Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"Tissue Plasminogen Activator"”.
-
Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
… to as fetal alcohol syndrome (FAS). Since tissue plasminogen activator (tPA) has been implicated in mediating excitotoxic neurodegeneration we subjected neonatal WT and tPA<sup>-/-</sup> to an acute ethanol paradigm that serves as a model of FAS. We observed persistent upregulation of tPA …
-
Synthesis and expression of the Erythrina trypsin/tissue plasminogen activator (tPA) inhibitor encoding-gene : genetic dissection to correlate the interaction of Erythrina and Soybean trypsin inhibitors with tPA
… to trypsin, it inhibits chymotrypsin and tissue plasminogen activator (tPA). ETI was previously sequenced and its crystal structure determined from which it could be seen that ETI has good homology to soybean trypsin inhibitor (STI). However, STI does not inhibit tPA. From the …
-
Perkutane koronare Intervention bei Stenosen und Verschlüssen in aortokoronaren Venenbypässen - Wertigkeit der zusätzlichen lokalen Thrombolyse im Vergleich zur alleinigen Ballondilatation mit Stent
… lokoregionalen Thrombolyse mit recombinant tissue plasminogen activator in der Therapie stenosierter und verschlossener aortokoronarer Venenbypässe. Dieser Untersuchung wurde eine systematische retrospektive Auswertung der Therapieverläufe und Koronarangiographiefilme von insgesamt 127 …
-
Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
… well understood. Outwith pregnancy, stimulated tissue plasminogen activator (t-PA) release, platelet activation, arterial stiffness and circulating endothelial progenitor cell (EPC) number are established indicators of vascular pathology and prognosis.
-
Cloning and characterization of the Pichia Pastoris PMR1 gene
… of prochymosin, human prourokinase, and human tissue plasminogen activator in Saccharomyces cerevisiae, was cloned from P. pastoris. The pmr 1 mutant in S. cerevisiae also displayed a slow growth phenotype when grown on low Ca<sup>2+</sup> medium. The putative P. pastoris PMR1 gene, encoding …
-
Analyzing Extracellular Vesicles as Potential Biomarkers of Stroke Using Polymer Microfluidic Devices
… 4.5 h from stroke onset afforded by recombi-nant tissue plasminogen activator treatment. Upon initiation of a stroke event, CD15+ neu-trophils and CD8+ T cells are recruited and activated in response to the inflammatory stroke event and can release into blood extracellular vesicles (EVs) …
-
Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre
… disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to assess the short-termoutcomes and safety of …
-
Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
… of several proteolytic components including, tissue plasminogen activator (tPA), plasminogen, procathepsin B and tenascin C. Targeting the Nterminus of AnxA2 with a competitive hexapeptide that prevents the binding of proteolytic components inhibited the AnxA2-mediated neovascular responses. …
-
Cardioprotective treatment strategies
… (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. ADC-1004 is an …
-
A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… were non-amyloid and resistant to ADAMTS13 and tissue plasminogen activator. Factors XIIa and XIa were captured in VWF fibers during aggregation, and could initiate fibrin formation on VWF. When whole blood was perfused over VWF fibers, platelets rolled, bound, and activated in a shear-dependent …
-
Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… At present, intravenous administration of tissue plasminogen activator (t-PA) is the only thrombolytic therapy approved by the FDA for the treatment of acute ischemic stroke. There are no other effective treatments available so far. The discovery of new drugs and new treatments for stroke …
-
Proteolytic mechanisms involved in the metastasis of human melanoma cells
… which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that …
-
The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… treatment options for ischemic stroke, with tissue plasminogen activator (tPA) being the only effective medication and a narrow administration window, which is also accompanied with the high incidence of ischemic stroke in HIV-1 infected individuals. Therefore, it is critical to explore an …
-
Bioenergetic and functional impacts of glucose, fructose and insulin in endothelial cells:: implications for cardiovascular disease in diabetes
… vessel tone (NO, endothelin-1) and fibrinolysis (tissue plasminogen activator, plasminogen activator inhibitor-1). These effects were not reversed after acute exposure to NG. Addition of fructose increased markers of metabolic activity, but reduced NO generation. The effect of insulin was complex, …
-
Targeting autophagy for improving stem cell function in brain repair
… following stroke. Aside from intravenous (i.v.) tissue plasminogen activator (tPA), there is no current cure or treatment for stroke. As a result, this study aims to target autophagy in neural stem cells to identify if stem cell functionality can be improved in in vivo models of ischaemic brain …
-
Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… fibrinolytic (ie blood clot dissolving) system, tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) were not affected by exposure to venous levels of shear stress (4 dynes/cm$\sp2$). However, at arterial shear stresses of 15 and 25 dynes/cm$\sp2$, the tPA …
-
Effects of combustion derived air pollution on vascular and fibrinolytic function in man
… myocardial ischemia and reduce acute endothelial tissue plasminogen activator release. In contrast, exposure to concentrated ambient particulates, low in combustion component, did not affect vascular function in either healthy volunteers or patients. I found little evidence that inhaled …
-
Investigation of the role of neuroserpin in neurite outgrowth and learning and memory
… in the nervous system and inhibits the protease tissue plasminogen activator (tPA). Neuroserpin has been shown to play a role in neurite outgrowth but con icting results have been reported. Neuroserpin has also been proposed to play a role in learning and memory but direct evidence for such a …
-
Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… rapid and complete reperfusion of the ischaemic tissue compared to recombinant tissue plasminogen activator (rtPA) alone. The advancements in imaging techniques, together with MT, have extended the therapeutic window of reperfusion therapy and have enhanced patient outcomes in ischaemic stroke. …
Page 1 of 2