Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 281 for “"Tissue damage"”.
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Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… of inflammatory caspase function following tissue damage signals and the action of TNF during sensitization in vertebrates.</p>
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Epithelial Memory of Resolved Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis
… inflammatory events, thus efficiently limiting tissue damage <em>via</em> rapid decrease of zymogen production. We propose that since activating mutations of KRAS maintain an irreversible ADM, they may be beneficial and under strong positive selection in the context of recurrent pancreatitis.</p>
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Bioprosthetic heart valves : ultrastructure and calcification
… to 72 hours. In order to assess the pre-fixation tissue damage arising from the hypoxic period and the resulting calcific degeneration after implantation, we used an ultrastructural damage score and transmission electron microscopy. Materials and Methods: In a step by step manner, three major …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… in AP. LFA-1 adhesive mechanisms play a role in tissue damage and leukocyte recruitment but not trypsinogen activation. Furthermore, neutrophil-derived MMP-9 mediates tissue damage and neutrophil-dependent trypsinogen activation. Rho-kinase signaling regulates trypsinogen activation, leukocyte …
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Penetration force measurements in the central nervous system with silicon electrodes
… major challenges in neural engineering is the tissue damage that occurs during insertion of microelectrodes into the central nervous system. The damage occurs as a result of the dimpling effect that is due to the insertion force. A method which can reduce the penetration force can also reduce …
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Inter-individual variation in saliva antioxidant status in relation to periodontal disease
… antioxidant capacity may limit oxidative tissue damage and improve the health of the gingival tissues. In this thesis, the antioxidant profile of saliva was assessed in relation to PD severity. Salivary protein carbonyl concentration was assessed as a biomarker of oxidative tissue damage. …
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Bilirubin Nanoparticle As An Anti-Inflammatory Therapy For Graft Versus Host Disease
… and/or radiation, given prior to HSCT can cause tissue damage. This non-specific tissue damage triggers cross-presentation of alloantigens to the donor immune cells, causing recruitment of leukocytes and production of inflammatory cytokines. Targeting this inflammation without affecting the …
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An investigation of the potential use of Tc-HMPAO-SPECT scanning in decompression illness.
… illness (DCI) may also sustain occult nervous tissue damage which is undetectable to standard clinical examination. Although unapparent in the acute phase of the disorder, such occult tissue damage could potentially give rise to clinically significant symptoms in later life. The issue raises …
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Identification of novel gastric stem cell markers and investigation of Intestinal Stem Cell Cre-mediated Recombination
… increasing our basic understanding of gastric tissues and studying mechanisms of cancer development. Gastric and intestinal tissues share a common developmental program. Thus, intestinal stem cell genetic drivers were investigated for putative expression in gastric stem cells, utilizing Cre/Lox …
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Tissue-encoded Design Principles of Host Defense
… and are a result of inappropriate activation of tissue-resident immunity. This inappropriate activation can be derived from any number of cell types, including immunoregulatory functions of non-immune cells such as epithelial cells. In this thesis, we investigated tissue metabolism and …
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Isoprenylation and NET formation in acute pancreatitis
… leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and geranylgeranyltransferase) as well as NET formation in regulating recruitment of neutrophils and tissue damage in severe AP. …
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Epidermis and Re-epithelialization in <i>Schmidtea mediterranea</i>
… its ability to close the wound is essential for tissue recovery. Planarian epidermis enables animal recovery and survival after virtually any body part amputation. Nevertheless, neither the epidermis nor the mechanisms endowing such a remarkable wound healing capacity is described in detail in …
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Damage-Induced Inflammation and Nociceptive Hypersensitivity In Drosophila Larvae
Mounting an effective response to tissue damage requires a concerted effort from a number of systems, including both the immune and nervous systems. Immune-responsive blood cells fight infection and clear debris from damaged tissues, and specialized pain receptors become hypersensitive to promote …
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A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice
… route) induced a cytokine storm, massive organ damage, and severe vascular leakage, leading to hemorrhage and rapid death of the animals at the peak of viremia. In contrast, very interestingly and uniquely, ip. infection with a low dose of D2Y98P (10^4 PFU) led to asymptomatic viral …
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Influence of Peripheral Immune-Derived EphA4 on Microglial Dynamics Following Traumatic Brain Injury
… peripheral immune cells that coordinate tissue damage and functional deficits. The activation of resident microglial has been associated with a change in their morphology from a branched-like ramified cell to an ameboid state. This activation is thought to initiate a pro-inflammatory …
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MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS
Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes …
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The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… matrix components resulting in massive local tissue damage. To better understand the mechanism in which venom induces local tissue damage, human embryonic kidney cells (HEKS) were grown on PEI then stimulated with 500μg/ml <em>Crotalus atrox</em> (CA) venom for 4 and 10 hours. Alamar Blue …
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Silicon processing for microfluidic neuroprobes
… of the probe must be minimized to limit brain tissue damage. This thesis describes the fabrication process of a novel microfluidic-based neuroprobe capable of obtaining neuromodulators with high spatial and temporal resolution with limited tissue damage. This is achieved through the use of …
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The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
… solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for transplantation in the UK has led to the increasing use of ‘less-than-ideal’ deceased organs that are less tolerant of ischaemia or have been exposed to greater …
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