Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Tissue factor (TF)"”.
-
On the induction of inflammatory reactions by Streptococcus pyogenes
… is a surface-bound streptococcal virulence factor with antiphagocytic properties. M proteins can be released from the bacterial surface, and in the present thesis we report that soluble M1 protein is a potent activator of monocytes and T cells. M1 protein-induced monocyte activation involves …
-
Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Cardiac hypertrophy was achieved by aortic …
-
The tissue factor-factor VII(a) complex in blood coagulation
… the coagulation cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream …
-
Leukocyte Response to Elastin-Like Polypeptide Coatings
… polyethylene and uncoated MylarTM. In the bulk, tissue factor (TF) expression (monocytes: ELP1 = 38.6 ± 16.3 %, ELP4 = 33.9 ± 18.1 %) and platelet-leukocyte aggregates determined by CD61 (monocytes: ELP1 = 63.1 ± 17.1 %, ELP4 = 61.8 ± 16.8 %; granulocytes: ELP1 = 62.7 ± 17.0 %, ELP4 = 60.5 ± 20.1 …
-
A study of the regulation of oestrogen receptor alpha by tissue factor in breast cancer cells
Increased expression of tissue factor (TF) has been associated with invasive forms of breast cancer. In contrast, the expression of oestrogen receptor alpha (ERa) in breast cancer cells is associated with well differentiated breast tumours, with a low invasive potential. The aim of this study was …
-
Computational Modeling And Simulation Of Thrombus Formation
… to obstruction of blood vessels, resulting in tissue ischemia or death. This study is aimed to understand the cell-biology and biophysics, at the molecular level, of thrombosis in a blood vessel. We first review the biology underlying thrombosis and the previous mathematical models of thrombus …
-
Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
… coagulation is known to exist, where coagulation factor VII (FVII) and tissue factor (TF) are considered to be pivotal players. In this thesis the crosstalk between inflammation and coagulation in acute pancreatitis (AP) has been investigated. The results from the first paper, where active site …
-
Mesenchymal stem cell therapy for the treatment of myocardial infarction
… initiator of the coagulation cascade initiator tissue factor (TF) on MSC was detected in high levels on the surface of these cells. MSC-derived TF antigen was catalytically active, capable of supporting thrombin generation in vitro and enhancing platelet-driven thrombus deposition on collagen …
-
Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… is an important regulator of coagulation and a cofactor of Activated Protein C (APC). TM and APC modulate the homeostasis of thrombosis, diminish the release of inflammatory mediators, and inhibit the immune cell infiltration into islet grafts. Moreover, CD47 binds to signal regulatory protein …
-
Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
… of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent manner. Nearly all studies of GLA domain-containing coagulation factors, and coagulation in general, have utilized supraphyisologic …
-
Plättchenassoziierter Tissue Factor als schnell aktivierbarer, intravaskulärer Starter des menschlichen Gerinnungssystems
Der Tissue Factor (TF) der Gefäßwand gilt heute als der wichtigste Starter der menschlichen Blutgerinnung. Es wird davon ausgegangen, dass die Lokalisation von TF innerhalb der Gefäßwand unter physiologischen Verhältnissen eine strikte Trennung von den plasmatischen Gerinnungsfaktoren …
-
Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
… the blood-clotting cascade is initiated when factor VIIa (fVIIa, other clotting factors are named similarly) binds to human tissue factor (TF), a 29 kDa integral membrane protein. The TF/fVIIa complex in turn activates fX and fIX, eventually concluding with clot formation. Several X-ray …
-
Effect of resection of localised pancreatic cancer on tissue-factor promoted pathways of thrombosis, cell invasion and angiogenesis
… of TE in PC has been reported as high as 57%. Tissue factor (TF) bearing microparticles (MP) have recently been shown to promote thrombosis. The biological link between cancer haemostasis, cell invasion and angiogenesis remains unclear. These three indices may be driven by PC cells directly, be …
-
¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… and Aim Venous thromboembolism (VTE) is a multifactorial disease that includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE patients can be classified on the basis of the risk factor(s) that trigger the thromboembolic event. Indeed, up to 50% of VTE events occur in absence of …
-
Contribution of different types of phospholipids in blood coagulation
… on γ-carboxyglutamate-rich (GLA) domains of factor X (fX) and prothrombin as representative GLA domains of clotting factors, which have been the subject of several protein-phospholipid interaction studies. Based on the results of this project, we proposed a new mechanism for the binding of …