Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Tissue Scaffolds"”.
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Fabrication of tissue scaffolds using projection micro-stereolithography
… fail to capture the complexity of in vivo tissue behavior. One of the most critical features of the in vivo liver is the extensive microvasculature which allows for the delivery of nutrients and metabolites without exposing hepatocytes to de-differentiating fluidic shear stresses. A new …
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Production of hard tissue scaffolds using three-dimensional printing method
Synthesised bone replacement scaffolds provide the possibility to individually tailor properties, overcome limited donor availability and improve osteointegration. The aim of bone tissue engineering is to provide solutions to these problems by making available high quality transplants that can be …
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Investigation into the dispensing-based fabrication process for tissue scaffolds
Tissue engineering is a multidisciplinary subject aimed at producing the immunologically tolerant ‘artificial’ tissues/organs to repair or replace damaged ones. In this field, tissue scaffold plays a key role to support cell growth and new tissue regeneration. For fabrication of tissue scaffolds …
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Design and fabrication of physiologic tissue scaffolds using projection-micro-stereolithography
… It is an ideal candidate, therefore, for making tissue scaffolds with sophisticated microscopic architecture. Nearly all multicellular biological tissues display a hierarchy of scale. In human tissues, this means that the mechanics and function of an organ are defined by structural organization …
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Bioresorbable Electrospun Tissue Scaffolds of Poly(ethylene glycol-b-lactide) Copolymers for Bone Tissue Engineering
… are FDA-approved for clinical use. Preliminary tissue culture studies have demonstrated that these poly(α-hydroxy esters) support bone tissue development both in vitro and in vivo, but biocompatibility issues still exist. Tissue scaffolds fabricated from these materials by current methods have …
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The Synthesis and Characterisation of Novel Low Molecular Weight Gelators and their Applications in Electrospinning to Develop Biocompatible Materials and Tissue Scaffolds
… of these materials as drug delivery systems and tissue scaffolds were carried out by our collaborators.
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Development of cell-laden hydrogels with high mechanical strength for tissue engineering applications
… remains a critical challenge for applications as tissue scaffolds. Particularly, scaffolds for load-bearing tissues such as cartilage and bone need to have great strength to keep their integrity after implantation. This thesis focused on the development of cell-laden hydrogels that have high …
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A scalable process for rapid and uniform assembly of repeated origami-like structures using elastic membranes
… application of this work is the assembly of tissue scaffolds for replacement of human tissues and organs. A folding process capable of creating complex 3D geometries in a highly parallel, highly uniform fashion would enable the production of tissue scaffolds or other flexible systems at a …
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Additive manufactured biodegradable and biocompatible polymeric nanocomposite scaffolds for bone tissue engineering applications
… biodegradable nanocomposite Polymeric Bone Tissue Scaffolds (PBTS). PBTSs are complex products, which have attracted significant attention in the literature in recent decades. In this study, a commercial and user-friendly FDM manufacturing technique was used to fabricate Polycaprolactone …
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Designing Scaffolds for Directed Cell Response in Tissue Engineering Scaffolds Fabricated by Vat Photopolymerization
… VP an attractive option for the fabrication of scaffolds for tissue engineering. However, there are few printable materials with low cytotoxicity that encourage cellular adhesion. In addition, these resins are not readily available and must be synthesized. A novel resin based on …
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2D and 3D periodic templates through holographic interference lithography : photonic and phononic crystals and biomimetic microlens arrays
… phononic crystals, drug delivery, microtrusses, tissue scaffolds, microfluidics and colloidal crystallization. A correlation between structure and photonic band gap properties was established by systematically exploring the 11 FCC space groups. This resulted in a technique to search for photonic …
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Electromagnetic stimulation of a composite scaffold for wound healing
… AT AUTHOR'S REQUEST.] Decellularized tissues have been investigated as natural sources for tissue scaffolds as synthetic mimicry of the natural extracellular matrix is quite difficult. In addition, gold nanomaterials have been studied for their ability to provide nanostructural cues …
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Tunability of Electrospun Scaffolds for Tissue Engineering
… a cheap and quick method of creating non-woven scaffolds for tissue regeneration and growth with the proper fiber diameter for cell adhesion. However, electrospun scaffolds lack large pores between fibers and result in a densely packed mesh in which cells can adhere only to the surface of the …
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Indirect Tissue Scaffold Fabrication via Additive Manufacturing and Biomimetic Mineralization
… manufacturing (AM) can be used to create tissue-specific three-dimensional scaffolds with controlled porosity and pore geometry (meso-structure). However, due to the relatively few biocompatible materials available for processing in AM machines, direct fabrication of tissue scaffolds is …
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Size-dependent mechanical properties of single polyurethane nanofibres
… are also an excellent candidate for engineered tissue scaffolds since the fabricated structure mimics that of an extracellular matrix. When cells are seeded onto a fabricated mesh, their behaviour strongly depends on the biomaterial's properties. Various studies have already confirmed the role …
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Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
… full structure and function to the native state. Tissue engineering holds promise to create cartilage grafts capable to withstand the stresses present in joints. More than 90% of articular cartilage tissue is composed of extracellular matrix and is located in the loading environment under low …
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Localized Excitation Fluorescence Imaging (LEFI)
A major limitation in tissue engineering is the lack of nondestructive methods to assess the development of tissue scaffolds undergoing preconditioning in bioreactors. Due to significant optical scattering in most scaffolding materials, current microscope-based imaging methods cannot "see" through …
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Structure-property-processing relationships between polymeric solutions and additive manufacturing for biomedical applications
… AM, such as personalized dosage pharmaceuticals, tissue scaffolds, and medical devices, require specific material properties such as biocompatibility and biodegradability, etc. Polymers possess many of these qualities and tuning molecular structure enables a functional material to successfully …
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Poly(N-Isopropylacrylamide)-based scaffolds for tissue engineering applications
… potential of poly(Nisopropylacrylamide)- based scaffolds in tissue engineering applications, specifically spinal injury and nucleus pulposus replacement. Poly(N-isopropylacrylamide), denoted PNIPAAm, is a synthetic polymer with hydrophilic properties at room temperature, but above 32C the chains …
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Controlling Cocontinuous Polymer Blends with Nanofillers Jammed at the Interface
… plastics, porous membranes for filtration and tissue scaffolds for drug delivery devices. As the cocontinuous morphology is in a non-equilibrium state, the thermodynamic instability causes the morphology to coarsen during post-mixing processing, which is a major drawback for applications. In …
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