Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Tissue morphology"”.
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Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
… complexity of the morphological phenotypes in tissue slides render manual quantification impractical. This work presents deep learning approaches to understand the basis and implications of ITH through the lens of tissue morphology. These approaches are applied to two cancer types clear-cell …
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The Effects of Chronic Nitrite Exposure on Tissue Morphology and Physiology in Xiphophorus couchianus
… the effects of chronic nitrite exposure on tissue physiology, morphology and oxidative stress in live-bearing female fish. We hypothesized that chronic nitrite exposure would lead to elevated levels of accumulated nitrite in tissues, altered morphology of tissues, and affect oxidative stress …
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Characterization of Andrenocortical Tissue Morphology, Histology, and Steroid Synthesis Among Finetooth (<i>Carcharhinus isodon</i>), Blacktip (<i>Carcharhinus limbatus</i>), Atlantic Sharpnose (<i>Rhizoprionodon terraenovae</i>), and Bonnethead (<i>Sphyrna tiburo</i>) Sharks
<p>Adrenocortical (interrenal) tissue is composed of steroidogenic cells that produce corticosteroids involved in the stress response and hydromineral balance. Previous research characterizing the elasmobranch interrenal suggests that the number of interrenal bodies that produce the single primary …
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Naturally Derived Scaffolds for Treatment of Volumetric Muscle Loss
… of function in skeletal muscle as a result of tissue loss. Herein, cell and growth factor loaded keratin hydrogels and Tissue Engineered Muscle Repair (TEMR) constructs consisting of cell seeded, cyclic stretched bladder acellular matrix (BAM), were investigated in VML injuries in which the …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… of mannan-rich natural formulations on broiler tissue morphology, mucin barrier integrity, digestive enzyme capacity, apoptotic and necroptotic cell death levels and the expression of inflammatory cytokines. Supplementation of diet with each mannan-rich fraction (MRF) increased villus height and …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
… barrier for tumorigenesis. I utilise intestinal tissue and generate various genetically modified 3-dimensional organoid models to study the role of APC in malignant transformation of the intestinal epithelia. I show that APC inactivation leads to alterations in tissue morphology. Intriguingly, my …
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Early diagnosis of cancer using light scattering spectroscopy
… developed for quantitative characterization of tissue morphology as well as in vivo detection and diagnosis of the diseases associated with alteration of normal tissue structure such as precancerous and early cancerous transformations in various epithelia. LSS employs a wavelength dependent …
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Development of a real time trimodal spectroscopy diagnostic tool for Barrett's esophagus
… quantitative information on different aspects of tissue morphology and biochemistry. Using this information, diagnostic algorithms will be developed, optimized and displayed to the physician through a useful interface.
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Applications of quantitative phase imaging for pathology
… Quantitative phase imaging (QPI) of unstained tissue provides information on the refractive index distribution, or tissue morphology, with nanometer level sensitivity. Subtle morphological changes in both the epithelial and stromal regions of tissue, which are not visible in stained tissue …
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Tissue-material interactions : bioadhesion and tissue response
Diverse interactions between soft tissues and implanted biomaterials directly influence the success or failure of therapeutic interventions. The nature and extent of these interactions strongly depend on both the tissue and material in question and can presumably be characterized for any given …
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Method for quantitative analysis of glycosaminoglycans and type II collagen in chondrocyte-seeded articular cartilage scaffolds with varied cross-linking density
Articular cartilage tissue engineering is a useful tool to study and enhance the wound healing processes of articular cartilage in vivo. Current tissue engineering scaffolds for articular cartilage are produced by cross-linking type II collagen with glycosaminoglycans (GAG), creating pores in the …
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Integration of Spatial Transcriptomics with Chromatin Images Using Graph-Based Autoencoder Identifies Joint Biomarkers for Alzheimer’s Disease
Tissue development and disease lead to changes in cellular organization, nuclear morphology, as well as gene expression. Spatial transcriptomic technologies, such as STARmap and 10x Visium, allow the joint measurement of these different modalities in whole tissue sections.1,2 However, methods for …
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THE EFFECT OF SDF1α ON SKELETAL MUSCLE REGENERATION AFTER COMPARTMENT SYNDROME INJURY
… CXCR4 receptor and has been suggested to enhance tissue vascularization. In this preliminary study, we tested the effects of SDF1α treatment on the recovery of skeletal muscle function and tissue morphology in a rat compartment syndrome (CS) injury model. We have previously demonstrated that this …
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Investigation of respiratory surfactant A protein in middle ear epithelium
… simple histological stains to study cell and tissue morphology of the rodent middle ear. We used immunohistochemistry and protein electrophoresis to identify surfactant A protein as well as four cytokeratins expressed in lung cells. Results: We have demonstrated that surfactant protein A is …
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An investigation of remote non-contact photoplethysmography and pulse oximetry
… effects and some characteristics of light-tissue interaction that underlie pulse oximetry. A device is then described that is capable of capturing two photoplethysmograph (PPG) signals simultaneously in a multiplexed fashion. The device is comprised of a complementary metal oxide …
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Phenotypic characterisation of the tremor mutant and AAV mediated aspartoacylase gene transfer in the rat model of Canavan disease
… N-acetyl-aspartate levels, changes in cell and tissue morphology, and physical and behavioural deficits including mild akinesia and loss of normal motor coordination and balance. Parallel to this work was the development of a gene transfer approach to treat Canavan disease, involving …
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Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… of diverse somatic mutations across large tumour tissue sections. Bayesian algorithms designed in the study generate quantitative clonal maps, effectively tracing cancer evolution in tissue space while accommodating multiple forms of biological and technical variability. Despite inherent …
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Exploring the Soft Tissue of the Archosaurian Feeding System through Evolutionary and Developmental Temporal Space
… which included diversification in teeth morphology. Different teeth morphology allowed tetrapods to take advantage of different ecological niches through food specialization. As useful as teeth are, we can see the repeated development of edentulous (=toothless) system throughout the …
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Major Collateral Vessels Develop from Pre-existing Small Arteries through RAC2/NOX2 Independent Mechanisms
… of hindlimb perfusion and preservation of distal tissue morphology. Chapter III investigated BMC and antioxidant therapy in the age-related impairment of collateral growth. Aging, like all cardiovascular disease risk factors is associated with elevated ROS and impaired collateral growth. Studies …
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