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Showing 1 to 16 of 16 for “"Tocotrienol"”.
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Impact of delta-tocotrienol on human melanoma cell proliferation
… nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, pancreas, and prostate tumor cells. Dietary …
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Preparation and evaluation of tumour-targeted delivery systems for tocotrienol
Tocotrienol, a group of compounds present in vitamin E, has gained much attention in recent years for its tumour suppressive properties on cancer cells. However, its therapeutic potential was hampered by the limited ability to reach tumours specifically after intravenous administration. In this …
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Intervention of non-small cell line cancer oncogenic pathways with delta-tocotrienol
… Notch-1 gene. Our data demonstrated that delta-tocotrienol could inhibit NSCLC cells proliferation, invasion and induce apoptosis by down-regulation of the Notch-1 signaling pathway. Using microRNA microarray and microRNA transfection, our findings further suggest that delta-tocotrienol is a …
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Extraction and Purification of Gamma-Tocotrienol from Rice Bran Oil Deodorizer Distillate
… tocopherols (T); alpha-, beta-, gamma- and delta-tocotrienols (T3)) make up the vitamin E family of antioxidants. Tocols have many health benefits. Gamma-T3 has been shown to protect against harmful radiation effects in mice. During rice bran oil refining up to 90% of tocols in rice bran are lost …
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Optimisation of the anti-cancer efficacy of various tocotrienol isomers by entrapment in tumour-targeted vesicles
Tocotrienol is a group of four isomers, found in nature as part of vitamin E. Although known for its anti-cancer activity, its therapeutic use is hampered by its limited ability to specifically reach tumours after intravenous administration. Recently, we demonstrated that tocotrienol-rich fraction …
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The impact of degree of milling on the contents of rice bran lipids and gamma-tocotrienol
… the impact of milling on total lipids and γ-tocotrienol concentrations in rice brans of Cheniere and Francis varieties. The brown rice obtained after dehulling was milled to 4%, 6%, 8% and 9% milling degrees. Total lipids were analyzed using AACC method and γ-tocotrienol was quantified by …
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Der Metabolismus der Tocopherole und Tocotrienole
… für 4 Tocopherole (α, β, γ und δ) sowie 4 Tocotrienole (α, β, γ und δ), die als gemeinsames Merkmal ein Chromanolringsystem sowie eine gesättigte (Tocopherole) bzw. ungesättigte (Tocotrienole) Seitenkette aufweisen. Neben ihrer antioxidativen Wirkung (Schutz von Membranen vor …
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Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis
… hardening. Grape seed polyphenol (GSP) and d-tocotrienol (d-T3) may have benefits in reducing NASH. We observed the effects of dietary GSP & d-T3 (separated and combined: GSP - 2%; d-T3 - 0.05%) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks. Hepatic cholesterol, triglycerides, …
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Isolierung und Charakterisierung der gamma-Tocopherolmeth yltransferase
Bei den Tocopherolen und Tocotrienolen handelt es sich um niedermolekulare Antioxidantien, die in der Lage sind, Singulett-Sauerstoff direkt aus der Membranumgebung zu entfernen, indem sie als Radikalfänger fungieren. In der Medizin wird Vitamin E gegen Krankheiten wie Krebs und Alzheimer …
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Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions
… pathway is identical for all tocopherols and tocotrienols, there is a marked difference in the amount of the release of metabolites from the individual vitamin E forms in cell culture as well as in experimental animals and in humans. Recent findings not only proposed an CYP3A4-mediated …
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The Synthesis and Reactivity of Vitamin E Quinones
… The synthesis of α-tocopherol quinone and α-tocotrienol quinone produced the target compounds in 80% yield. The oxidations of the other tocol isoforms yielded para-tocol quinones (29-45% yield) and ortho-tocol quinones (20-35% yield). The rate of reaction of the tocopheryl quinones with NAC …
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The <em>In Vitro</em> Cellular Uptake and Physiochemical Properties of Tocotrienols.
<p>This research, focusing mainly on tocotrienols, includes two parts. The first part concerns the uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E.</p><p>In the cellular study our results suggested that position 5 …
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Anticancer Effects of Vitamin E Forms and Their Long-chain Metabolites via Modulation of Sphingolipid Metabolism
… (γT), delta-tocopherol (δT), and gamma-tocotrienol (γTE) exhibited potent anticancer activities in various types of cancer cells. But molecular mechanisms underlying anticancer actions of γTE are not completely understood. 13’-carboxychromanols (13’-COOHs), major fecal excreted …
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Multifaceted Nutritional Intervention In Hemodialysis Patients
… several nutrients namely omega-3 and vitamin E tocotrienols on nutritional and oxidative indicators, inflammatory markers and lipid profiles in a cohort of chronic HD patients.</p> <p> The objective of the first study was to evaluate the impact of omega-3 plus liquid protein supplement on serum …
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Vom Antioxidanz zum Genregulator : transkriptionelle Regulation von Phase I- und Phase II-Enzymen durch Vitamin E und antioxidative sekundäre Pflanzeninhaltsstoffe
… Entgegen der in vitro-Situation hatte gamma-Tocotrienol in vivo einen nur kaum nachweisbaren Effekt auf die Expression der Cyp3a11 mRNA, induzierte aber die Expression der alpha-TTP mRNA. Es konnte gezeigt werden, dass Vitamin E und sekundäre Pflanzeninhaltsstoffe Phase I- und Phase II-Enzyme …
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Studies on cholesterol metabolism in prostate cancer cells
… homeostasis should be targeted in PCa, we used tocotrienols, a form of vitamin E previously found to selectively target PCa cells in vitro. We found that tocotrienols degrade SREBP-2 by a novel mechanism. In turn, we found that SREBP-2 activity determined resistance to tocotrienols in cell …