Global ETD Search
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Showing 1 to 2 of 2 for “"Tolcapone"”.
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Illness Impact and Adjustment to Parkinson's Disease: Before and After Treatment with Tolcapone
… and adjustment) was improved by treatment with tolcapone in persons with Parkinson's disease. This study was done in parallel with a double-blind placebo controlled study of the efficacy and safety of tolcapone. Quality of life was measured by the Sickness Impact Profile (SIP) and adjustment to …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… of 8.4 μM and 12.5 μM respectively. Moreover, tolcapone inhibits hCIC with an IC50 of 5 μM, three times more potent than the canonical inhibitor benzene tricarboxylic acid. Moreover, detailed understanding of the transport processes underpinning the translocation of substrates of other carriers …