Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Tissue microarray"”.
-
Analysis of breast tissue microarray spots
Tissue microarrays (TMAs) are a high-throughput technique that facilitates the survey of very large numbers of tumours, important both in clinical and research applications. However, the assessment of stained TMA sections is laborious and still needs to be carried manually, constituting a …
-
Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
PURPOSE: Tissue microarray (TMA) has been utilized for rapid profiling of molecular tumor markers and compares well to results obtained by standard methods. Caveolin-1 is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular …
-
On information organization and information extraction for the study of gene expressions by tissue microarray technique
… profiles characterizing specific disease states. Microarrays allow the tracking and the translation of genome sequences into gene functions, leading to the identification of highly informative genes and pathways with a potential impact on understanding disease development and progression. These …
-
Molecular analysis and application of tissue microarray technology to the histopathological and immunohistochemical analysis of cervical adenocarcinoma
… increasing in real terms. In this study, tissue microarray technology was used to study the morphological features of cervical adenocarcinoma archival donor blocks, to evaluate the immunoprofile of a large set of cervical adenocarcinomas with an extended panel of antibodies to compare the …
-
Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence.
In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) …
-
Bioinformatics analysis of liver and adipose tissue microarray data from periparturient dairy cattle and development of a web-based ruminant specific microarray database
To-date bovine liver and adipose tissues have been investigated through several molecular techniques. However, for the most part molecular work in these tissues has been conducted using a reductionist approach discussing the individual genes, proteins or pathways. This approach does not necessarily …
-
Functional In Vivo Screen Identifies Pygo2 As A Putative Gene to Promote Prostate Cancer
… ADAMTS2, IGFBP3 and downregulation of KISS1. Tissue microarray analysis indicated that PYGO2 upregulation was correlated with higher Gleason score in prostate cancer. Collectively, the results suggest PYGO2 as a potential prognostic marker as well as a therapeutic target. Additional functional …
-
Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
… cell lines. Furthermore, using a ccRCC specific tissue microarray, these subunits are also observed to be depleted at high frequency in tumour tissues. Surprisingly, the proportion of SMARCC1-deficient ccRCC tumours is similar to the well-established ccRCC drivers, VHL and PBRM1 and that more …
-
Pathologic Markers of Prognosis In Ampullary Carcinoma
… therapy given, and the patient outcomes. A tissue microarray (TMA) of 95 surgically resected ampullary specimens was also constructed to examine whether there is a correlation between classical immunohistochemical profiles for intestinal and pancreaticobiliary tumors and their histologic …
-
Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies
… several common deregulations in a large (n=208) tissue microarray of ULMS compared to GI smooth muscle, myometrium, and leiomyoma controls. Our results suggest that significant loss of smooth muscle and gynecological differentiation markers is common in ULMS, a finding that could help render …
-
INVASIVE BLADDER CANCER - Aspects on staging and prognosis
… prognostic values of expression profiling and tissue microarray (TMA) in high-risk bladder cancer are investigated in Papers V and VI. Results and conclusions: 1) Diagnostic delay in patients with T1 tumours might have an adverse effect on the prognosis. 2) Treatment delay in patients with …
-
Novel Cutaneous Human Papillomaviruses and Biomarkers in the Skin Lesions
… investigated in 25 SCC and 64 KA by tissue microarray. The anti-apoptotic Bcl-xL was detected in 84% of the SCC and in 15% of KA, indicating a possible distinguishing marker. HPV DNA was detected in 22% of SCC and 27% of KA and eighty percent of the HPV isolates belonged to the …
-
Hypoxic gene regulation and oncogenic pathways in neuroblastoma
… physiological oxygen levels (5% O2). Subsequent microarray analysis showed that HIF-2α induced genes, previously identified as hypoxia regulated, at this physiological oxygen level. Several of these genes have been implicated in tumorigenic processes and correlated to adverse patient outcome in …
-
NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… cells. In human tumors, expression and tissue microarray analysis revealed that mRNA and protein levels of the potent NAD+ hydrolase CD38 are diminished in prostate cancer. CD38 protein levels were high in normal prostate cells and low in cancer prostate cancer cell lines, which …
-
Identification of gene expression changes in human cancer using bioinformatic approaches
… expression profiling techniques, such as microarrays, has provided powerful new tools to identify such changes and researchers are now faced with an explosion of gene expression data. Processing, comparing and integrating these data present major challenges. I approached these challenges …
-
Engineering Lipid Nanoparticles for sIRNA Delivery to Silence Identified Targest in Cancer Cells
… <p>Chapter 4 explores prostate cancer using tissue microarray (TMA) analysis to identify stagespecific molecular targets. Through advanced analysis, potential targets are revealed for future RNAi-based therapies, supporting a broader application of siRNA delivery platforms developed …
-
The Role of Nucleolin In B-Cell Lymphomas and Fas-Mediated Apoptotic Signaling
… localization changes in transformed cells. In a tissue microarray analysis we showed that although total nucleolin levels did not correlate with patient outcome, including progression free survival and overall survival, the nucleolin levels did correlate with proliferative staining. We developed …
-
The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
… mice. In a publicly available microarray gene expression dataset, high levels of DOT1L gene expression in tumours correlated with high levels of MYCN gene expression and poor patient survival independent of MYCN amplification, age at diagnosis and disease stage. I have also …
-
The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… introduces an outcome-linked human ostoesarcoma tissue microarray (new tool) used to detect and validate protein biomarkers across a variety of patients and an ex vivo pulmonary metastasis assay (new reagent) that allows real-time assessment of metastatic progression in a relevant …
-
Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. In study I, we demonstrated that 20% of the patients …
Page 1 of 2