Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 160 for “"Tissue regeneration"”.
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Heparanoid hydrogels for cardiovascular tissue regeneration
Heparin (Hep) and heparan sulfate (HS) have been shown to possess anticoagulative properties, inhibit smooth muscle cell proliferation, moderate inflammation and control angiogenesis by stabilization and potentiation of growth factors (GF). These properties are potentially very useful for the …
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Drug eluting electrospun scaffolds for tissue regeneration
… healing response to electrospun scaffolds in tissue engineering is often limited by poor ingrowth due to insufficient porosity, thrombogenicity, lack of vascularisation and/or excessive inflammation. This study aimed at increasing structural porosity and incorporating/delivering …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… cell injection are still problematic. Myocardial Tissue Engineering (MTE) is a Regenerative Medicine approach, able to integrate cell therapy with the use of polymeric substrates (myocardial scaffolds or heart patches) that can reduce cell loss and potentially prevent remodeling and fibrotic …
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Alginate-based Hydrogels for Central Nervous System Tissue Regeneration
… transplantation, limiting treatment efficacy. Tissue engineering approaches aim to restore tissue functions combining principles of cell biology and engineering, using designed and tailored three-dimensional biomaterial scaffolds. In this study we tested alginate as candidate biomaterial for …
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STRUCTURALLY SUPPORTED CELL-LADEN SCAFFOLDS FOR BONE TISSUE REGENERATION
… there has been an increased focus on finding a tissue engineered solution. However, while great progress in this field has been achieved, researchers have yet to suitably combine the proper biological and structural environments needed to serve as a complete bone tissue substitute that is …
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Mechanical properties of collagen-based scaffolds for tissue regeneration
Collagen-glycosaminoglycan (CG) scaffolds for the regeneration of skin and nerve have previously been fabricated by freeze-drying a slurry containing a co-precipitate of collagen and glycosaminoglycan. Recently, mineralized collagen-glycosaminoglycan (MCG) scaffolds for bone regeneration have been …
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Creation of Ovalbumin Based Scaffolds for Bone Tissue Regeneration
… a viable alternative to synthetic materials for tissue engineering. Although many bio-based materials have been used, Ovalbumin (OA) has not yet been researched to create 3D structures that promote cellular responses. Micro-porous scaffolds are a promising construct for bone tissue regeneration; …
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
Normal tissue homeostasis as well as tissue regeneration and repair after damage rely on resident stem cells. Incomplete regeneration in mammals has been attributed to an insufficient number of stem cells and a rapid fibro/adipocytic infiltration after wounding. Excessive scar formation compromises …
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Bioinspired alterations of collagen-glycosaminoglycan scaffolds for tissue regeneration applications
… characterized by the development of granulation tissue (scar) which lacks the structural and functional properties of the native tissue's extracellular matrix (ECM). Scar formation has been linked to the presence of inflammation, as injuries in environments with little inflammation (e.g. fetal) …
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Transcriptional and post-transcriptional regulation in tissue regeneration and disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Physical analysis of collagen-GAG composite scaffolds for nucleus pulposus tissue regeneration
In this study biomaterial scaffolds for regeneration of nucleus pulposus were developed by freeze drying slurries with different proportions of collagen II (CII), chondroitin-6-sulfate (CS), and hyaluronic acid (HA). The scaffolds were analyzed using biochemical assays to determine final …
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A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex
… we are trying to address in this work is the regeneration of the pulp-dentin complex (PDC), specifically the interface. Endeavors in regenerating either pulp or dentin have been successful individually, but the interface region is the anatomical and physiologic hallmark of the PDC and has not …
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Prospective Clinical Study with New Materials for Tissue Regeneration: A Study in Humans
… bone, residual biomaterial, and connective tissue. Data were submitted to analyze the radiological mean differences in length, width, and density. Paired t-tests were deployed for the analysis of differences within each group between the baseline (preoperative) and the final (postoperative) …
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
Bone is currently the second most transplanted tissue, second only to blood. However, significant hurdles including graft supply and implant failure continue to plague researchers and clinicians. Currently, standard clinical procedures include autologous and allogeneic grafting. Autologous grafts …
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The Functional Roles of the Lin28/let-7 Axis in Tissue Regeneration and Cancer
… roles of Lin28 and let-7 in the context of tissue regeneration and liver cancer. Our first study led us to discover that Lin28 overexpression is both sufficient to initiate liver cancer and necessary for its maintenance and that its oncogenic effects are mediated in part through …
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Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… place to rapidly and effectively repair damaged tissues. The goal of this dissertation work was two-fold. First, this work sought to gain insights into the mediators of inflammatory-induced tissue injury using the protein tyrosine phosphatase PTP-PEST as a potential regulator of endothelial …
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Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
… to restore physiologic function to damaged tissue remains poorly understood. Here, I uncover the non-essential amino acid serine as a surprising regulator in this process. Utilizing dietary intervention and HFSC-specific loss-of-function studies, I demonstrate that under serine-depleted …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
… ability to maintain, regenerate and repair tissues throughout the lifetime of the organism. Whether parsimonious utilization of adult stem cells is necessary to preserve their long-term potential has not been fully explored. I investigated this issue using the adult murine hair follicle stem …
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MORPHOLOGICAL, MOLECULAR AND GENETICAL ASPECTS OF THE ORAL CAVITY IN COVID-19 DISEASE FOR DIAGNOSIS, SURVEILLANCE, AND TISSUE REGENERATION PURPOSES
… alterations occurring in the lingual tissues of COVID-19 subjects; (iii) investigate the genetic susceptibility to the infection; (iv) contribute to define the pathogenesis of the disease and (v) explore new methodologies such as the use of nanomaterials for regenerative purposes. …
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