Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Toll-interacting protein"”.
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external …
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… and are critical for pathogen clearance. Toll-interacting protein (Tollip) is an intracellular mediator of several immune mechanisms. Tollip negatively regulates TLR activation, and acts as a mediator of autophagy and endosomal transport. These mechanisms are involved in processes such …
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Ubiquitin Modulates Tollip's PtdIns(3)P Binding and Dissociates the Dimeric State of C-Terminal Cue Domain
… controlled post-translational modification of proteins, in which proteins are conjugated either with monoubiquitin or polyubiquitin chains. Ubiquitin modifications on target proteins are recognized by ubiquitin-binding domains, which are found in several effector proteins. In this study, we …
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Scanning Probe Microscopy Study of Molecular Nanostructures on 2D Materials
… report a liquid-cell AFM study on the endosomal protein sorting process on the biological lipid membrane. The sorting mechanism relies on complex forming between Tom1 and the cargo sorting protein, Toll interacting protein (Tollip). The induced conformational change in Tollip triggers its …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… for the development of subsequent infection. Tolllike receptors (TLRs) are a family of transmembrane receptors of the innate immune system that recognize pathogen-associated molecular patterns. The role of nasal colonisation of S. aureus has started to receive more attention. In spite of this, …