Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"Toll-like receptor"”.
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TOLL-LIKE RECEPTOR EXPRESSION AND FUNCTION
… yet little is known about the role of toll-like receptors (TLR) which, upon activation, stimulate inflammation. The objective of this research was to determine: (1) baseline expression of TLRs in ocular surface cells, if TLR activation or products thereof (antimicrobial peptides, AMPs) …
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Innate immune recognition by human toll-like receptor 10 and other members of the toll-like receptor 2 subfamily
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2011-05-25T14:42:13Z Item is restricted until 2013-05-25T14:41:28Z
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Characterizing the function of human toll-like receptor 10
Toll-like Receptors (TLRs) are important constituents of the immune response, capable of both protecting the host from danger and inciting harm from within. In this Thesis, I present evidence that the last human orphan toll-like receptor, TLR10, has a unique function that differs from its other …
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Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension
… regimens. Very recently, role of toll-like receptors (TLRs), particularly TLR4 in pathogenesis of several inflammatory conditions including cardiovascular diseases are becoming evident. However, the functional im-portance of the brain TLR4 and its interaction with other molecules …
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MAPPIT analysis of the early events in Toll-Like receptor signalling
… van T and B lymphocyten die antigen-specifieke receptoren expresseren. Door deze clonale selectie en expansie is de adaptieve respons pas volledig operationeel drie tot vijf dagen na infectie. De aangeboren respons daarentegen vormt de eerstelijnsdefensie tegen pathogenen en is daarom essentieel …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… unrecognized functions for this innate immune receptor.</p>
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Investigation of toll-like receptor tolerance in the regulation of inflammation
… of noxious stimuli by pathogen recognition receptor families including Toll-like receptors results in the expression of hundreds of genes that encode cytokines, chemokines, antimicrobials and regulators of inflammation. Regulation of TLR activation responses is controlled by TLR tolerance …
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Defining the role of toll-like receptor 10 in immune signaling
Toll-like Receptors (TLRs) represent a class of pattern recognition receptors that function to recognize invading microbes and initiate pro-inflammatory responses. TLR10 is the only remaining orphan member of the human TLR family. Given the established role of TLR signaling in both the innate and …
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Regulatory Mechanisms Controlling Expression of the Toll-Like Receptor 2 Subfamily
… the post-translational localization of the receptor. In chapter five, I will summarize these findings and discuss the potential implications.
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… study designed to determine the plausibility of toll-like receptor agonists as an immunotherapeutic for canine osteosarcoma. From a comparative and translational perspective, the long-term goals of this research include not only the treatment of canine osteosarcoma, but also human osteosarcoma, …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… microenvironmental factors acting via a range of receptors, including Toll-like receptors (TLR). CD180/RP105 is a membrane-associated orphan receptor that belongs to the TLR family, is expressed by professional antigen-presenting cells, and drives normal B-cell activation and proliferation. We …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… of the central nervous system. Activation of Toll-like receptor 4 (TLR4), the primary transducers of innate immune system, is critical in microglial functions. Especially, activation of microglia by lipopolysaccharide (LPS), a ligand for TLR4, has been extensively studied. It was previously …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… evidence suggests that pattern recognition receptors of the innate immune system such as the toll-like receptors (TLRs) are involved. In the present study, we tested the central hypothesis that TLR4 is the link between reactive oxygen/nitrogen species (RONS), oxidative stress and …
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Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
Toll-like receptors (TLRs)-7/-8 are among pathogen recognition receptors (PRRs) present in the endosomal compartment that are activated by viral single-stranded RNA (ssRNA) as well as synthetic small molecules. TLR7/8 agonists hold promise as potential vaccine adjuvants, since they directly …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… the recognition of potentially harmful stimuli, Toll-like receptors (TLRs) initiate the innate immune response and induce the expression of hundreds of immune and pro-inflammatory genes. TLRs are critical in mounting a defence against invading pathogens however, strict control of TLR signalling …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. There have been reported that keratinocyte TLRs represent the first barrier against exogenous pathogens in human skin. Recently, it was reported that melanocytes not only function melanin synthesis …
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Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins
… pattern recognition complex comprised of Toll-like receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
… in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… to stimulate sterile inflammatory responses via Toll-like receptors (TLRs) and other pattern recognition receptors. The work in this thesis explored the contribution of cellular damage molecules in cell lysate and TLR signalling in macrophage responses to a range of non-resorbable polymers, …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control activation and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 …
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