Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Toll-like receptor 2"”.
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Regulatory Mechanisms Controlling Expression of the Toll-Like Receptor 2 Subfamily
… the post-translational localization of the receptor. In chapter five, I will summarize these findings and discuss the potential implications.
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. There have been reported that keratinocyte TLRs represent the first barrier against exogenous pathogens in human skin. Recently, it was reported that melanocytes not only function melanin synthesis …
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Molecular Characterization of Microbial Sensing by Members of the Human Toll -Like Receptor 2 Sub-Family
In summary, we have identified specific residues of TLR1 that play an essential role in mediating response to microbial agonists and defined a target region for therapeutic agents.
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
As pattern recognition receptors of the innate immune system, Toll-like receptors (TLRs) sense microbial components and mediate cell activation leading to protective inflammatory responses. TLRs are type-1 transmembrane receptors that are activated by forming dimers; an event driven by the …
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Innate immune recognition by human toll-like receptor 10 and other members of the toll-like receptor 2 subfamily
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2011-05-25T14:42:13Z Item is restricted until 2013-05-25T14:41:28Z
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… different mice strains to elucidate the role of toll-like receptor 2 (TLR2), TLR4, lymphocyte function antigen-1 (LFA-1), matrix metalloproteinases (MMPs) and Rho-kinase as well as nuclear factor of activated T-cell (NFAT) signaling in AP. We found that TLR4 but not TLR2 plays a role in AP. LFA-1 …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… directed inflammation. Genetic ablation of SAA receptor toll-like receptor 2 (TLR2) or the TLR signaling adaptor MyD88 reversed these microenvironmental changes in the liver. Notably, loss of STAT3 in hepatocytes or genetic ablation of SAA also induced remodeling of the primary tumor immune …
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The evolution of immune genes in tsetse flies (Glossina) and insights into tsetse-symbiont-trypanosome interactions
… genes: attacin-A (AttA), Defensin (Def) and Toll-like receptor 2 (TLR2), in relation to symbionts and parasitic interactions. This could in turn lay the foundations for genetic control methods The successful identification of novel attacin orthologues confirmed the previous descriptions of …
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Influence of dietary interventions on the immune system: an investigation of the impact of omega-3 fatty acids, dietary fermentable materials and high energy diets
… cells (mDC) and ex vivo responsiveness to a Toll-like receptor 2 (TLR2) agonist, while serum IL-10 concentrations decreased. A rat trial was designed to examine effects of a HE diet supplemented with varied DFM (7% wheat bran, oat bran, resistant starch type II, or fructooligosaccharide …
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Exploring the Effects of Adjuvant Selection on a Novel Polyvalent Staphylococcus aureus Vaccine
… to severe and potentially lethal conditions like sepsis. The emergence of multi-drug-resistant strains and the subsequent reduction in effective antibiotic options underscore the necessity for alternative treatments, such as vaccines. This project explored the optimisation of a novel …
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The Role of Bacterial Amyloids In Regulating Gastrointestinal Homeostasis
… are the most studied amyloids to date. Curli-like fibers are also produced by members of the predominant phyla found in the host gastrointestinal microbiota in environmental biofilms. Curli fibers are the predominant microbial-associated molecular pattern (MAMP) on enteric bacteria recognized …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… cells infiltration, I focused on the toll-like receptor (TLR)in ET-1 induced ischemic demyelinating lesion because TLRs are main mediator of postischemic inflammatory responses. There was a significantly increaseof TLR2 in the ET-1 induced ischemic white matter lesion. Increased …
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DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION
… with and modulate the activity of various immunoreceptors, such as pattern recognition receptors (PRRs) and Ig receptors. MS4A4A is selectively expressed by macrophages, and its expression is upregulated upon treatment with Interleukin-4 (IL-4) and glucocorticoids (Dexamethasone, Dex). However, …
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Effect of Advanced Age on the Innate Immune Response to Cutaneous Wound Infection
… of cutaneous antimicrobial peptides and aberrant toll-like receptor 2 (TLR2)</p> <p>expression and/or signaling. However, the effect of age on these specific alterations in the innate response has not been well described in a model of cutaneous wound infection. Thus, we hypothesized that advanced …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… considered to play roles in the pathogenesis. Toll-like receptors (TLRs) are involved in the initiation of innate immune response in several immune mediated inflammatory disease including BD by sensing the various microorganisms and triggering the signalling pathways, causing release of …
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Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins
… pattern recognition complex comprised of Toll-like receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is …
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Formation and Pathogenicity of Cytotoxic Curli Intermediates
… (PAMP) by their ability to activate numerous receptors in immune cells. The host immune response to curli complexes has been elucidated in our lab. First, binding to Toll-like receptor-2 (TLR2) begins with recognition of the conserved cross-β sheet secondary structure. Mutations disrupting …