Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Tissue imaging"”.
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Multi Array, Conformable Ultrasound Patch for Soft Tissue Imaging
Medical ultrasound imaging is a rapidly growing field due to its safety and affordability when compared to other imaging modalities such as MRI and X-Ray. Ultrasound transducers are made in various configurations from dense 2-D arrays for volumetric imaging to single element needle like transducers …
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Characterizing Muscle and Subcutaneous Adipose Tissue Imaging Phantoms for NMR Application
Medical imaging techniques are being increasingly used to derive quantitative information, requiring a new type of imaging phantom for validation. Here, we describe the T2 relaxation properties of an emulsified two-phase imaging phantom for validating a nuclear magnetic resonance (NMR) sensor for …
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Piezoelectric single crystal based one-dimensional phased array for breast tissue imaging
… non-ionizing, low-cost, and provides real-time imaging, monitoring, and therapy. However, conventional ultrasound probes are rigid, pressure-required, and operator-dependent. Replacing rigid transducers with conformable ultrasound transducer arrays can allow image acquisition on curved body …
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Photoacoustic imaging: development of near infrared platforms for non-invasive deep-tissue imaging
"Fluorescence imaging has been employed as the gold-standard in molecular imaging. However, despite its ubiquitous usage, this technique is only viable for studying molecular interactions within a cellular system. Fluorescence imaging is limited by optical diffusion, at depths greater than 1 mm, …
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Development Of Matrix Assisted Ionization Methods For Characterization Of Soluble And Insoluble Proteins From Native Environments By Mass Spectrometry
… analysis and for surface methods useful for tissue imaging but is limited for structural characterization due to poor fragmentation and is ill suited for liquid based separation methods. The research presented here relates to new ionization methods that encompass the benefits of ESI and …
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Development of high-speed two-photon microscopy for biological and medical applications
… powerful microscopic technologies for in-vivo 3D tissue imaging up to a few hundred micrometers. It has been finding important applications in neuronal imaging, tumor physiology study, and optical biopsy. A practical limitation of TPM is its slow imaging speed (0.3 1 frames/s). We designed …
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Harmonic phase based low coherence interferometry : a method for studying the dynamics and structures of cells
… investigation as a means for optical deep tissue imaging.
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Extending imaging depth of multiphoton microscopy
… fluorescence microscopy has capability of deep tissue imaging with biological samples. However, because of the inhomogeneity of the refractive index in biological samples, the wavefront of the excitation light is often distorted. Due to the distortion of the wavefront, the point spread function …
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Nanoshells in vivo imaging using two-photon excitation microscopy
… for applications in small animal blood vessel imaging. Two types of gold-silica nanoshells excitable by NIR lasers are investigated: Type 1 nanoshells can be excited with a sub-mum NW laser, whereas Type 2 nanoshells can be excited with a NW laser in the micrometer range. Using NIR microscopy …
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Computational microscopy for sample analysis
… explores the novel application of computational imaging methods to fluorescence microscopy and oblique illumination microscopy. In fluorescence spectroscopy, we have developed a novel nonlinear matrix unmixing algorithm to separate fluorescence spectra distorted by absorption effect. By extending …
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Using simulation to estimate probability density functions of bound water molecules with DSI
… basis by which high resolution diffusion imaging derives information about fiber alignment and diameter, we simulated a model diffusion experiment employing a random walk paradigm. A simulation of a model diffusion spectrum imaging experiment was written in Java in order to compare the …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
… into mirror sections for mass spectrometry-based tissue imaging and H&E staining. There was a significant reduction (P < 0.05) in brain metastatic burden in the group treated with 10 Gy WBI alone compared to no treatment. Simvastatin by itself did not significantly reduce the brain metastatic …
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Creation of brain tissue-mimicking material and multi-material gradient 3D printer for magnetic resonance elastography phantom
… resonance elastography (MRE) is a non-invasive tissue imaging method that measures shear stiffness. While MRE has many benefits, it is not currently used clinically for scanning the human brain, mainly because it has not been validated with independent mechanical property testing methods. This …
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Development of chemical tools for studying biology with light: Photoactivatable donors and photoacoustic probes
… activatable contrast agents for photoacoustic imaging, an emerging deep-tissue imaging modality. To address a lack of modular activatable probes for this imaging technique, we combined the analyte specificity of DNA aptamers with commercially available fluorophores to show the feasibility of a …
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… formalin fixed paraffin embedded (FFPE) clinical tissue specimens, opening the doors for direct translational insights from FFPE tumor tissue banks in hospitals. In the second part, we present an integrative platform using mass spectrometry imaging, phosphoproteomics and multiplexed tissue imaging …
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Fundamental aspects of imaging matrix assisted laser desorption ionisation mass spectrometry.
… laser desorption/ionisation mass spectrometry imaging is a recent addition to the existing family of molecular imaging technologies. It has the capacity to map the distribution of molecules within a biological tissue section, without the need for radionuclide or fluorescent labelling …
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In vivo human computed optical interferometric tomography
… optical interferometric tomography. Computed imaging has made great advances in a wide variety of fields, greatly improving the diagnostic capability of each underlying imaging modality. Computed imaging techniques such as defocus and aberration correction in optical interferometric …
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Spatially precise in situ transcriptomics in intact biological systems
Biological tissues are composed of cells of diverse types and states that are spatially organized with nanoscale precision over extended length scales to perform coordinated functions. Understanding patterns of gene expression in tissues is needed to understand complex cellular behaviors in health …
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Sample preparation methodologies for MALDI-MS imaging and related topics.
… evaluated as a technique for the detection and imaging of antiasthmatic compounds in lung tissue. Four compounds were assessed initially with conventional MALDI MS experiments, followed by both direct and indirect tissue imaging experiments. Pharmaceutical tablet formulations have also been …
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The Synthesis and Evaluation of Non-Targeted Near-Infrared Heptamethine Molecular Probes
… near infrared dyes make these ideal for cell and tissue imaging. The work within this thesis focuses on the development of three families of NIR dyes (linear, rigid and substituted polymethine) and these are actively compared against the clinical standard Indocyanine Green (ICG) and its structural …
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