Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Tissue stiffness"”.
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Genome Variation Across Cancers Scales With Tissue Stiffness--An Invasion-Mutation Mechanism
… data reveals that cancers arising in stiff tissues, such as lung and skin, exhibit more than 30-fold higher mutation rates than those arising in soft tissues, like marrow and brain. This scaling relationship suggests a possible mechanical source of cancerous mutations. We hypothesize that …
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The Effects of Heat and Sports Massage on Resting Muscle and Connective Tissue Stiffness
… Heat on Resting Muscle and Connective Tissue Stiffness. Chairperson: Dr. Valerie Rich Introduction: Massage is promoted to enhance sports performance by increasing tissue extensibility, increasing circulation and decreasing pain from previous injury or strenuous competition. The use of …
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The Effects of Heat and Sports Massage on Resting Muscle and Connective Tissue Stiffness
… Heat on Resting Muscle and Connective Tissue Stiffness. Chairperson: Dr. Valerie Rich Introduction: Massage is promoted to enhance sports performance by increasing tissue extensibility, increasing circulation and decreasing pain from previous injury or strenuous competition. The use of …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
Aortic stiffness increases with hypertension and aging, and much of this increase has been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aortic stiffness, a reconstituted aortic …
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Mechanical characterisation of rodent spinal cord tissue in health, trauma and disease
Spinal cord tissue is amongst the softest tissues in the body. Studying its mechanical properties is important as many cell types in the spinal cord react to their mechanical environment. Injury and disease can change spinal cord tissue stiffness, and conversely, altered tissue stiffness can affect …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two different types of signals remains poorly understood. Here, I investigated how tissue …
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Physical Factors Regulating Human Trophoblast Invasion
… In this thesis, physical factors, specifically, tissue stiffness and oxygen are studied as regulators of trophoblast invasion. The mechanical environment is known to regulate cell fate and the migratory behaviour of cells. Despite invasion of EVT cells through decidual tissue rich in …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… not only axon pathfinding but also mechanical tissue properties. Tissue-specific downregulation of Piezo1 in either optic tract axons or in the surrounding neuroepithelia both resulted in optic pathway defects; suggesting that cell-autonomous and non-cell autonomous processes are …
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In vivo and in vitro guidance of developing neurons by mechanical cues
… Here, I have identified a role for tissue mechanics in embryonic axon guidance in vivo, using retinal ganglion cell (RGC) axon outgrowth in the developing Xenopus laevis optic tract (OT) as a model system. Using atomic force microscopy (AFM) to map brain stiffness in vivo, I found …
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Magnetically Actuated Microrobots for Tissue Elasticity Mapping in Colorectal Cancer Diagnosis
… Recent research highlights increased tumour stiffness due to cellular proliferation and extracellular matrix changes as a promising mechanical biomarker for early cancer detection. Magnetically actuated microrobots have recently emerged as versatile tools for medical applications. Their …
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Regional Mechanical Properties and Microstructure of Ovine Heart Chambers
<p>Mechanical properties of cardiac tissue play an important role in the normal heart function. As a baseline for understanding of physiology and pathophysiology of the heart, and for development and validation of new therapies, it is crucial to first understand the mechanical behavior of the …
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Investigating the Interplay between Inflammation and Matrix Stiffness: Evaluation of Cell Phenotype and Cytoplasmic Stiffness In Vitro
… that subsequently lead to an increase in tissue stiffness and changes to ECM architecture. Such changes to the mechanical properties of the cellular microenvironment affect the cytoskeletal arrangement, migration and adhesion of both the parenchymal cells, as well as immune response cells, …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
… poorly understood, I investigated the role of tissue stiffness in this signalling pathway using the optic pathway of the African clawed frog, Xenopus laevis, as a model system. Using atomic force microscopy, I found that, in vivo at early stages, the Xenopus optic tectum was soft and …
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The Effect of Limb Movement on the Lumbopelvic Region in People with Low Back Pain
… and movement tests potentially affected by limb tissue stiffness, but not during a movement test unaffected by limb tissue stiffness. In Chapter 3, we examine differences in lumbopelvic motion between people with and people without LBP during two active limb movement tests. We report that, …
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Elastic Characterization of <i>ex vivo</i> Human Prostate Tissue Using Vibration Optical Coherence Elastography and Second Harmonic Generation Microscopy
… coherence elastography (OCE) to quantify the tissue stiffness on a microscopic scale. A feasibility study of ten patients suspected with PCa was designed to scan TRUS guided biopsies with the vibration OCE. Meanwhile, the effect of fixatives on the tissue stiffness was studied with five …
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Mechanical Characteristics of Male Urethral Catheterization: Simulator and Cadaveric Donor Study
… Displacement-dependent effects resembling tissue stiffness appeared to dominate the force profile over rate-dependent effects such as viscous friction. In cadaveric studies, the average prostate region force was found to be higher than non-prostate region force. Average catheterization …
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A wearable blood pressure sensor using oscillometric photoplethysmography and micro accelerometers
… mechanisms of pressure propagation within the tissue, a comprehensive non-linear finite element model of the finger base is constructed and validated using a combination of magnetic resonance imaging and experimental tissue stiffness measurements.
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Finite Element Analysis on the skin properties affecting wound closure
… wound contraction forces, and subcutaneous tissue resistance are all varied. Two major conclusions can be drawn from these simulations. (1) When comparing rectangular, square, and circular wounds of the same initial wound size, rectangular wounds close fastest and circle wounds close …
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Fibulin-2 Stabilizes Tumor Extracellular Matrix and Drives Malignant Progression of Lung Adenocarcinoma
… dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein involved in ECM supra-molecular assembly. Fibulin-2 depletion in tumor cells decreased the intra-tumoral abundance of matrix …
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Development of an implantable sensor for continuous real-time long-term monitoring of soft tissue biomechanics
Measuring the mechanical properties of soft tissue can be an important method to detect pathology. Concerning the brain in particular, correlation between abnormal tissue stiffness and morbidity has been reported for Alzheimer's disease, Parkinson's disease and brain tumors, among others. On a more …
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