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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 39 for “"Toll-like receptor 4 (TLR4)"”.

  1. Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins

    Kelley, StacyUniversity of Illinois at Urbana-Champaign2013

    … pattern recognition complex comprised of Toll-like receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is …

    uiuc Repository record

  2. Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts

    Alsousi, AsmaaUniversity of Missouri -- Kansas City2018

    … Evidence suggests that oxidant-induced Toll-like receptor 4 (TLR4) activation plays a significant role in initiating “sterile” inflammation. Here, we investigate for the first time the role of RATM-induced oxidant stress in the molecular mechanism of the pathogenesis of RA. Potassium …

    umkc Repository record

  3. Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation

    Kowalski, Elizabeth AshleyVirginia Tech2017

    … circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external …

    vt Repository record

  4. Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines

    Park, Hyun J2011

    … Further, knowing mBD2’s link with CC chemokine receptor 6 (CCR6) and Toll-like receptor 4 (TLR4) we note that this enhanced class I T cell expansion is CCR6 independent but TLR4 dependent. With anti-tumor responses desired, we demonstrate in tumor protection experiments with mice, compelling …

    uthsc Repository record

  5. Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy

    Netzel, LaurenCreighton University2020

    … in KO mice. Markers of inflammation activated in toll-like receptor 4 (TLR4) pathway are associated with apnea and respiratory failure, therefore we determined whether an inflammatory pathology is apparent in lung tissue in older, KO mice that are at high-risk for SUDEP and wildtype (WT) control …

    creighton Repository record

  6. Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages

    Smith, Tyler Joseph

    … numerous pro-inflammatory mediators through Toll-like receptor 4 (TLR4) binding to lipopolysaccharide (LPS). IL-10 acts on these cells through the induced expression of genes that inhibit expression of select TLR-induced pro-inflammatory genes. Our understanding of the mechanisms by which …

    mo-state Repository record

  7. Palmitic Acid Activation of Dendritic Cells: Implications for Type 2 Diabetes

    Nicholas, Dequina Angelina

    … of monocytes into dendritic cells likely accounts for the increased number of dendritic cells observed in the adipose tissue of type 2 diabetic patients. We have demonstrated this differentiation process is regulated in part by a major reduction of linker histone proteins. In …

    loma-linda Repository record

  8. The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation

    Ali, Mostafa M.Virginia Tech2017

    Toll like receptor-4 (TLR4) is a transmembrane inflammatory receptor expressed ubiquitously on the cell surface of immune cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle …

    vt Repository record

  9. Endotoxin-induced microRNA expression in equine peripheral blood mononuclear cells

    Parkinson, Nicholas J.Virginia Tech2016

    … response to lipopolysaccharide (LPS) mediated by toll-like receptor 4 (TLR4) contributes substantially to the morbidity of equine gastrointestinal disease, neonatal sepsis and other diseases. MicroRNAs (miRNAs), small non-coding RNA molecules acting as post-transcriptional regulators of gene …

    vt Repository record

  10. Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex

    Chhibber, JyotiUniversity College Cork2013

    … play an important role in controlling receptor-mediated intracellular signalling events, which have a central role in Alzheimer’s disease, cancer progression and immune surveillance. It has previously been reported that the Interleukin-1 receptor, type 1, (IL-1R1) is a substrate for …

    cork Repository record

  11. Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours

    Jacobsen, Jonathan Henry Webster2017

    … system, specifically, an innate immune receptor (Tolllike receptor 4) in mediating these phenomena. Toll-like receptor 4 (TLR4) is a pattern recognition receptor that detects conserved molecular epitopes expressed on pathogens, danger molecules and drugs of abuse. In response to alcohol …

    adelaide Repository record

  12. The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis

    Jeong, Yun Seong2015

    … and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate ligands, including lipopolysaccharide (LPS), IL-1, and RANK ligand (RANKL). Recently, TRAF6 has also been shown to be involved in …

    uthsc Repository record

  13. Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling

    NGUYEN, THI NGOC TU2012

    … of the central nervous system. Activation of Toll-like receptor 4 (TLR4), the primary transducers of innate immune system, is critical in microglial functions. Especially, activation of microglia by lipopolysaccharide (LPS), a ligand for TLR4, has been extensively studied. It was previously …

    ajou Repository record

  14. TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?

    Kasmark, LeahVirginia Tech2017

    … on their cell membranes, which is recognized by Toll-like receptor 4 (TLR4). In cases where epithelial barriers are compromised or breached LPS has the potential to enter circulation and cause the inflammatory symptoms seen with endotoxemia. The objective of this study was to determine TLR4 …

    vt Repository record

  15. Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches

    Frigerio, FedericaThe Open University2017

    … in human epilepsy. Interleukin-1β (IL-1β)/IL-1Receptor type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental and clinical evidence showed that endogenous anti-inflammatory …

    the-open-u Repository record

  16. Impact of endotoxemia on ovarian signaling and function

    Dickson, Mackenzie2017

    … circulating LPS and that endotoxemia upregulates toll-like receptor 4 (TLR4) pathways, as well disrupt insulin signaling and steroidogenesis in the ovary. To test this central hypothesis, various animal models; pre- and post-pubertal gilts, as well as lactating cows, were exposed to HS and/or LPS …

    iastate Repository record

  17. Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.

    Chang, Charles A., 1991-Baylor University.2018

    … the loss of as much as 50% of the islet graft. Toll-like receptor 4 (TLR4) has been identified as a major pro-inflammatory mediator of sterile inflammation by sensing damage-associated molecular patterns (DAMPs) and compromising graft function, making it a putative therapeutic target. Here, we …

    baylor Repository record

  18. A novel bioinformatic approach for comprehensive genome scale analysis identifies key regulators of macrophage activation.

    Katz, SamuelUniversity of Cambridge2020

    … line of defense. Macrophage activation by the Toll-like Receptor 4 (TLR4) pathway is initiated with receptor binding of lipopolysaccharides (LPS) and culminates in a large-scale transcriptional response of the inflammatory gene program. Advancements in genome-wide screening technologies have …

    cambridge Repository record

  19. The Role of IRAK-1 in the Regulation of Free Radicals and Oxidative Stress during Endotoxemia

    Singh, NeerajVirginia Tech2010

    … production are not fully defined. Interleukin-1 Receptor associated kinase (IRAK-1), an intracellular kinase downstream of Toll-like Receptor 4 (TLR4) has been shown to contribute to the inflammatory cascade associated with LPS-TLR4 signaling pathway. However, its role in ROS production has not …

    vt Repository record

  20. Cellular Reprogramming in Skeletal Muscle after Repeated Exposures to Endotoxin

    Denko, Laura MichelleVirginia Tech2012

    … metabolic derangements have been linked to toll-like receptor 4 (TLR4), an innate immune system receptor, due to its role in proinflammatory pathways. Lipopolysaccharide (LPS), a gram-negative bacteria cell wall component, is the ligand for TLR4, and has been shown to be elevated in states …

    vt Repository record

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