Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Tissue Selectivity"”.
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Characterisation of oestrogenic properties of Isoflavones derived from Millettia griffoniana Baill.: - Molecular mode of action and tissue selectivity
… 17β-oestradiol on uterine hepatic and vena cava tissues of ovariectomised rats except for the proliferative response. However Griff C remained 100 to 1000 times less effective than oestradiol. These findings confirmed that some of the biological effects attributed to Millettia griffoniana are …
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Nitroxide Spin Labels as NMR Contrast Agents: Delivery, Metabolism and Relaxation
… to their nonparamagnetic state, lack of tissue selectivity, and relatively low relaxivity of nitroxides, were, in part, overcome by the use of liposomes as the delivery system.
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Investigations of the Tissue Mechanical Properties and Susceptibility to Histotripsy-Induced Tissue Ablation for Intra-Abdominal Organs
… acoustic cavitation to mechanically break down tissues [1-8]. Histotripsy is heavily dependent on the mechanical properties of the tissue, allowing it to mechanically ablate tissues of lower mechanical stiffness while preserving the stiffer critical structures [15]. However, the mechanical …
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Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
… fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios being 43 and 17 at one hour after injection for 1 and 2, respectively. The …
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I. A Structure-Based Approach Toward the Development of a Ligand-Receptor System With Unique Specificity. II. Synthesis and Evaluation of Hexahydrochrysene and Tetrahydrobenzofluorene Derivatives as Selective Estrogen Receptor Modulators
… estrogenic effects. Partial agonists, with a tissue selective agonist/antagonist profile, termed selective estrogen receptor modulators (SERMs), are better candidates for applications in the treatment of estrogen sensitive breast cancer and pathologies associated with postmenopausal …
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Clinical observations on yaws as studied on the west coast of Africa, 1922-1936
… shown to be hereditary or to affect true nervous tissues. • 7. Acquired immunity to the disease exists but is not certain. • 8. Apparent cure is simple. • 9. Sure and lasting cure is a long and expensive process. • 10. Inadequate treatment may precipitate the tertiary stage, especially of the bony …
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Molecular bases, pathogenic mechanisms and possible therapeutic approach in Leber's Hereditary Optic Neuropathy
… prevalence, the incomplete penetrance and the tissue selectivity. This maternally inherited disease is caused by mutations in mitochondrial encoded genes of NADH ubiquinone oxidoreductase (complex I) of the respiratory chain. The 90% of LHON cases are caused by one of the three common …
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… but their application for delivery to non-liver tissues is limited. Exploring alternatives to ionizable cationic lipids, such as ionizable polymers [e.g. amino-polyesters (APE)], is therefore paramount to help expand the therapeutic utility of mRNA in acute inflammatory diseases such as sepsis. …