAIL by RT-PCR. This study revealed that, first, live C28 and MS13 stimulated the proinflammatory cytokine by M2-like macrophages as well as the anti-inflammatory cytokine in a homeostatic status; whereas in an …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… p62 indicative of the suppression of autophagy. Tollip and Interleukin-1 receptor-associated kinase 3 (IRAK-M) appear to be critical regulators in this process. Collectively, these studies show that low-dose endotoxemia is capable of causing persistent cellular stress, not observed in the …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… of negative regulators, such as IRAK-M and Tollip. In addition, MΦ subsets differentially responded to inflammation induced by pro-inflammatory cytokines, TNFα and IL-1β in mono- and co-culture models. In conclusion, tolerisation induced in MΦs is presented by the suppression of …
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The Association Between The Il-1 Pathway
… Those genes are IL-1RI, IL-1RAcP, IL-1RA, MYD88, TOLLIP, IRAKs, MEKK1, MEK3, MEK6, JNK, P38, c-JUN, ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, …