Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tlr5"”.
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Gut Microbiota Regulation of SLE Pathogenesis
… bacterial flagellin and Toll-Like Receptor 5 (TLR5) on immune cells. These interactions garnered substantial attention due to their potential implications in the pathogenesis of SLE. We synthesized existing research, providing valuable insights into the complex interplay between SLE and the …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… cancer cells. Results: Treatment with TLR4 and TLR5 ligands, but not ligands for TLR2 and TLR9 increased the expression of Fas and FasL in intestinal cancer cells in vitro. Consistent with this, expression of Fas and FasL was reduced in the distal colon tissue from germ-free (GF), TLR4 and TLR5 …
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Bluttest statt Mammografie-Sreening?
… (FEZF2), cg16304215 (OTP) und cg23035715 (TLR5). Diese Marker wurden ursprünglich als hochsensitive cfDNA-Methylierungsmarker beschrieben und hinsichtlich ihrer diagnostischen Relevanz untersucht. Dabei erfolgte ein Vergleich intragener und promotorspezifischer Methylierungsmuster mit …
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p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… real-time PCR (qPCR), seven (INPP5D, TLR5, KRT15, EPHA2, GDNF, NOTCH1, SOX9) were confirmed to be novel direct targets of p53, based on responses in stable MCF7 clone cells silenced for p53, or cooperative targets of p53 and ER. Based on exposure to 5-fuorouracil (another genotoxic …
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Immunomodulatory effects of LL-37 in the epithelia
… keratinocytes in response to IL-1β and the TLR5 agonist flagellin, and synergistically increased IL-8 production by bronchial epithelial cells in response to IL-1β, flagellin, and the TLR2/1 agonist PAM3CSK4. Treatment of bronchial epithelial cells with LL-37 and the TLR3 agonist poly(I:C) …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… hyperflagellated, to avoid Toll-like receptor 5 (TLR5)-mediated recognition. The <i>N</i>-alpha mercaptoamide dipeptide inhibitor, ME-YV, was included in these experiments and shown to prevent ZapA-mediated effects, validating the efficacy of ZapA as a target for the action of anti-virulence …
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… Similarly to TLR4, IL-27 treatment also enhances TLR5 expression in human monocytes and macrophages, inducing cytokine production in response to TLR agonists LPS and flagellin or S. enterica infection. IL-27 also increases LPS/ATP-mediated NLRP3 inflammasome activation and IL-1β production in …
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
<p>Pre-exposure of the cornea to TLR5 ligand flagellin induces profound mucosal innate protection against infections by reprogramming gene expression. This study explored the flagellin-induced modifications of transcription factor expression and function, specifically of IRF1 and ATF3 in corneal …
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TOLL-LIKE RECEPTOR EXPRESSION AND FUNCTION
… had no effect on TLR expression. TLR4 and TLR5 were upregulated in response to desiccation. TLR9 expression was downregulated in response to HOS, desiccation and in dry eye subjects. (3) EDE modulated TLR mRNA and protein expression by the ocular surface and lacrimal gland, compromised …