Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Tissue-mimicking"”.
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Production and Characterisation of Tissue-mimicking Collagen Scaffolds for Cardiac Tissue Engineering
The ideal scaffold for tissue engineering provides an architecture similar to natural tissue. For cardiac tissue repair, this three dimensional environment can be modelled on the myocardial extracellular matrix (ECM). To approximate the material composition of the ECM, collagen type I can be used, …
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
The design of an in vitro model of the tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on …
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Creation of brain tissue-mimicking material and multi-material gradient 3D printer for magnetic resonance elastography phantom
… resonance elastography (MRE) is a non-invasive tissue imaging method that measures shear stiffness. While MRE has many benefits, it is not currently used clinically for scanning the human brain, mainly because it has not been validated with independent mechanical property testing methods. This …
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Assessing the Biomechanical Properties of Cornea using Optical Coherence Elastography
… growing demand for noninvasive high-resolution tissue characterization with improved diagnosis and treatment of ocular diseases. The research work was based on optical coherence tomography (OCT), a rapid, high-resolution, three-dimensional imaging modality that enables noninvasive depth-resolved …
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Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging
… resolved detector array technology in vitro, in tissue mimicking phantoms, in an ex vivo oesophageal model and in vivo in a mouse model. A hyperspectral linescan sensor was first integrated in a wide-field near-infrared reflectance based imaging set-up to assess the suitability of spectrally …
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Quantitative assessment of elasticity properties of skin using surface acoustic wave (SAW) method
Mechanical properties are important tissue parameters of skin that are useful for understanding skin patho-physiology, and aiding disease diagnosis and treatment. They are indicators of functional changes and pathological variations in the micro-structure. <br/><br/>This research thesis studies the …
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Dynamics and rheology of soft phase-change materials
… and gelatin), pharmaceutical products (e.g., tissue mimicking phantoms and encapsulating agents), cosmetics (e.g., foundations and lipsticks), and in the oil and gas industry, where formation of paraffin waxes and clathrate hydrates represent major issues for upstream production and flow …
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Development of a Colonoscopy Simulator for the Evaluation of Colonoscopy Devices
… literature was reviewed and possible tissue mimicking materials were selected. The suitability of the selected materials was evaluated by testing the frictional and elastic properties of the materials and subsequently comparing the results to those of colon tissue. PVA cryogel was …
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Real-time beam visualization and therapy planning for focused ultrasound therapies using a diagnostic imaging array
… therapeutic effects in localized regions of tissue through thermal elevations or mechanical stresses caused by an ultrasound wave. Although FUS therapy is effective at treating many different diseases, FUS therapy can be expensive and time-consuming because the treatment must be planned and …
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Validation of photoacoustic imaging biomarkers in cancer biology
… general design considerations for preparation of tissue-mimicking phantoms are discussed to guide the development of a stable phantom material in PAI. Acoustic and optical material characterisation systems are then established and validated to enable thorough characterisation of phantom materials. …
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Deep structure ultrasound imaging using fundamental and third harmonic coded excitation techniques
… small anechoic targets (cysts) deep within a tissue-mimicking phantom. Golay coding with 1, 3 REC compounding was able to detect 3 mm and 2 mm diameter anechoic targets deep within the tissue-mimicking phantom while chirp 1, 3 compounding and conventional pulsing could only detect 4 mm …
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Real time motion tracking in image guided focused ultrasound intervention
… for less- or non-invasively destroying unhealthy tissue deep inside the body, without damage to the skin or surrounding tissues. The procedure has been performed under both diagnostic ultrasound and MRI guidance. Treating cancers and metastases in the liver that are unresectable is a potential …
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Engineering Considerations for Treatment of Prosthetic Joint Infections Using Alternating Magnetic Fields (AMF)
… temperatures of 65-80°C within 10-14 seconds. A tissue-mimicking phantom of the sheep leg was developed to evaluate heating with the system and to compare these results with numerical simulations. Single and intermittent AMF exposures of a tissue-mimicking phantom agreed with numerical …
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Propagation of High Intensity Focused Ultrasound through a Patient-specific Ribcage Model
… at the ribs may lead to surrounding soft tissue damage due to the bones properties of absorption and reflection to the ultrasound wave. Current research has not involved the physical human anatomical structures into the experimental study of the HIFU treatment through the ribcage. …
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Real-time membrane puncture detection using force sensors for micro-injections in phantoms
… closed-loop force feedback to compensate for tissue deformation during micro-interventions. Force sensors can detect puncture events as the needle penetrates tissue membranes, thereby reducing damage to surrounding tissues by preventing the needle from overshooting its target. Changing the …
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Focusing Light Inside Scattering Media with Optical Phase Conjugation
<p>In scattering media such as biological tissue, the heterogeneous refractive index distribution causes light to scatter, which makes the media look opaque and prevents us from focusing light beyond ~1 mm deep inside the media to achieve optical imaging and manipulation. Hence, the ability to …
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Development of x-ray luminescence detection system and characterization of x-ray irradiated quantum dots for image-guided x-ray photodynamic therapy
… scattering medium was fabricated to reproduce tissue-mimicking optical property in XL computed tomography (XLCT) study.
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Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window
… the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow surrounding tissue to cool down. Large contiguous lesions are produced by raster-scanning …
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Combined ultrasound, photoacoustic and elasticity microscope for tissue engineers
Tissue engineering is an interdisciplinary field that combines various aspects of engineering and life sciences and aims to develop biological substitutes to restore, repair or maintain tissue function. Currently, the ability to have quantitative functional assays of engineered tissues is limited …
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