Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Tolerogenic dendritic cells"”.
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The interactions of tolerogenic dendritic cells, induced regulatory T cells and antigen-specific IgG1-secreting plasma cells in asthma
… with allergen-presenting IL-10-differentiated dendritic cells (DC) (DC10) leads to progressive and long-lasting full-spectrum asthma tolerance. However, little has been done in investigating a role for antigen-specific B cells in DC10-induced tolerance. In this study, we characterized the …
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Biological effects of synthetic biomolecules that may either mimic or antagonise the function of hCG in the development of cancer and autoimmune disease
… It achieves this by expanding immunoregulatory cells such as tolerogenic dendritic cells, regulatory T cells (Tregs), and regulatory B cells (Bregs). Interestingly, hCG is also secreted by certain tumours, helping them evade immune detection by creating a tolerogenic environment. This project …
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NAD+-DEPENDENT SIRT1 REPROGRAMS CD11C+ DENDRITIC CELLS AND CD4+ T CELLS TO CONTROL IMMUNE POLARITY DURING SEPSIS
… our model, SIRT1 activation acts through CD11c+ tolerogenic dendritic cells and their support of TGFβ and IL-10 secretions from CD4+ TReg cells as contributors to sepsis immunosuppression. That SIRT1 drives this innate and adaptive immune link is supported by the ability of SIRT1-specific …
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Immunomodulatory biomaterials to promote early transplant integration and wound healing
… pro-regenerative subsets of immune cells that work to enhance tissue regeneration and alloimmunity by dampening immune activation and cytokine production of factors involved in pathologic inflammation and rejection. We developed a hydrogel-based biomaterial system to deliver …
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Phosphatidylserine-Based Nanoparticles For Tolerance Induction Towards Therapeutic Proteins
… The exposure of PS on the surface of apoptotic cells functions as an “eat me” signal that initiates macrophage recognition, uptake, and removal of the apoptotic debris. The apoptotic process is an immunologically silent event, as these apoptotic cells are cleared without activation of the immune …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
IL-10-treated tolerogenic dendritic cells (DC10) have been used as a powerful tool for the treatment of experimental asthmatic responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA …