Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tissue engineering and regenerative medicine"”.
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Human blood-derived extracellular vesicles in tendon tissue engineering and regenerative medicine applications
Tendon disorders, a major healthcare and socioeconomic burden worldwide, are often challenging to solve due to the tendons limited regenerative capacity. The main therapies currently used do not tackle the etiology of tendon injuries and therefore, there is an urgent need for alternative approaches …
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Surface engineering, characterisation and applications of synthetic polymers for tissue engineering and regenerative medicine. Investigation of the response of MG63 osteosarcoma cell line to modified surface topographies, mechanical properties and cell-surface interactions using different synthetic polymers fabricated in house with various topographical features
… barriers in regards to discovering novel and enhanced biomaterials for various tissue engineering applications. The need for durable orthopaedic implants is on the rise to limit issues such as revision surgery. A promising pathway to enhance fixation is to accelerate the onset and rate of …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
Tissue Engineering and Regenerative Medicine fields of life science and engineering strive to address medical challenges to human flourishing. Innovative research has led to many advances in the past two centuries with regards to treatment of orthopaedic trauma, but better options for treatment of …
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Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process
… cells (MSC) are an important component of many tissue engineering and regenerative medicine (TE/RM) strategies. Their multipotential characteristics make them extremely useful as a source of cells for TE/RM applications. Adipose-derived stem cells (ADSC) represent one type of MSC and have many …
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Electrospun Dual Scaffolding System with Potential for the Tissue Engineering of Muscle-Tendon Junctions
… of people worldwide that suffer from limb loss and are in need of a prosthetic. In tissue engineering and regenerative medicine our goal is to one day be able to provide these patients with a fully functional limb instead of a prosthetic. Currently, we are far from realizing this goal. …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… thesis, we developed a reliable platform for engineering perfusable, microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In …
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The interplay of matrix rigidity and mechanical stretching for the development of artificial skin
Tissue engineering and regenerative medicine provides the possibility for generating organs in laboratorial settings as an off-the-shelf-technology that can provide an alternative therapeutic pathway for transplantations and replace non-functional organs. Many engineered tissues have been attempted …
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BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE
… high pressure zones exist along the tract and are referred to as sphincters. Sphincters maintain a closure tone and relax upon receiving the appropriate signal to allow movement of food. The GI tract performs 2 main functions: (1) peristalsis; a coordinated rhythmic contraction and …
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Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Identity in vitro
… in vitro expansion for stem cell therapies and tissue engineering applications. Controlling cell fate for biomedical interventions will require insight on all aspects that influence cellular properties. The resting membrane potential (Vmem) has proven to be a key parameter involved in cell …
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Mask Projection Microstereolithography 3D Printing of Gelatin Methacrylate
… a ubiquitous biocompatible photopolymer used in tissue engineering and regenerative medicine due to its cost-effective synthesis, tunable mechanical properties, and cellular response. Biotechnology applications utilizing GelMA have ranged from developing cell-laden hydrogel networks to cell …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
… vascular networks that sustain the viability and function of cells within human-scale organs after implantation remains a major challenge. Sacrificial templating has emerged as a promising strategy that could overcome this challenge by confining fabrication stressors to a temporary scaffold …
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Engineering Musculoskeletal Tissue: In vitro and in vivo evaluation of novel scaffolds and growth factors for bone regeneration
Introduction: The management of bony non-unions and large bone defects due to congenital deformities, trauma, degenerative disease, and oncological resection remains a complex challenge for orthopaedic surgeons. Currently, autologous bone grafting is the ‘gold standard’ treatment for non-unions and …
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Engineered, functional, human microvasculature in a perfusable fluidic device
Engineered, human tissue models will enable us to study disease more accurately, and develop treatments more economically, than ever before. Functional tissue grown in the laboratory will also provide a much-needed source for the clinical replacement of diseased or damaged tissues. A major …
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Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
… with an estimated number of three hundred thousand new cases and about two hundred thousand deaths annually. The 5-year survival rate of ovarian cancer is approximately 30% or less when diagnosed during the advanced stage. The detection of OC in advanced stages is partly due to non-specific …
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Keratin Microparticles for Drug and Cell Delivery
… family of proteins found within human hair, skin and nails, as well as a broad variety of animal tissue. Prior research suggests hydrogel constructs of keratin and keratin derivatives exhibit several mechanical and biological properties that support their use for tissue engineering and …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
… stem cells (MSCs) are very promising in tissue engineering and regenerative medicine because of their ability to differentiate into different type of cells including bone and cartilage. MSCs differentiation can be modulated using both chemical (i.e. proteins) and physical cues (ie. …
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Electro-mechanically interfacing with biology using piezoelectric polymer nanostructures
… wealth of stimuli that influence their function and behaviour. In fields where the focus is on artificially growing biological material, such as tissue engineering and regenerative medicine, it is important to consider this array of senses to ensure correct cell signalling and tissue development. …
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Development of Jetting Techniques for the Delivery of Mesenchymal Stromal Cells for Therapeutic Applications
… cells (MSC) are an important cell source for tissue engineering and regenerative medicine (TERM) and cell therapies. Intravenous injections (I.V.) injections and scaffold implantation are currently the predominant methods of MSC administration. However, both approaches have encountered serious …
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COLLAGEN AND ANTIOXIDANTS FROM SEA URCHINS: WASTE VALORIZATION CHALLENGES TOWARDS REGENERATIVE MEDICINE
… highly valuable collagen derived from by-product tissues such as the peristomal membrane, which can be used as an innovative biomaterial for tissue engineering. The remaining part of the waste (test and spines) can be an additional source of biologically interesting compounds. Indeed, it contains …
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Regulation and patterning of cell differentiation and pluripotency
… structure formation in applications such as tissue engineering and regenerative medicine. In this thesis, we explored the applications of controllable gene expression techniques in combination with engineering strategies in regulation and patterning of cell differentiation and pluripotency, …
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