Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Toll-like receptors (TLRs)"”.
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. There have been reported that keratinocyte TLRs represent the first barrier against exogenous pathogens in human skin. Recently, it was reported that melanocytes not only function melanin synthesis …
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Clinical approaches for understanding the expression levels of pattern recognition receptors in otitis media with effusion
… this study we evaluated the expression levels of Toll-like receptors (TLRs) -2, -4, -5, -9, and nucleotidebinding oligomerization domain-containing proteins (NODs) -1 and -2, all of which are related to bacterial infection in pediatric patients with otitis media with effusion (OME). METHODS: The …
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Characterizing the function of human toll-like receptor 10
Toll-like Receptors (TLRs) are important constituents of the immune response, capable of both protecting the host from danger and inciting harm from within. In this Thesis, I present evidence that the last human orphan toll-like receptor, TLR10, has a unique function that differs from its other …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… may sense alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit different responses are not …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… revealed that the bacterial Thoeris system, a Toll-interleukin 1 receptor (TIR) domain-based immune system in bacteria, detects specific phage capsid proteins [4]. This recognition event triggers the production of a signaling molecule that activates the depletion of an essential metabolite, …
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Unravelling the anti-inflammatory mechanisms of dietary fatty acids
… component of the innate response, which express toll-like receptors (TLRs). Ligation of TLR4, by its ligand lipopolysaccharide (LPS), results in macrophage activation. This study demonstrates that the n-6 derivative, conjugated linoleic acid (CLA) and n-3 PUFA, DHA and EPA differentially modulate …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
… patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation of inflammatory signaling pathways potentially resulting in periodontal …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… molecular patterns (PAMPs) activating Toll-like receptors (TLRs) on host cells. I investigated the role that PAMPs play in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental influences contribute to the pathogenesis of MS. I used …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
Toll-IL-1R homology (TIR) domains are found within adaptor proteins involved in the signaling of Toll like receptors (TLRs) and Interleukin 1 receptor (IL1R) families. Previous work by our lab identified a TIR domain in the protein B cell adaptor for phosphoinositide 3-kinase (BCAP) and determined …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
The activation of Toll-like receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly …
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Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling
… is composed of an extracellular Fibronectin III-like (FnIII) domain, a single transmembrane domain and an intracellular similar expression to FGF genes (SEF)/IL-17R (SEFIR) domain, which is crucial for IL-17 signalling and is homologous to the TIR domains of Toll-Like Receptors (TLRs). Here, we …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
… series of pathogen associated molecular pattern receptors such as the Toll-like receptors (TLRs) to detect and respond to invading microorganisms. The different TLRs play a pivotal role in the first line of defence by recognising the type of pathogenic threat encountered and by responding in …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… the recognition of potentially harmful stimuli, Toll-like receptors (TLRs) initiate the innate immune response and induce the expression of hundreds of immune and pro-inflammatory genes. TLRs are critical in mounting a defence against invading pathogens however, strict control of TLR signalling …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognizing conserved structural features of bacterial or viral origin and regulate the initiation of the innate immune response. TLR signaling is subjected to a dynamic and complex regulation that remains poorly understood. Our research …
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Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury
… innate immunity through the engagement of Toll-Like Receptors (TLRs) by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Stimulation of TLR4 induces distinct patterns of gene expression, which not only leads to the …
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Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
… found to be partially coupled. Activation of Toll-like receptors (TLRs) by purified parasite components increased internalization of parasitized erythrocytes, but uptake of parasitized erythrocytes did not require TLRs, nor did it trigger cytokine production via TLRs or other receptors. Two …
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
… by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of toxoplasmosis we have identified the presence of a non-lymphoid source of IFN-γ that was particularly evident in the absence of TLR-mediated recognition of Toxoplasma gondii. Flow-cytometry and …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… evidence suggests that pattern recognition receptors of the innate immune system such as the toll-like receptors (TLRs) are involved. In the present study, we tested the central hypothesis that TLR4 is the link between reactive oxygen/nitrogen species (RONS), oxidative stress and …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… the presence of low-density lipoprotein (LDL). Toll-like receptors (TLRs) play a central role for macrophages to detect pathogens and elicit inflammatory responses.</p> <p>Data presented in this study have furthered our understanding of the different mechanisms of foam cell formation induced by …
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Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… for their potential therapeutic application. Toll-like receptors (TLRs) recognize microbe-associated molecular patterns (MAMPs) and play a critical role in shaping microbial-specific innate and adaptive immune responses. Following ligand engagement, TLRs trigger a complex network of signalling …
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