Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Tissue Oxygen"”.
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Tissue Oxygen Imaging for Non-invasive Metastasis Detection
… evidence demonstrating significantly reduced oxygen in metastatic nodes, non-invasive oxygen imaging may improve metastasis detection while avoiding surgical morbidities.This thesis explores the application of a novel oxygen imaging method called Photoacoustic Lifetime Imaging (PALI) for early …
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Validation of tissue oxygen saturation determined by near-infrared spectroscopy in canine models of hypoxemia and hemorrhagic shock
… study was to evaluate the relationship between tissue oxygen saturation (StO2) and oxygen delivery index (DO2I). Oxygen delivery index is product of two factors arterial oxygen content (CaO2) and cardiac index (CI). In this study the relationship between DO2I and StO2 was evaluated by …
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Frequency-Domain Near-Infrared Spectroscopy in the Human Brain
Monitoring brain tissue oxygen supply, demand, delivery and consumption can be achieved by quantifying the absolute values of oxy- and deoxy-hemoglobin and how these quantities change over time during rest, functional activation, pathology, and disease. My dissertation describes the development, …
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Non-invasive objective assessment of diabetic foot ulcer healing with blood perfusion and tissue oxygenation
… examined the correlation between blood flow and tissue oxygenation in diabetic wounds. This thesis is a pioneering work that aims to develop a reliable diagnostic tool to address the tremendous need for coordinated and efficient DFU management via prediction of relative blood perfusion (τ) and …
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Brain energy metabolism: development and application of novel live methodologies
… with a specific focus on the substrates oxygen and glucose. It details the in vitro development and in vivo characterisation of microelectrochemical sensors for the detection of brain tissue oxygen, and the in vivo characterisation of oxygen and glucose electrodes in the hippocampus …
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Compression under pressure: physiological and methodological factors influencing the effect of compression garments on running economy
… the low-cost and light-weight MOXY device gave tissue oxygen saturation values at rest and during exercise that were physiologically credible and suitable for future research. Compression tights did affect ground contact time but not tissue oxygen saturation, cardiovascular or other kinematic …
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Multispectral Imaging of Skin Oxygenation
… technique for quantitative measurement of skin tissue oxygen saturation (StO2). Oxygen saturation is the percentage of oxygen carried in the blood over the total oxygen carrying capacity of blood. Skin StO2 is an important indicator of skin tissue clinical status. Measurement of skin tissue …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
Fluctuation in tissue oxygen tension results in systemic physiological, metabolic, and vascular changes in order to maintain cellular homeostasis. Using C57BL/6J mice exposed to normoxia, hypoxia or hyperoxia, we studied the systemic physiological and brain microvascular adaptive changes in …
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Autoregulation of blood flow during sympathetic nerve stimulation in the arteriolar network on cat sartorius muscle.
… a reduction in arterial pressure would reduce oxygen delivery and decrease tissue oxygen tension. We reasoned that the contribution of this mechanism to autoregulation of flow would be increased during sympathetic nerve stimulation because the latter causes arteriolar constriction and decreases …
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Tissue oxymetry using magnetic resonance spectroscopy
A noninvasive method for in vivo measurement of tissue oxygen concentration has been developed. Several techniques currently used suffer limitations that prevent their practical clinical use. Our method is to use the paramagnetism of molecular oxygen to build a method for noninvasive tissue …
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Optical Cerebral Blood Flow Monitoring of Mice to Men
… both employ near-infrared light to investigate tissue physiology millimeters to centimeters below the tissue surface. DOS is a static technique that analyzes multispectral tissue-scattered light intensity signals with a photon diffusion approach (Chapter 2) or a Modified Beer-Lambert law …
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Oxygen Polarography in the Awake Macaque: Bridging BOLD fMRI and Electrophysiology
<p>Blood oxygen level dependent (BOLD) fMRI is the predominant method for evaluating human brain activity. This technique identifies brain activity by measuring blood oxygen changes associated with neural activity. Although clearly related, the nature of the relationship between BOLD fMRI …
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The Assessment of Autonomic Function in Young Adults with an Elevated Risk of Metabolic Syndrome
… contraction (MVC), where HR, beat-by-by BP, and tissue oxygen saturation index (TSI) were recorded continuously. The change in mean arterial pressure vs the change in TSI were plotted to produce a slope quantifying the magnitude of the response. We found that individuals with an elevated risk of …
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Optical Imaging Of Tissue Physiology With Exogenous Contrast Agents
… emitting exogenous contrast agents in living tissue. The first set of experiments concurrently measured cerebral blood flow and bothintravascular- and extravascular-tissue oxygen concentration in a rat brain during functional activation; the new instrumentation needed to collect this …
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Novel Multifunctional Laser Diagnostics
… of around 3,000 functional scans, including tissue oxygen saturation and laser Doppler flowmetry, provides new insights into bio-technological issues. The challenges identified with biological characteristics include sampling zones and physiological features of the skin. Technological, …
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Oxygen diffusion limitations in pancreatic islet culture and immunoisolation
Data for oxygen consumption by rat islets of Langerhans in a batch microreactor were fitted using a numerical solution of the transient oxygen diffusion-reaction equation. Average best-fit values were 3.1 +/- 0.7 x 10-8 mol/cm3-s for the maximum oxygen consumption rate Vmax in aminoacid-free media …
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A novel approach to real-time monitoring of erythrocyte ATP release as a function of hypoxia
Background: Matching blood flow to tissue oxygen demand is essential for maintaining metabolic homeostasis and sustaining human life. Recent studies suggest that red blood cells (RBCs) play a role in local vasodilatory signaling by releasing ATP in response to hypoxia. RBC ATP release and overall …
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Development of small-molecule probes for photoacoustic imaging of hypoxia
Hypoxia occurs when tissue oxygen supply is restricted, inhibiting normal physiological processes. Because of the irregular vasculature of rapidly growing tumors, hypoxia is a hallmark of cancer and exists in 50-60% of solid tumors. Hypoxia-induced changes in gene expression lead to treatment …
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PHYSIOLOGICAL ADAPTATIONS TO HEAT ACCLIMATION; REPERCUSSIONS ON CYCLING PERFORMANCE
… were observed in electromyographic activity or tissue oxygen saturation either between environments or throughout acclimation. Chapter 7 revealed that heat acclimation led to enhancement of cycle time trial performance in hot, cool and hypoxic environments, where completing work matched training …
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Rheological aspects of sickle cell anemia and related hemoglobinopathies
… of certain hemoglobinopathies with respect to oxygen tension, the concept of optimum hematocrit was employed. The optimum hematocrit is defined as the hematocrit at which the erythrocyte flow rate is the greatest. It therefore represents the optimum oxygen carrying capacity of blood. Using a …
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