Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Tissue inflammation"”.
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The role of tissue inflammation in Kenyan women with breast cancer
… of the International TIL working group. Tissue Microarrays (TMAs) of tumour were constructed, stained with immunohistochemistry for CD3, CD4, CD8, CD68, CD20 and Fox P3, scanned and analysed on the Leica Aperio platform. Cytokine profiles of ER positive and Triple Negative BC were …
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Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging
… aging are often accompanied by chronic low-grade inflammation in adipose tissue. Metabolic endotoxemia (elevated circulating lipopolysaccharide [LPS] level) is the inducer of systemic and adipose tissue inflammation and dysfunction, which is developed during obesity and aging. As a soluble pattern …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase (HDAC) activity and …
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Influence of body weight gain on insulin regulation, adipose tissue inflammation and lipid metabolism in equines
… human medicine obesity is linked with a systemic inflammation deriving from adipose tissue (AT). Especially abdominal AT produces inflammatory cytokines and is therefore a risk factor for metabolic diseases in humans. However, in equines systemic inflammation linked to obesity is still …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
… A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE DEVELOPMENT OF OBESITY AND TYPE 2 DIABETES. MICE DEFICIENT IN IRF3 DEVELOPED OBESITY AND TYPE 2 DIABETES WHICH IS ASSOCIATED WITH INCREASED ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION. FOR MKP5, WE FOUND …
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The Role of Adipose-Specific Free Fatty Acid Receptor 2 in Obesity and Associated Metabolic Dysfunction
… are often characterized by chronic adipose tissue inflammation, driving systemic insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2/GPR43) has emerged as a potential modulator of adipocyte function, inflammation, and metabolism. To investigate the role of …
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Adiponectin and Toll-Like Receptor 4: Important Adipocyte Modulators of Systemic Glucose and Lipid Metabolism
… features of an unhealthy hypertrophic adipose tissue are decreased adiponectin secretion and increased adipose tissue inflammation. Released almost exclusively from adipocytes, adiponectin exerts potent insulin sensitizing effects on peripheral tissues. Using a series of inducible mouse models, …
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Linking Inflammation to Tumorigenesis In A Mouse Model of High-Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter?
… the basis for inferring a causal relationship. Inflammation plays a role in colon cancer progression and HFD has been reported to increase inflammation; however, the inflammatory effects of HFD in colon cancer have yet to be established. We sought to examine the relationship between HFD …
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Reduced adipose tissue hypoxia as a potential mechanism by which exercise and/or low fat diet reduces inflammation in obese mice
… significant reductions in the visceral adipose tissue inflammation. Adipose tissue hypoxia, perhaps involving cell stress or death, has been suggested as one of the major initiating events inciting inflammation. Purpose- The purpose of the proposed study was to investigate adipose tissue hypoxia …
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Suppression of pro-inflammatory signalling pathways by sulforaphane
Low-grade inflammation has been associated with the risk of chronic pathologies including cancer, atherosclerosis and type 2 diabetes. Epidemiological studies demonstrate an inverse correlation between diets rich in cruciferous vegetables and risk of cancer, cardiovascular disease mortality and …
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
… coupled with enhanced complement activation, tissue inflammation and higher lethality. Lipidomics profiling of the purified sNS1 from wild-type and TS-virus revealed that they carried different lipid classes. Interestingly, treatment of human PBMCs with purified sNS1 from TS-virus resulted in …
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Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
… The early events that initiate inflammation in the adipose tissue during obesity are not well defined. It is unclear whether the recruitment of CD8 T cells to the adipose tissue during onset of obesity occurs through antigen-dependent or -independent processes. We have previously …
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DUSP5 Regulation of Inflammation and Insulin Signaling
Adipose tissue inflammation links obesity to insulin resistance and type 2 diabetes (T2D). Chronic inflammation of adipose tissue is characterized by increased expression of tumor necrosis factor ? (TNF?). TNF? stimulates signaling of mitogen-activated protein kinases (MAPKs) within adipocytes …
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Hepatic Element Concentrations and Gross and Histological Examinations of Spring Migrating Lesser Scaup (Aythya affinis) in the Upper Midwest
… and histological examination of several tissues were also completed on the lesser scaup collected. In this study, the hepatic concentrations of arsenic, boron, cadmium, calcium, chromium, copper, iron, lead, magnesium, manganese, mercury, molybdenum, nickel, potassium, sodium, thallium, …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some individuals develop healthy obesity and are resistant to obesity-associated metabolic diseases; whereas others readily develop one or more of these disorders. The reasons for such …
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The role of adipose tissue in the pathogenesis of non-alcoholic steatohepatitis
… conditions are also associated with adipose tissue inflammation and dysfunction. In response to overfeeding, some individuals develop healthy obesity and are resistant to obesity-associated metabolic diseases; whereas others readily develop one or more of these disorders. The reasons for such …
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Dynamic Behaviors of Langerhans Cells In Situ
… LCs sense injurious stimuli and contribute to tissue inflammation as well as initiate the antibody- or cell-mediated specific responses to pathogenic organisms. These events represent pivotal occurrences in the instigation of the immune response, and thus are important targets for experimental …
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Immune memory and activation markers in systemic lupus erythematosus
… to self-antigens, immune complex deposition, tissue inflammation and destruction. SLE manifestations, prevalence and severity vary among different populations and ethnicities. Even today, the pathogenesis of SLE remains unclear. This complex autoimmune disease is more common in Asians …
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Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses
… (axon drop out), axon degeneration, fibrosis and inflammation in alcohol- and formaldehyde-injected nerves compared to control nerves. Formaldehyde injection induced greater fibrosis and inflammation than alcohol.Conclusions and Clinical Relevance: Alcohol injection induced effective neural …
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Palmitic Acid Activation of Dendritic Cells: Implications for Type 2 Diabetes
… of immune cells into visceral adipose tissue is observed in type 2 diabetes development. Monocytes are recruited to obese visceral adipose tissue in large numbers and retain the ability to differentiate into dendritic cells, important antigen presenting cells in the immune system. …
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