Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Tolerance-Induction"”.
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Phosphatidylserine-Based Nanoparticles For Tolerance Induction Towards Therapeutic Proteins
… removal of cell debris in order to maintain tolerance to self-proteins by immunosuppressive mechanisms and tissue homeostasis. The key function of PS exposure in apoptosis could be exploited for therapeutic implications, such as mitigation of immunogenicity towards therapeutic proteins. The …
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Alergia alimentar - temporalidade X antigenicidade
INTRODUCTION: Mechanisms involved in the induction of oral tolerance or systemic immunization through the oral rout are still not completely clear. In our previous studies we have shown that when normal mice eat peanuts they become tolerant, and do not develop gut alterations. However, if they are …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… was also implicated in promoting effective induction of adaptive immune responses in the LN as evidenced by abrogated T cell proliferation. An important component of both peripheral tolerance induction and initiation of adaptive immune responses is CCR7-dependent migration of antigen-loaded …
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Visualizing Dendritic Cells In Vivo
… the physiological role of dendritic cells in tolerance and immunity; this was achieved by intravital microscopy of fluorescently-labeled DCs and lymphocytes in the inguinal lymph nodes. We generated mice that specifically expressed EYFP in their dendritic cells and observed their behavior in …
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Overcoming skin rejection in composite tissue allotransplantation
… of chronic systemic immunosuppression, through tolerance induction, and site specific therapy. Previous experience in organ and composite tissue allotransplantation models are analysed to develop the hypothesis that high-level chimeras are tolerant to vascularised skin allotransplants. In utero …
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Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
… the goal of inducing antigen-specific T cell tolerance, the current study employed immunoglobulin Fc engineering to develop a novel platform for the delivery of peptide epitopes as Fc-peptide fusions with different dynamic properties. Using very low doses of these engineered antigens to avoid …
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Intestinal delivery of heterologous peptides with lactobacilli
… autoantigen is a promising method to induce oral tolerance in autoimmune diseases, such as multiple sclerosis. Multiple sclerosis (MS) is a complex disorder of the central nervous system. MS is caused by destruction of several brain antigens in myelin. In order to increase the efficiency of oral …
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Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction
… at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest in the case of acute graft-versus-host disease (GvHD), a common complication post …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
… pathogenic cells do escape thymic, or central, tolerance. Thus, a population of suppressor cells termed regulatory T cells (Treg cells) co-evolved in order to keep these self-reactive escapees in check. Treg cells that develop in the thymus as part of central tolerance induction are a critical …
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Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
… the immune system plays an important role in the tolerance induction to self-antigens both in the intestinal mucosa and at the systemic level. The MRL/lpr mouse model exhibits lupus-like symptoms early in life due to multiple SLE susceptible loci of the MRL background, plus the Faslpr mutation …
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The role of B cells in the amplification and in the regulation of transplant rejection.
… are contributing to<br/>transplantation tolerance. The aims of this project are: i) to investigate whether<br/>T2-MZP can transfer transplantation tolerance; ii) to analyse whether the<br/>expression of Galectin-1 (Gal-1), known to be a functional molecule for Tregs, is<br/>necessary for …
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THE ROLE OF DENDRITIC CELLS IN GRAFT REJECTION
Induction of acquired immunological tolerance is the ultimate goal in transplantation. So far the acceptance of a mismatched graft is achieved through immunosuppression that requires long-term treatment and a variety of methods have been explored to prevent rejection and achieve transplant …
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Zeitliche Analyse der histomorphologischen und durchflußzytometrischen Charakteristika der chronischen Abstoßung nach experimenteller Dünndarm-Transplantation
Die Monate nach Transplantation auftretende Abstoßung ist ein Haupthindernis für eine erfogreiche Transplantat-Langzeitfunktion des Dünndarms. Ursache ist das hohe Immunitätspotential dieses Organes. Ziel dieser Arbeit war es, sowohl die histomorphologischen Zeichen der chronischen Abstoßung, als …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A breakdown in such tolerance can result in the development of a variety of autoimmune diseases including rheumatoid arthritis, Type 1 diabetes, inflammatory bowel disease and coeliac disease. …