Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Tissue transglutaminase"”.
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The interaction of angiocidin and tissue transglutaminase
… and cell-extracellular matrix interactions. Tissue transglutaminase is ubiquitously expressed in various tissue types, occurs in both an intracellular and extracellular form, and is highly expressed in endothelial cells and smooth muscle cells in the vasculature. Tissue transglutaminase is …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
Tissue transglutaminase (tTG) is a protein-crosslinking enzyme whose expression is up-regulated in several human cancers. Here I show that tTG is a key participant in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF …
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Effects of organophosphates on neural and purified liver tissue transglutaminase
Transglutaminase 2 (TGase 2) is a multifunctional calcium dependent enzyme that catalyzes protein modifications. TGase 2 is essential in neuronal cell differentiation and it has been reported that certain organophosphates are able to inhibit this process, and the organophosphate phenyl saligenin …
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Significance of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer
… them for improved clinical outcomes.</p> <p>Tissue transglutaminase (TG2) is a multifunctional pro-inflammatory protein involved in diverse physiological processes such as inflammation, tissue repair, and wound healing. Its expression is also implicated in pathological conditions such as …
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Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
… Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal metastasis. TG2 is a multifunctional protein which catalyzes Ca2+-dependent cross-linking of proteins. The purpose of this study was to explore the mechanism by which …
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Design, Synthesis and Evaluation of Covalent Inhibitors for Tissue Transglutaminase and Factor XIIIa
Transglutaminases are a family of enzymes expressed in various tissues of our body. Some are expressed ubiquitously while others are specific to a tissue. Their primary catalytic activity is to crosslink substrates via an isopeptidic bond. The work described in this thesis focuses on two of these …
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The importance of the tissue transglutaminase-fibronectin heterocomplex in the RGD-independent cell adhesion and fibronectin matrix deposition
Tissue transglutaminase (TG2) has been reported as a wound response protein. Once over-expressed by cells under stress such as during wound healing or following tissue damage, TG2 can be secreted and deposited into extracellular matrix, where it forms a heterocomplex (TG-FN) with the abundant …
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Cell attachment to Zein surfaces
… in various biomedical applications, such as tissue engineering and circulating cancer cell retrieval. Understanding the mechanism of cell-substrate interaction is pivotal for exploiting the potential of those materials. Adhesion of cells to substrate surfaces is often mediated by tissue …
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Celiac Test Assay Comparison: Bio-Rad Autoimmune EIA Anti-Tissue Transglutaminase (tTG) IgA and IgG Tests on the Inova Quanta-Lyser 240 vs. BioPlex 2200 Celiac IgA and IgG Kits for Use at a Large Reference Laboratory
<p>As awareness of Celiac disease grows, testing services offered by clinical laboratories must expand accordingly. Testing needs at large reference laboratories are especially impacted by this change due to their coverage of broad geographic range and diverse patient populations. For this reason, …
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Transglutaminase in the life and death of the pancreatic β-cell
Tissue transglutaminase (TG2) is a ubiquitous enzyme that catalyses both the Ca2+-dependent formation of protein cross-links via intermolecular isopeptide bonds, and the Ca2+-independent hydrolysis of GTP. The multifunctional nature of the TG2 protein has been reported in numerous intracellular …
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Social and Behavioral Characteristics of Individuals with Celiac Disease
… were tested for immunoglobulin A (IgA) tissue transglutaminase antibodies and, if findings were abnormal, also for IgA endomysial antibodies. Weight and waist circumference were collected. Information about demographics, food security, weight status, and consumer behaviors were obtained …
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Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype
… and the GTP-binding protein/crosslinking enzyme tissue transglutaminase (tTG), two proteins suspected to have key roles in tumor initiation and the development of the malignant state, in glioma stem cells (GSCs). Additionally, I examined the contributions of two isoforms of glutaminase (GLS), …
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Triggers of autoimmunity. Studies on gestational events.
… pregnancy was associated with development of tissue transglutaminase (tTG) autoantibodies or CD in the offspring. These aims have been summarized in four independent studies. Study population and Methods The Diabetes Prediction in Skåne (DiPiS) is a population based study where blood samples …
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Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
… (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. However, less is known …
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Multiscale Characterisation of Ice and Collagen: Physicochemical Development of Lyophilised Scaffolds for Tissue Engineering
… ideal pixel size to image porous structures for tissue engineering without loss of resolution or computational feasibility. Scaffolds were then fabricated using 33 different conditions as modifications to the standard production route. The modifications encompassed changes to concentrations, …
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Screening Detected Celiac Disease in Children
… conducted by using a serological marker, anti-tissue transglutaminase antibodies (tTG-IgA). The CD diagnosis was confirmed by a small intestinal biopsy using either a suction capsule or endoscopy according to local routine in the study sites. The clinical diagnostic procedure was reviewed by …