Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Tissue microarrays"”.
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Immunhistochemischer Algorithmus zur Diagnostik maligner Keimzelltumoren des Hodens
… Therapie unerlässlich. Mithilfe von Tissue-Microarrays sind 10 bereits bekannte als auch neue immunhistochemische Marker für die pathologische Diagnostik maligner Keimzelltumoren des Hodens untersucht worden. Normales Hodengewebe zeigte keine Expressions der geprüften Marker, …
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Estudio clínico-patológico e inmunohistoquímico de los carcinomas cutáneos escamosos de alto riesgo de cabeza y cuello
… de 116 pacientes con CCE y la construcción de tissue microarrays (TMAs).
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Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
… mittels immunhistochemischer Färbungen an tissue microarrays von 137 GIST, 15 Leiomyomen und 11 Leiomyosarkomen bestimmt. KIT-Expression wurde ausschließlich in GISTgefunden, während Leiomyosarkome erstmalig PDGFRA-Expression aufwiesen. AKT1 und ERK2 wurden im Vergleich zu den leiomyogenen …
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Pancreatic Ribonuclease Functions As An Epidermal Growth Factor Receptor Ligand Independently of Its Enzyme Activity and Contributes to Cetuximab Resistance
… activated EGFR expression in human pancreatic tissue microarrays further supports the pathological relevance of hRNase5. Strikingly, hRNase5 also enhances resistance to cetuximab therapy in pancreatic cancer. Thus, there may be an interplay between serum RNase and overexpressed EGFR in human …
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Tumour Localisation in Histopathology Images
… manual annotations. As an exemplar, human breast tissue microarrays stained with estrogen receptor are considered.<br/><br/>Methods for automated tumour localisation are described with a focus on capturing structural information in tissue by adopting superpixel properties in a rotation invariant …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… of primary CNS tumors through comprehensive tissue microarrays. Together, our approach and results provide a translational avenue for the detection and treatment of brain tumors.
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… HER4, HRG, KI67 and TUNEL was performed on HSPC tissue microarrays. Correlations between target protein expression and the outcomes time to biochemical relapse and overall survival were determined. Result High expression of HER/HRG was correlated with improved prognosis particularly in androgen …
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Computational methods for cancer diagnosis and prognosis from FT-IR spectroscopy data
… Manual histologic assessment of stained tissue forms gold standard of diagnosis and limits speed and accuracy in clinical practice and research of prostate cancer diagnosis. Outcome prediction by clinical, pathologic, imaging and computational tools outperforms manual ad hoc decisions, …
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Analysis of breast tissue microarray spots
Tissue microarrays (TMAs) are a high-throughput technique that facilitates the survey of very large numbers of tumours, important both in clinical and research applications. However, the assessment of stained TMA sections is laborious and still needs to be carried manually, constituting a …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… on WT cell lines and paraffin-embedded WT tissue sections. Tissue microarrays were constructed to improve the efficiency of this process and the most prominent marker was also validated by immunohistochemical protein staining, to prepare it for clinical use. The two proteins found to have …
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Explorative studies to understand if aldehyde dehydrogenase (ALDH) expression in colon cancer can be exploited as a target for therapeutic intervention. Expression profiling of ALDH7A1 in colorectal cancer
… GLUT-1 were co-expressed in CRC xenografts and tissue microarrays (TMAs) revealing hypoxia also impacts on ALDH7A1 expression in clinical samples. Both ALDH1B1 and ALDH7A1 were shown to be highly expressed in all patient samples, however, in-depth mechanistic studies are required to fully …
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FANCD2 in relation to BRCA2 mutated breast cancer
… and FANCD2, take over (Kais et al., 2016). Tissue staining for the active unit of telomerase (hTERT) and FANCD2 was performed on 470 BC samples on tissue microarrays (TMAs). It was evaluated whether overexpression of these proteins in the cell nuclei were associated with clinicopathological …
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Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
… the aforementioned genes in two pre-constructed tissue microarrays (TMAs) comprising 270 retinoblastoma patient tumours. Results show 1q gain (3-10 copies) in 136/262 (52%), 6p gain in 127/262 (48.7%), MYCN gain in 18/265 (6.8%) and MYCN amplification (>10 copies) in 20/265 (7.5%) patient …
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A bioinformatics meta-analysis of differentially expressed genes in colorectal cancer
… the expression profiles of cancerous and normal tissue by performing high throughput gene expression profiling. While many such studies have been performed, the resulting lists of differentially expressed genes tend to be inconsistent with each other, suggesting that there are some false …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… The mouse xenografts, liver biopsy and tissue microarrays unveiled overexpression of DCAMKL-1 during chronic HCV infection and cirrhosis, and in the HCV-replicon expressing cells. We further demonstrate that HCV results in excessive expression of a-fetoprotein, cytokeratin-19, c-Myc, and …
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The role of tissue inflammation in Kenyan women with breast cancer
… of the International TIL working group. Tissue Microarrays (TMAs) of tumour were constructed, stained with immunohistochemistry for CD3, CD4, CD8, CD68, CD20 and Fox P3, scanned and analysed on the Leica Aperio platform. Cytokine profiles of ER positive and Triple Negative BC were …
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
… were measured by immunohistochemistry in tissue microarrays (TMAs) of patient breast tumour samples. Membrane IGF-IR staining correlated inversely with HER-2 expression (p = 0.026). In conclusion, these data suggest that increased signalling through alternative RTKs may play a role in …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… tumoral immunohistochemical expression in 262 tissue microarrays created from tumor specimens of patients with surgically resected stage I-II lung adenocarcinoma and correlated it with patient clinic-pathological characteristics including smoking status, histological differentiation and …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… malignancies by screening one of the largest tissue microarrays in North America. YB-1 is an oncogenic transcription/translation factor, which is over-expressed in the majority of malignancies, including breast cancer. In the cohort of 4049 primary breast tumours, we show that YB-1 is a strong …
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Immunohistochemical and molecular studies on ovarian cancer progression and prognosis
… and Cancer Study and Malmö Preventive Project. Tissue microarrays (TMAs) were constructed with primary ovarian tumour samples from all cases, omental deposits from 33 cases and benign-appearing fallopian tubes from 38 cases. In addition, an independent gene expression data set with 285 EOC cases …
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