Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Tissue Resident"”.
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Tissue-resident immunity in the human kidney
… Amongst these cells lies a network of tissue-resident immune cells with incompletely characterised roles in tissue homeostasis, repair, and defence. Furthermore, different regions of the kidney are affected by distinct immunologically relevant insults - ascending bacterial infection in …
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The role of tissue-resident immune cells in PanIN to PDAC progression
… to local suppression of anti-tumour immunity. Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been described. In this …
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
<p>Tissue-resident memory T-cells (T<sub>RM</sub>) provide frontline defense against viral diseases and can contribute to anti-tumor immunity; however, aside from the necessity of TGF-β, little is known regarding cues for T<sub>RM</sub> differentiation. Oxygen tension is an environmental cue that …
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Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organs
… a population of bona-fide self-renewing, tissue-resident B cells, represented mainly by innate-like CD5+ B-1 cells, across murine NLOs, including lung, liver, kidney and bladder. The size and phenotype of this tissue-resident B-cell subset was influenced by genetic background, age and the …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
… signals by examining MHV68 infection in tissue resident peritoneal macrophages, called large peritoneal macrophages (LPMs), during coinfection with a parasite, Heligmosomoides polygyrus (HP). We found that coinfection with HP increases the number of MHV68-infected LPMs during acute …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… acute cytokine storm, cytopenia, and local tissue damage. Current preclinical models of severe influenza, in small animal models and in vitro, fail to recapitulate the human immune response to severe viral infection accurately. Here, we bioengineered a human lung tissue model that represents …
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Systematic analysis of the molecular mechanisms of T cell entry into tissues
… of T cells establish residency in non-lymphoid tissues and function to provide local immune protection and tissue homeostasis. Classically, immunologists have inferred immune function from immune cells sampled from the blood and lymphoid organs, despite the challenged tissue representing the key …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… A growing body of evidence suggests that tissue-resident macrophages in a variety of different organs interact with the epithelium to promote tissue regeneration and repair. We previously demonstrated that in the absence of macrophages epithelial repair after irradiation injury is …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
… Lymphoid Cells (ILC2s) are recently discovered tissue resident immune cells, studied more commonly in barrier tissues like the lung and intestine. ILC2s are critical mediators of early type-2 immune responses and play a crucial role in the clearance of parasites, but also in the development of …
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… is secreted by various immune cells, including tissue-resident iNKT cells. In IBD, iNKT cells exhibit either pro-inflammatory or tolerogenic activities depending on the microbiota, raising questions about their role in CAC development. To investigate this, high-dimensional single-cell cytometry, …
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Immune Regulatory Role of Human CD141+ Dendritic Cells in Humanised Models of Alloimmunity
… anti-host effector cell reactivity and cutaneous tissue infiltration. Despite this, the presence of Tcell subsets and tissue homing markers has only recently been characterised in the peripheral blood of patients and has never been properly defined in Hu-PBMC models of GvHD. Engrafted human cells …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… CD39+CD8+T cells often co-express the tissue resident memory marker CD103 and display an exhausted tissue resident memory T cell phenotype that shows cytotoxicity against neoplastic cells. CD39 acts in concert with CD73 to generate adenosine and thereby promote immunosuppression in the …
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Sources of Pulmonary GM-CSF and Its Roles in Myeloid Cell Homeostasis
… environmental cue that defines the identity of tissue-resident macrophages. Utilizing newly developed transgenic Csf2-reporter mice, we aimed to profile GM-CSF expression in various barrier tissues, including the lung and skin. In the lung, we detected Csf2-reporter expression in immune cells …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
… host immune system is essential to maintaining tissue homeostasis and clearing pathogens. Tissue-resident macrophages (TRM) are innate immune cells that first appear at primitive hematopoiesis to facilitate fetal organ growth. After birth and depending on environmental cues, monocytes may …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… self-antigens and destroys body’s own cells and tissues. Chronic autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and the primary Sjögren’s syndrome (pSS) decrease life quality of patients and can lead to life threatening events such as lupus nephritis …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
… structures and regulation of immune responses by resident immune cells contribute to this balance. However, the contribution of tissue-resident non-immune cells within these barriers remains understudied. By employing cutting edge human and mouse models, I was able to maintain three-dimensional …
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
… while females prefer Th2 responses. As tissue-resident innate lymphoid cells (ILC) are novel immune cells that are the innate complement to T cells, understanding their role in aging and sex differences is imperative.</p> <p>Here, ILCs are characterized within various C57Bl6/J mice …
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Investigating the Reconstitution and Function of Peritoneal Cavity Macrophages after LPS-induced Peritonitis
The tissue-resident macrophages of the peritoneum are sentinel immune cells, in constant motion within the serous fluid of the abdomen. Like most tissue macrophages, the GATA6+ large peritoneal macrophages (LPMs) are responsible for the clearance and removal of pathogens that may break through the …
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Tissue-encoded Design Principles of Host Defense
… and are a result of inappropriate activation of tissue-resident immunity. This inappropriate activation can be derived from any number of cell types, including immunoregulatory functions of non-immune cells such as epithelial cells. In this thesis, we investigated tissue metabolism and …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… of the body. As such, it exerts homeostatic tissue functions, including digestion, sensing and absorption of nutrients, and excretion of waste products. In performing these roles, the intestine faces the unique challenge of remaining tolerant to harmless or beneficial diet- and microbederived …
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