Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Tks5"”.
-
Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
Tks5 is a Src tyrosine kinase substrate and scaffolding protein for specialized cytoskeletal structures called podosomes/invadopodia. My doctoral thesis has focused on how Tks5 regulates the formation of these related structures and their impact on the invasive phenotype of cells. The podosomes of …
-
Implication des protéines adaptatrices Tks4 et Tks5 dans la dégradation du cartilage articulaire par les synoviocytes dans la polyarthrite rhumatoïde
… Tyrosine Kinase Substrate 4 et 5 (Tks4,Tks5) sont essentielles à la formation de l’invadosome ainsi qu’à sa maturation menant à la dégradation de la matrice extracellulaire. L’objectif de cette étude est de déterminer si l’activation de Src chez les A-FLS et les RA-FLS médie la formation …
-
Transcriptional regulation of metastatic progression in lung adenocarcinoma
… on an isoform switch of the adaptor protein Tks5. The Tks5long isoform, which is upregulated in metastatic cells, is capable of localizing to the cell membrane and activating invadopodia formation. In contrast, the Tks5short isoform, which is transcribed from a promoter independent of …