Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Tissue-type plasminogen activator"”.
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor-1 (PAI-1) is a serpin protein whose function is to inhibit tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and hence, fibrinolysis. This inhibition leads to decreased plasminogen to plasmin conversion, which results in …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor (PAI-1) is a member of the serine protease inhibitor (serpin) family of proteins, which inhibits certain serine proteases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and thus is a primary regulator of …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. PAI-1 is involved in the regulation of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type …
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates fibrinolysis as well as the development of …
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Role of Plasminogen and Urokinase-Type Plasminogen Activator in Cardiac Mesenchymal Cell Migration In Vitro
Studies show that urokinase-type plasminogen activator (uPA) conversion of plasminogen into plasmin is an important mediator of cell migration. In the developing chick heart, uPA has been implicated as a mediator of atrioventricular (AV) cushion cell migration, however the role of the …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have required caution when used. In this context, several approaches are required …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
… lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis to circumvent prolongation mediated by activated TAFI (TAFIa). Therefore, the effects of TAFIa on Lys-Pg activation and Lys-plasmin (Lys-Pn) inhibition by antiplasmin (AP) were …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… the expression of mRNA and protein for the tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA) and their inhibitor PAI-1 was measured in granulosa cells. uPA and PAI-1 mRNAs peaked 12 hours and 36 hours after hCG administration respectively. tPA mRNA …
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An experimental study of human melanoma cells cutured in vitro
… other melanomas studied, these cells released a plasminogen activator that was chemically and immunologically identical to tissue activator. One of the lines proved to be an exception to this general rule in that it synthesized urokinase-type enzyme. Unlike most other human cells cultured in …
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Effect of dietary fibre on selected haemostatic variables and C-reactive protein
… include, amongst others, the haemostatic factors tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), factor VII (FVII) and fibrinogen and more recently, C-reactive protein (CRP), a sensitive marker of inflammation. Epidemiological studies have demonstrated an …