Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Tissue mechanics"”.
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Modulating tissue mechanics to increase oxygen delivery to tumors
… hypoxia are needed. Two factors affect tissue oxygen levels: oxygen supply via blood vessels and oxygen consumption by cells. I focused on improving supply to combat hypoxia. Two vessel abnormalities limit supply. Compression decreases the density of perfused vessels supplying tumors. …
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Computational modeling of the tissue mechanics in rheumatic heart disease patients
… will facilitate the investigation of heart biomechanics, focusing on the impact of myocardial elastic material behavior, including compliance (stiffness), muscle fiber orientation angles, and directionally dependent properties (anisotropy coefficients). Using CMR images, three-dimensional (3D) …
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Prostate Tissue Motion Tracking and Ultrasound Elastography Using Tissue Mechanics Derived Constraints
Current prostate cancer detection methods can be costly to obtain, such as magnetic resonance imaging, or lack specificity, such as a digital rectal exam. Ultrasound elastography, a method that can be used to develop and test algorithms that output stiffness, strain, and displacement data captured …
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Development of a Micromorphic (Multiscale) Material Model aimed at Cardiac Tissue Mechanics
Computational cardiac mechanics has historically relied on classical continuum models; however, classical models amalgamate the behaviour of a material's micro-constituents, and thus only approximate the macroscopically observable material behaviour as a purely averaged response that originated on …
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Finite Element Analysis of and Multiscale Skeletal Tissue Mechanics Concerning a Single Dental Implant Site
… concerning the biomechanical nature of skeletal tissue. Implants are placed in topologically and physiologically complex sites, and major disagreement exists in literature about various aspects concerning their modeling and analysis. Current research seeks to improve the implementation of an …
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Biological tissue mechanics with fibres modelled as one dimensional Cosserat continua: applications to cardiac tissue in healthy and diseased states
Classically, the elastic behaviour of cardiac tissue mechanics is modelled using anisotropic strain energy functions capturing the averaged behaviour of its fibrous microstructure. The strain energy function can be derived via representation theorems for anisotropic functions where a suitable …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two different types of signals remains poorly understood. Here, I investigated how tissue …
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Measurement and modeling of brain tissue and engineered polymer response to concentrated impact loading
… organs in our bodies. To predict how brain tissue deforms, and to protect it from deforming in ways that reduce our cognitive function, we must be able to measure, model, and ideally replicate brain tissue mechanics. While this is a grand challenge that many have sought to address, this need …
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IN-VIVO SCLERAL AND CORNEAL BIOMECHANICS AS BIOMARKERS IN OPHTHALMIC PRACTICE
… between biomechanical properties and abnormal tissue mechanics become more and more apparent in the field of ophthalmology, demand for in-vivo determination of biomechanical properties have also increased. While devices like the Ocular Response Analyser (ORA) have made the determination of …
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In vivo and in vitro guidance of developing neurons by mechanical cues
… the spatiotemporal dynamics of embryonic brain mechanics, are still largely uncharacterised. Here, I have identified a role for tissue mechanics in embryonic axon guidance in vivo, using retinal ganglion cell (RGC) axon outgrowth in the developing Xenopus laevis optic tract (OT) as a model …
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Mechanical characterisation of rodent spinal cord tissue in health, trauma and disease
Spinal cord tissue is amongst the softest tissues in the body. Studying its mechanical properties is important as many cell types in the spinal cord react to their mechanical environment. Injury and disease can change spinal cord tissue stiffness, and conversely, altered tissue stiffness can affect …
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Coupled theoretical and experimental methods to characterize heterogeneous, anisotropic, nonlinear materials: application to cardiovascular tissues
The Generalized Anisotropic Inverse Mechanics (GAIM) method is able to provide general tissue characteristics in terms of stiffness, anisotropy strength, and preferred orientation. It allows for the computational dissection of samples, capturing regional differences within a single sample …
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Multiscale models for the degradation, damage, and failure of collagen-based soft tissues
… deformation, degradation, and failure of soft tissues can inform the work of tissue engineers, clinicians who treat soft tissue injuries, and biologists who study the growth and development of soft tissues. Increasingly, mechanical models for tissues that couple multiple length scales include …
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MODELING OF THE CHEMOMECHANICAL INTERACTIONS BETWEEN CELLS AND THE EXTRACELLULAR MATRIX
… we examine the rheological characteristics of tissues densely packed with cells. Our analysis reveals an unexpected transition from compression softening to compression stiffening in these tissues because of the presence of cells. This finding is crucial for understanding how tissues endure and …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
Cell-level and tissue-level mechanical properties are key to healthy biological functions, and many diseases and disorder arise or progress due to altered cell and tissue mechanics. Pulse electric field (PEFs), which employ intense external electric fields to cause electroporation, a phenomenon …
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Development of a Biaxial Testing System for Research of Soft Tissue Biomechanics using Laboratory Models
<p>The rupture of the cap tissue layer of a fibroatheroma in human coronary vessels is considered the key event leading to the formation of a thrombus and myocardial infarction, resulting in more than half a million deaths in the US every year. In this study, we are interested in investigating the …
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Multiscale modeling and simulation of deformation and failure mechanisms of hierarchical alpha-helical protein materials
… processes such as mechanotransduction, cell mechanics, tissue mechanics and remodeling. Whereas the mechanics of engineered materials has been widely investigated, the deformation and failure mechanisms of biological protein materials remain largely unknown, partly due to a lack of …
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The Influence of Biomechanics on Acute Spatial and Temporal Pathophysiology Following Blast-Induced Traumatic Brain Injury
… the detonation source. Upon contact, biological tissues throughout the body undergo deformation at high strain rates and then return to equilibrium following a brief negative pressure phase. This mechanical disruption of the tissue is known to cause oxidative stress and neuroinflammation in the …
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Role of multicellular organisation in mesoderm differentiation
… are spatiotemporally coordinated with changing tissue architecture. Typically, changes in tissue architecture are thought to be a downstream consequence of changes in cell fate, which in turn are caused by change in exposure to secreted extracellular signalling molecules. However, recent …
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Deformation and fracture of soft materials for cartilage tissue engineering
… treatments available. The developing field of tissue engineering offers an alternative to the currently used full joint replacement. Restoring damaged cartilage through tissue engineering would enable an active lifestyle to be recovered and retained, without restrictions to joint mobility. This …
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